MAHİR KAYA, ZEYNEP PEKCAN, YUSUF ŞEN, DEVA BAŞAK BOZTOK ÖZGERMEN, OYTUN OKAN ŞENEL, ALİ BUMİN

Effects of Short-Acting Anaesthetics on Haemodynamic Function as Determined by Doppler Ultrasonography in Rabbits

Bu çalışma, kısa etkili anesteziklerin Doppler ultrasonografi ile saptanan hemodinamik fonksiyonlara etkilerini belirlemek amacıyla yürütüldü. Anestezi öncesi Yeni Zelanda tavşanlarının (n=24) sağ arteria carotis communis (CCA), aorta abdominalis (AA) ve sağ böbreğinden Doppler parametreleri [en yüksek sistolik kan akım hızı (psBFV), diyastol sonu kan akım hızı (edBFV), en düşük diyastolik kan akım hızı (mdBFV) ve rezistif indeks (RI)] elde edildi. Hayvanlar propofol (Grup P), %2.5 tiyopental sodyum (Grup T) ve ksilazin/ketamin HCl (Grup XK) ile anestezi altına alınarak, üç grup oluşturuldu. Anestezi sırasında aynı ölçümler tekrarlandı. Bazal değerler ile karşılaştırıldığında CCA’dan elde edilen psBFV Grup P’de yükseldi ve Grup T ve XK’daki değişim önemsizdi. Grup T ve XK’da AA’dan ölçülen psBFV bazal değerler ile kıyaslandığında azaldı. Sağ böbrekte, Grup P’nin psBFV ve Grup T’nin edBFV değerleri artarken, Grup T ve XK’da RI değeri azaldı. Sonuç olarak, propofol anestezisi bazal parametreler ile karşılaştırıldığında, CCA’deki RI, intrarenal RI ve AA’daki kan akımı hızlarını önemli ölçüde değiştirmediği tespit edildi. Veriler propofol anestezisinin tavşanlarda Doppler parametrelerini minimal düzeyde etkilediğini göstermektedir.

Anahtar Kelimeler:

anestetikler, ksilazin, hemodinamik, kan akışı, atardamarlar, aorta, ultrasonografi, tiyopental, tavşan, propofol, böbrekler, ketamin

Kısa-Etkili Anesteziklerin Tavşanlarda Hemodinamik Fonksiyonlara Etkilerinin Doppler Ultrasonografi ile Değerlendirilmesi

This study was carried out to determine the effects of short-acting anaesthetics on haemodynamic function determined by Doppler ultrasonography. Prior to anaesthesia, Doppler parameters [peak systolic blood flow velocity (psBFV), end-diastolic blood flow velocity (edBFV), minimum diastolic blood flow velocity (mdBFV) and resistive index (RI)] were obtained from the right common carotid artery (CCA), abdominal aorta (AA) and right kidney in New Zealand rabbits (n=24). Animals were then divided into 3 groups to be anaesthetized with propofol (Group P), 2.5% thiopental sodium (Group T) and xylazine/ketamine HCl (Group XK). During anaesthesia the same Doppler measurements were made. Compared with baseline values, psBFV obtained from CCA increased in Group P (P<0.02) and insignificantly changed in Groups T and XK. psBFV measured from AA in Groups T and XK decreased as compared with baseline values. In the right kidney, psBFV in Group P and edBFV in Group T increased, whereas RI value in Groups T and XK decreased. In conclusion, comparing baseline values, propofol anaesthesia did not significantly alter RI measured from CCA and kidney and blood flow velocities measured from AA. The data suggest that propofol anaesthesia in rabbits results in minimal changes in Doppler parameters.

Keywords:

anaesthetics, xylazine, haemodynamics, blood flow, arteries, aorta, ultrasonography, thiopental, rabbits, propofol, kidneys, ketamine,

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Szatmari V, Sotonyi P, Vörös K: Normal duplex Doppler waveforms of the major abdominal blood vessels in dogs. A review. Vet Radiol Ultrasound, 42, 93-107, 2001.
Riesen S, Schimd V, Gaschen L, Busato A, Lang J: Doppler measurement of splanchnic blood flow during digestion in unsedated normal dogs. Vet Radiol Ultrasound, 43, 554-560, 2002.
Novellas R, Gopegui RR, Espada Y: Effects of sedation with midazolam and butorphanol on resistive and pulsatility indices in healthy dogs. Vet Radiol Ultrasound, 48, 276-280, 2007.
Astrand H, Sandgren T, Ahlgren AR, Lanne T: Non-invasive ultra-sound measurements of aortic intima-media thickness: implications for in vivo study of aortic wall stress. J Vascular Surg, 37, 1270-1276, 2003.
Drelich-Zbroja A, Jargiello T, Szymanska A, Krzyzanowski W, El-Furah M, Szczerbo-Trojanowska M: The diagnostic value of levovist in Doppler imaging of visceral arteries in patients with abdominal angina before and after angioplasty. Eur J Ultrasound, 16, 225-235, 2003.
Lee H, Chang D, Lee Y, Eom K, Choi H, Seo K, Choi M, Yoon J: Use of color Doppler imaging for determining the resistive index of the medial long posterior ciliary artery in clinically normal conscious dogs. Am J Vet Res, 63, 211-214, 2002.
Hofmeister EH, Williams CO, Braun C, Moore PA: Propofol versus thiopental: Effects on peri-induction intraocular pressures in normal dogs. Vet Anaesth Analg, 35, 275-281, 2008.
Hall LW, Clarke KM, Trim CM: General pharmacology of the injectable agents used in anaesthesia. In, Veterinary Anaesthesia. 10rd ed, pp. 113-129. WB Saunders Co. 2001
VanNatta ME, Rex DK: Propofol alone titrated to deep sedation versus propofol in combination with opioids and/or benzodiazepines and titrated to mo derate sedation for colonoscopy. Am J Gastroenterol, 101: 2209-2217, 2006.
Difilippo SM, Norberg PJ, Suson UD, Savino AM, Reim DA: A comparison of xylazine and medetomidine in an anaesthetic combination in New Zealand white rabbits. Contemp Top Lab Anim Sci, 43, 32-34, 2004.
Muir WW, Skarda RT, Milne DW: Evaluation of xylazine and ketamine hydrochloride anesthesia in horses. Am J Vet Res, 38, 195-201, 1977.
Rivers BJ, Walter PA, Letourneau JG, Finlay DE, Ritenour ER, King VL, O’Brien TD, Polzin DJ: Duplex Doppler estimation of resistive index in arcuate arteries of sedated, normal female dogs: Implications for use in the diagnosis of renal failure. J Am Anim Hosp Assoc, 33, 69-76, 1997.
Lee SW, Hankes GH, Purohit RC, Bartels JE, Cartee RE, Pablo L, Conti JC: Comparative study of ultrasonography and arteriography of the carotid artery of xylazine-sedated and halothane-anesthetized goats. Am J Vet Res, 51, 109-113, 1990.
Rivers BJ, Walter PA, O’Brien TD, Polzin DJ: Duplex Doppler estimation of Pourcelot resistive index in arcuate arteries of sedated normal cats. J Vet Intern Med, 10, 28-33, 1996.
Mitchell SK, Toal RL, Daniel GB, Rohrbach BW: Evaluation of renal hemodynamics in awake and isofluorane-anesthetized cats with pulsedwave Doppler and quantitative renal scintigraphy. Vet Radiol Ultrasound, 39, 451-458, 1998.
Carroll B: Doppler sonographic imaging of the vascular system. Report of the ultrasonography task force. JAMA, 265, 2382-2387, 1991.
Doursout MF, Joseph PM, Liang YY, Hartley CJ, Chelly JE: Role of propofol and its solvent, intralipid, in nitric oxide-induced peripheral vasodilatation in dogs. Br J Anaesth, 89, 492-498, 2002.
Lin GS, Spratt RS: Hemodynamic imaging with pulsatility index and resistive index color Doppler US. Radiology, 204, 870-873, 1997.
Bilotta F, Fiorani L, La RI, Spinelli F, Rosa G: Cardiovascular effects of intravenous propofol administered at two infusion rates: A transthoracic echocardiographic study. Anaesthesia, 56, 266-71, 2001.
Rouby JJ, Andreev A, Leger P, Arthaud M, Landault C, Vicaut E, Maistre G, Eurin J, Gandjbackh I, Viars P: Peripheral vascular effects of thiopental and propofol in humans with artificial hearts. Anesthesiol, 75, 32-42, 1991.
Nakamura K, Hatano Y, Hirakata H, Nishiwada M, Toda H, Mori K: Direct vasoconstrictor and vasodilator effects of propofol in isolated dog arteries. Br J Anaesth, 68, 193-197, 1992.
Baumgartner C, Bollerhey M, Henke J, Wagner S, Ungerer M, Erhardt W: Effects of propofol on ultrasonic indicators of haemodynamic function in rabbits. Vet Anaesth Analg, 35, 100-112, 2008.
Roth DM, Swaney JS, Dalton ND, Gilpin EA, Ross J: Impact of anesthesia on cardiac function during echocardiography in mice. Am J Physiol Heart Circ Physiol, 82, 2134-2140, 2002.
Gao XM, Kiriazis H, Moore XL, Feng XH, Sheppard K, Dart A, Du XJ: Regression of pressure overload-induced left ventricular hypertrophy in mice. Am J Physiol Heart Circ Physiol, 288, 2702-2707, 2005.
Xu Q, Ming Z, Dart AM, Du XJ. Optimizing dosage of ketamine and xylazine in murine echocardiography. Clin Exp Pharmacol Physiol, 34, 499-507, 2007.
Sandford TD, Colby ED: Effects of xylazine and ketamine on blood pressure, heart rate, and respiratory rate in rabbits. Lab Anim Sci, 30, 519-524, 1980.
Baumgartner C, Bollerhey M, Ebner J, Laacke-Singer L, Schuster T, Erhardt W: Effects of ketamine-xylazine intravenous bolus injection on cardiovascular function in rabbits. Can J Vet Res, 74, 200-208, 2010.
Petersen LJ, Petersen JR, Talleruphuus U, Ladefoged SD, Mehlsen J, Jensen HA: The pulsatility index and the resistive index in renal arteries. Associations with long-term progression in chronic renal failure. Nephrol Dial Transplant, 12, 1376-1380, 1997.
Kaya M, Bumin A, Şen Y, Alkan Z: Comparison of excretory urography, ultrasonography-guided percutaneous antegrade pyelography, and renal Doppler ultrasonography in rabbits with unilateral partial ureteral obstruction: An experimental study. Kafkas Univ Vet Fak Derg, 16, 735-741, 2010.
Kırmızıgül AH, Kaya M, Bumin A, Kalınbacak A: Evaluation of resistive index parameter in peritoneal dialysis in dogs with experimental bilateral proximal ureteral obstruction. Kafkas Univ Vet Fak Derg, 13, 33-38, 2007.
Platt JF, Rubin JM, Ellis JH: Distinction between obstructive and nonobstructive pyelocaliectasis with duplex Doppler sonography. Am J Roentgenol, 153, 997-1000, 1989.
Mostbeck GH, Gössinger HD, Mallek R, Siostrzonek P, Schneider B, Tscholakoff D: Effect of heart rate on Doppler measurements of resistive index in renal arteries. Radiology, 175, 511-513, 1990.
Mather LE, Selby DG, Runciman WB: Effects of propofol and of thiopentone anaesthesia on the regional kinetics of pethidine in the sheep. Br J Anaesth, 65, 365-372, 1990.
Runciman WB, Mather LE, Selby DG: Cardiovascular effects of propofol and of thiopentone anaesthesia in the sheep. Br J Anaesth, 65, 353-359, 1990.
Selby DG, Mather LE, Runciman WB: Effects of propofol and of thiopentone anaesthesia on the renal clearance of cefoxitin in the sheep. Br J Anaesth, 65, 360-364, 1990.