Ersen ERASLAN, Ömer TOPDAĞI, Ayhan TANYELİ, Fazile Nur EKİNCİ AKDEMİR, Mustafa Can GÜLER, Tuncer NACAR

Higenamin Ratlarda İskemi Reperfüzyonunun Neden Olduğu Oksidatif Böbrek Hasarını Azaltır

Bu araştırmanın amacı, higenaminin, iskemi reperfüzyonunun neden olduğu böbrek dokusu hasarı üzerine koruyucu etkilerini belirlemektir. Bu araştırmada 24 adet Sprague Dawley dişi sıçan üç gruba ayrıldı. Bu çalışmanın grupları aşağıdaki şekilde tasarlanmıştır; kontrol, iskemi reperfüzyon ve iskemi reperfüzyon + higenamin grupları. Deney sonunda elde edilen böbrek dokularındaki bazı oksidan, antioksidan ve inflamatuvar parametreler değerlendirildi. İskemi reperfüzyon grubu kontrol grubu ile kıyaslandığında, böbrek dokusundaki oksidan ve inflamatuvar parametrelerin arttığı fakat antioksidan parametrelerin azaldığı belirlendi. Tedavi grubu (iskemi reperfüzyon + higenamin) yalnızca iskemi reperfüzyon grubu ile kıyaslandığında antioksidan parametreler artarken, oksidan ve inflamatuvar parametreler azaldı. Bu sonuçlar, tek doz higenamin uygulamasının, iskemi reperfüzyon kaynaklı oksidatif böbrek hasarına karşı etkili olduğunu göstermiştir.

Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats

The aim of this research is to determine protective effects of higenamine on kidney tissue injury caused by ischemia reperfusion. In thisstudy, 24 Sprague Dawley female rats were divided into 3 groups. The groups were designed as follows; control, ischemia reperfusion, andischemia reperfusion + higenamine. Some oxidant, antioxidant and inflammatory parameters were evaluated in kidney tissues at the endof the experimental procedure. It was confirmed that the oxidant and inflammatory parameters of kidney tissue increased and antioxidantparameters decreased in ischemia reperfusion group compared to control group. Antioxidant parameters increased while oxidant andinflammatory parameters decreased in the ischemia reperfusion + higenamine group compared to ischemia reperfusion group. These resultshave demonstrated that higenamine administration as single dose is effective against oxidative kidney damage originating from ischemiareperfusion.

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