Generalized amyloidosis in a partridge (Alectoris chukar)
Bu çalışmada bir keklikte generalize amiloidozis olgusu tanımlandı. Çalışmanın materyalini Ankara Üniversitesi Veteriner Fakültesi Patoloji Anabilim Dalı’na nekropsi amacıyla getirilen 1 yaşlı, erkek, kınalı keklik (Alectoris chukar) oluşturdu. Nekropside karaciğer, dalak ve böbrekler oldukça şişkindi. Solgun renkte olan bu organların kolayca parçalandığı dikkati çekti. Histopatolojik incelemede; dalakta (kapsülada, beyaz pulpanın ince retiküler ağı boyunca, beyaz pulpa ve trabeküllerdeki damar duvarlarında); karaciğerde (disse aralıklarında, ve damar duvarlarında); böbreklerde (tubulusların bazal membranında ve damar duvarlarında); duodenum ve jejenumda (lamina propria’da, damar duvarlarında, tunika muskularis’te); kaslı ve bezli midede (lamina propria ve damar duvarlarında); pankreasta (damar duvarlarında); kalpte (miyofibrillerde); akciğerlerde (parabronşlarda ve damar duvarlarında); testislerde (tubulus bazal membranında ve damar duvarında) homojen, amorf pembe renkte birikimler gözlendi. Yapılan Congo-red özel boyasıyla bu birikimlerin kırmızımsı portakal renginde boyandığı, polarize ışık mikroskobu altında ise yeşil yansıma verdiği gözlendi. Yapılan immunohistokimyasal incelemede amiloid maddesi amiloid A(AA) proteinine karşı pozitif reaksiyon verdi. Bu veriler ışığında anılan birikimlerin kanatlı hayvanlar arasında özellikle su kuşlarında rastlanan, ancak diğer kanatlılarda nadir görülen amiloid birikimi (AA amiloid) olduğu saptandı.
Bir keklikte (kınalı keklik) generalize amiloidozis
This study describes a case of generalised amyloidosis in a rock partridge (Alectoris chukar). The case material was a 1 year-old male rock partridge submitted to the Department of Pathology, Faculty of Veterinary Medicine, University of Ankara for necropsy. In necropsy, the liver, spleen and kidneys were swollen, pale and fragil. Histopathologic examinations revealed pinkish amorph accumulation in spleen (on capsule, along reticular of white pulp, in the wall of blood vessel, white pulp, and trabeculae), liver (in the dysse spaces and on blood vessels’ walls), kidneys (on tubule basal membranes and blood vessels’ walls), proventriculus, gizzard (on lamina propria and blood vessels’ walls), small intestines (on lamina propria, tunica muscularis, blood vessels’ walls), pancreas (on blood vessels’ walls), heart (on blood vessels’ walls), lungs (on bronches and blood vessels’ walls) and testes (on basal membranes of tubulus and blood vessels’ walls). After staining Congo red, accumulations appeared in orange and in green under polarised light microscope. Immunohistochemically, amyloid substance stained positively against amyloid A protein. These accumulations were considered as amyloidosis, which is rare in exotic birds, but common in waterfowls..
___
- 1. Sato A, Koga T, Inoue M, Goto, N: Pathological observations of amyloidosis in swans and other Anatidae. Nippon Juigaku Zasshi, 43, 509-519, 1981.
- 2. Tanaka S, Dan C, Kawano H, Omoto M, Ishihara T : Pathological study on amyloidosis in Cygnus olor (Mute swan) and other waterfowl. Med Mol Morphol, 41, 99-108, 2008.
- 3. Zschlesche W, Jakob W: Pathology of animal amyloidosis. Pharmacol Ther, 41, 49-83, 1989.
- 4. Dren CN, Nemeth I, Sari I, Ratz F, Glavits R, Somogyi P: Isolation of a reticuloendotheliosis-like virus from naturally occurring lymphoreticular tumours of domestic goose. Avian Pathol, 17, 259-277, 1988.
- 5. Rigdon Rh, Mack J: Amyloidosis: Age of occurrence and rate of progression: Experimental study in the white Pekin duck. J Am Geriatr Soc, 17, 514-521, 1969.
- 6. Zschiesche W, Linke RP: Immunohistochemical characterization of spontaneous amyloidosis in captive birds as AA-type using monoclonal and polyclonal anti-AA antibodies against mammalian amyloid. Acta Histochem, 86, 45-50, 1989.
- 7. Presnell J, Schreibman MP: Animal Tissue Techniques. 5th ed. pp. 269-271. The Johns Hopkins University Press Ltd, London, 1997.
- 8. Nakamura K, Tanaka H, Kodama V, Kubo M, Shlbahara T: Systemic amyloidosis in laying japanese quail. Avian Dis, 42, 209-214, 1998.
- 9. Landman WJM, Gruys E, Dwars RM: A syndrome associated with growth depression and amyloid arthropathy in layers: A preliminary report. Avian Pathol, 23, 461-470, 1994.
- 10. Peperkamp NHMT, Landman WJM, Tooten PCJ, Ultee A, Voorhout WF, Gruys E: Light microscopic, immunohistochemical, and electron microscopic features of amyloid arthropathy In chickens. Vet Pathol, 34, 271-278, 1997.
- 11. Terim Kapakin KA, Kutsal O: Tavuklarda deneysel amiloid artropatinin ışık mikroskobik ve elektron mikroskobik incelenmesi. Ankara Univ Vet Fak Derg, 55, 37-43, 2008.
- 12. Nelwold TA, Tooten PC: Purification and characterization of hamster serum amyloid A protein (SAA) by cholesteryl hemisucicnate affinity chromatography. Scand J Immunol, 31, 389-396, 1990.
- 13. Glenner GG : Amyloid deposits and amyloidosis. The ßfibrilloses. N Engl J Med, 302, 1283-1292, 1980.
- 14. McMartin DA, Damassa AJ, Mckeen WD, Read D, Daft B, Lam KM: Experimental reproduction of Mycoplasma gallisepticum disease in Chukar Partridges (Alectoris graeca). Avian Dis, 40, 408-416, 1996.
- 15. Shivaprasad HL, Meteyer CU, Jeffrey JS: Amyloidosis in Turkeys. Proceedings of the 34. Annual Meeting of the American Association of Veterinary Laboratory Diagnosticians (p. 57). San Diego, California, 1991.
- 16. Ciftci A, Diker KS: The role of Enterococcal virulence factors on experimental amyloid arthropathy in chickens. Kafkas Univ Vet Fak Derg, 15 (6): 903-908, 2009.
- 17. Stepanets V, Vernerova Z, Vilhelmova M, Geryk J, Hejnar J, Svoboda J: Amyloid A amyloidosis in non-infected and avian leukosis virus-C persistently infected inbred ducks. Avian Pathol, 30, 33-42, 2001.