Hiperkolesterolemi oluşturulmuş tavşanlarda kefirin total kolesterol, trigliserit, HDL-kolesterol, LDL-kolesterol ve lipit peroksidasyonu üzerine etkisi

Hiperkolesterolemik bireylerin damarlarında oksidatif stresin arttığı bunun yanı sıra LDL (düşük dansiteli lipoprotein) oksidasyonunun ateroskleroz gelişiminde önemli bir basamak olduğu bilinmektedir. Bu çalışmada 2 ay süre ile diyetlerine kolesterol (%l,w/w) ilave edilen tavşanların ağırlıkları oranında (30 ml/kg/gün) kefir tüketmesi durumunda kan lipit düzeyleri ve oksidasyon durumu incelendi. Bu amaçla, 56 günlük yedirme periyodu sonunda serum total kolesterol, trigliserit, HDL-kolesterol, LDL-kolesterol ve malondialdehit (MDA) düzeyleri ölçüldü. Kefir, kontrol grubuna kıyasla serum lipid ve lipid peroksitlerindeki artışı önemli düzeyde engelledi. Sonuç olarak, kefirin hipokolesterolemik etkisinde antilipidemik ve antioksidan özelliklerinin rol oynadığı görüşüne varıldı.

Anahtar Kelimeler:

hayvan modelleri, tavşan, triyosilgliserol, oksitlenme, düşük yoğunluklu lipoprotein, lipit, lipit peroksidasyonu, kefir, hiperkolestrolemi, yüksek yoğunluklu lipoprotein, kalp hastalıkları, kalp, diyet, kolesterol, damar tıkanması

The effect of kefir on the total cholesterol, trigliceride, HDL- cholesterol, LDL- cholesterol and lipid peroxidation levels following hypercholesterolemia in rabbits

It is known that oxidative stress increases in the arters of hypercholesterolemic individuals and oxidation of LDL is considered to be an important agent in the development of atherosclerosis. The anti-hipercholesterolemic and anti-lipooxidative effect of kefir (30 ml/kg./body weight/day) on the rabbits fed with a cholesterol diet (1%, w/w feed) were investigated. After a 56 days of feeding, lipid and lipid peroxide levels in serum were determined. The total cholesterol, trigliseride, HDL-cholesterol and LDL-cholesterol, and malondialdehyde levels of serum samples were separatelly analysed. The supplamentation of kefir to diet caused significant supression in serum lipids and lipid peroxide. In conclusion, anti-hypercholesterolemic effect of kefir may be due to its antioxidative and antilipidemic effects.

Keywords:

animal models, rabbits, triacylglycerols, oxidation, low density lipoprotein, lipids, lipid peroxidation, kefir, hypercholesterolaemia, high density lipoprotein, heart diseases, heart, diet, cholesterol, atherosclerosis,

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