Nilgün ÜREN, Ulvi Reha FİDANCI, ALİ HAYDAR KIRMIZIGÜL, Vildan FİDANCI, MERT PEKCAN

Kronik böbrek yetmezlikli kedilerde homosistein düzeyleri

Bu çalışmada kronik böbrek yetmezliği (KBY) tanısı konulan dişi kedilerde serum homosistein düzeylerinin belirlenmesi ve bu değerin serum üre ve kreatinin düzeyleri ile ilişkisinin araştırılması amaçlanmıştır. Çalışmanın materyalini Ankara Üniversitesi Veteriner Fakültesi İç Hastalıkları Anabilim Dalı Kliniği’ne getirilen, klinik ve laboratuar olarak KBY teşhisi konulan 13 hasta ve 8 sağlıklı olmak üzere toplam 21 dişi kedi oluşturdu. Bu kedilerden alınan serum örneklerinden, üre, kreatinin ve homosistein düzeyleri belirlendi. Sağlıklı kedilerde üre, kreatinin ve homosistein değerleri sırasıyla 37.74±4.47 mg/dl, 1.46±0.14 mg/dl ve 13.03±2.81 μmol/L olarak ölçülürken, KBY’li kedilerde bu değerler sırasıyla 278.81±45.68 mg/dl, 6.14±0.80 mg/dl ve 41.68±9.97 μmol/L olarak ölçüldü. Sonuç olarak kedilerde KBY olgularında serum homosistein düzeyinin belirlenmesi hastalığın erken tanısına önemli bir katkı sağlayacağı, ayrıca konu ile ilgili herhangi bir çalışmaya rastlanılmaması nedeniyle bu konuda yapılacak diğer çalışmalara da ışık tutacağı kanısına varılmıştır.

Anahtar Kelimeler:

kedi, kronik seyir, böbrek hastalıkları, böbrek yetmezliği, homosistein, üre, kreatinin, kedi hastalıkları

Homocysteine levels in cats with chronic renal failure

In the present study serum homocysteine levels were determined in female cats diagnosed as chronic renal failure (CRF) and its correlation with serum urea and creatinin levels were investigated. The study was conducted on a total of 21 female cats (13 diseased and 8 healthy cats), admitted to the Department of Internal Medicine Clinics, School of Veterinary Medicine, University of Ankara, diagnosed as CRF upon clinical examination and laboratory results. Serum samples were retrieved from cats and urea, creatinin and homocysteine levels were determined. In healthy cats, urea, creatinin and homocysteine levels were 37.74±4.47 mg/dl, 1.46±0.14 mg/dl and 13.03±2.81 μmol/L, and in cats with CRF 278.81±45.68 mg/dl, 6.14±0.80 mg/dl and 41.68±9.97 μmol/L, respectively. In conclusion, determination of serum homocysteine levels in CRF cases occuring in cats could significantly contribute to the early diagnosis of the disease. Furthermore, to the best of our knowledge there is no such study conducted about this subject, it could also contribute for the further studies related to CRF.

Keywords:

cats, chronic course, kidney diseases, renal failure, homocysteine, urea, creatinine, cat diseases,

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