SAVAŞ YILDIZ, KUTLAY GÜRBULAK

Erkeklerde immunolojik infertiliteye genel bir bakış

Dölveriminin aksaması olarak tanımlanan infertilite, hayvan ıslahı ve yetiştiriciliğinde amaçlanan ekonomik verimi doğrudan etkilemesi nedeniyle, öteden beri bu sektörün en önemli sorunlarından birisi olmuştur. Bakım ve beslemeye, genital organların doğmasal veya edinsel bozukluklarına, enfeksiyöz faktörlere ve yaş durumuna bağlı olarak ortaya çıkabilen infertilite olgularının elimine edilmesine yönelik araştırmalar hala güncelliğini korumaktadır. Son zamanlarda bu etkenlerin dışında sebebi bilinmeyen ya da açıklanamayan infertilite olguları, immünolojik infertiliteye dikkati çekmektedir. İmmünolojik infertilite, hem erkeklerde infertiliteye neden olan asıl etkenin önceden tespitine gereksinim duyulmasına, hem de buna bağlı olarak tedavide geç kalınması nedeniyle diğer infertilite olgularına göre daha fazla verim kayıplarına neden olabilmektedir. Sunulan derlemede, erkeklerde ortaya çıkan immünolojik infertilite ve teşhis metotları hakkında genel olarak bilgi verilmiştir.

Anahtar Kelimeler:

erkek hayvanlar, antikor, teşhis, tanı teknikleri, immünoloji, kısırlık, çiftlik hayvanları, spermatozoa

Immunological infertilty in males

Fertility disorders, so-called as infertility, have been one of the main problems directly affecting economical benefit aimed at genetic improvement and animal breeding programmes in this sector. The studies to eliminate infertility cases due likely to arise from improper management and feeding, congenital or acquired disorders in genital organs, infectious factors or age status still remain quite popular. Other than the aetiological factors given, infertility cases with unknown origin attract considerable attention recently. Among these, immunological infertility as compared to other infertility cases in males may require both identification of the actual factor causing infertility beforehand and thus lead to more losses in productivity related to late treatment. Therefore In the present review, an attempt has been made to give some information on immunological infertility in males and diagnostic methods.

Keywords:

male animals, antibodies, diagnosis, diagnostic techniques, immunology, infertility, livestock, spermatozoa,

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1 Mazumdar S, Levine AS: Antisperm antibodies: Etiology, pathogenesis, diagnosis, and treatment. Fertil Steril, 70(5): 799-810,1998.
2 McLachlan RI: Basis, diagnosis and treatment immunological infertility in men. J Reprod Immunol, 57(1-2): 35-45,2002.
3 Shun Li T: Sperm immunology, infertility, and fertility control. Obstet Gynecol, 44(4): 607-623, 1974.
4 Peters AJ, Coulam CB: Sperm antibodies. Am J Reprod Immumol, 27: 156-162, 1992.
5 Minbay A: Reprodüktif İmmünoloji. In, Arda M, Minbay A, Aydın N, Akay Ö, İzgür M, Diker KS (Eds): İmmünoloji. Medisan, Ankara. P: 229-238, 1994.
6 Lombardo F, Gandini L, Lenzi A, Dondero F: Antisperm immunity in assisted reproduction. / Reprod Immunol, 62(1- 2): 101-109,2004.
7 Iammarrone E, Balet R, Lower AM, Gillot C, Grudzinskas JG: Male infertility. Best Practice&Research Clinical Obstetrics&Gynaecology,17(2): 211-229, 2003.
8 Matt K, Reimand U, Kadastik K, Uibo R: Immunological aspects of infertility. IntJGynaecol Obst, 70(2):B316,2000.
9 Alexander NJ: Reproductive immunology: relevance to infertility practice. Arch Immun Therap Exper, 38:23-29, 1990.
10 Kim CA, Parrish JJ, Momont HW, Lunn DP: Effects of experimentally generated bull antisperm antibodies on in vitro fertilization. Biol Reprod, 60(6): 1285-91, 1999.
11 Arda M: Immunogolubinler. In, Arda M, Minbay A, Aydın N, Akay Ö, îzgür M, Diker KS (Eds): İmmünoloji. Medisan, Ankara. P:47-52, 1994.
12 Oliveiro FG, Goncalves, SP, Andrade M, Abdelmassih R, Oliveira RM: Immunulogical abnormailites and infertility. Fertil Steril, 82(2): 320-321,2004.
13 Haas GGJR, Beer A: Immunologic influences on reproductive biology: sperm gametogenesis and maturation in the male and female genital tracts. Fertil Steril, 46(5): 753- 765,1986.
14 Marshburn PB, Kutteh HW: The role of antisperm antibodies in infertility. Fertil Steril, 61(5): 799-811, 1994.
15 El-Demiry MIM, Hargreave TB, Busuttil A, James K, Ritchie AWS, Chisholm GD: Lymphocyte subpopulation in the male genital tract. Br J Urol, 57: 769-74, 1985.
16 Anderson DJ, Hill JA: Cell-mediated immunity in infertility. Am J Reprod Immunol Microbiol, 17: 22-30, 1988.
17 Naz RKI: Molecular and immunological characteristics of sperm antigens involved in egg binding.j Reprod Immunol, 53(1-2): 13-23,2002.
18 Alexander NJ, Anderson DJ: Immunology of semen. Fertil Steril, 47(2): 192-205, 1987.
19 Kerr EL, Paterson M, Aitken RJ: Molecular basis of sperm- egg interaction and the prospects for immunucontraception. J Reprod Immunol, 40(2): 103-118, 1998.
20 Llanos M, Morales P: Interaction of human spermatozoa with the zona pellucida of oocyt. development of the acrosome reaction. Front Biol, 1: 146-160, 1996.
21 Bronson R, Cooper G, Rosenfeld D: Sperm antibodies: their role in infertility. Fertil Steril, 42(2): 171-183, 1984.
22 Kochetkov AA, Abilov AI, Oyvadis RN: Antisperm antibodies in male and embriyonic mortality. Seventh International Symposium on Immunology of Reproduction. Am J Reprod Immunol Microbiol, 16(2): 92, 1988.
23 Cunningham DS, Fulgham DL, Rayl DL, Hansen KA, Alexander NJ: Antisperm antibodies to sperm surface antigens in women with genital tract infection. Am J Obstet Gynecol, 164:791-6,1991.
24 Aydın N: İmmunostimulasyon ve immunostimulantlar. In, Arda M, Minbay A, Aydın N, Akay Ö, İzgür M, Diker KS (Eds): İmmünoloji. Medisan, Ankara. P:291-294, 1994.
25 Mulcahy G, Quinn PJ: A new of immunomodulators and their application in veterinary medicine.j Vet Pharmacol Therap, 9: 119-139,1986.
26 Gürbulak K: İmmunostimulant etkili levamizol'ün sığır mastitis, metritis ve fötal ölüm üzerine etkisi. Doktora Tezi. İstanbul Üniv Sağlık Bilimleri Enst İstanbul, 2003.