Y. Nihal GÜL SATAR, İ. Taci CANGÜL, Ayşe TOPAL, Ayberk OKTAY, Kivanc INAN, M. Barış AKGÜL

Effects of Ankaferd Blood Stopper (ABS) and topical tripeptide copper complex (TCC) on wound healing in rats: An experimental study

Bu çalışmada, Ankaferd Blood Stopper (ABS) ve tripeptid bakır kompleksinin (TCC) ratlarda yara iyileşmesi üzerine etkilerinin araştırılması amaçlanmıştır. Sprague-Dawley ırkı, dişi, 24 adet rat, rastgele şekilde 1) ABS, 2) TCC, ve 3) Kontrol olmak üzere 3 gruba ayrıldı. Skapulanın kaudal sınırına yakın sahada bilateral deneysel yaralar oluşturuldu. Her bir yara günlük olarak grubuna göre ABS solüsyon emdirilmiş sponjlar, topikal TCC jel ya da serum fizyolojik ile tedavi edildi. İyileşmemiş yara alanı 0, 7, 14 ve 21. günlerde ölçüldü ve histopatolojik analiz için biyopsi örnekleri alındı (0. gün haricinde). İlk gözlenebilir granulasyon dokusu oluşumu ortalama zamanı açısından ABS, TCC ve kontrol grupları arasında anlamlı istatistiki fark yoktu (sırasıyla 5.8, 5.5 ve 6.7 gün) (P>0.05). Açık yara sahasının deri düzeyine kadar granulasyon dokusu ile dolma süresi, kontrol grubunda ABS ve TCC grubundan anlamlı şekilde daha düşüktü (sırasıyla 18, 9 ve 11 gün). ABS ve TCC ile tedavi edilen yaraların 7, 14 ve 21. günlerde yapılan ölçümlerinde ortalama iyileşmemiş yara sahasının kontrol grubuna kıyasla anlamlı şekilde daha küçük ve ortalama total yara iyileşme yüzdesinin kontrol grubuna göre anlamlı şekilde daha büyük olduğu gözlendi (P

Ankaferd Blood Stopper (ABS) ve topikal tripeptid bakır kompleksinin (TCC) ratlarda yara iyileşmesi üzerine etkisi: Deneysel çalışma

We investigated the effects of Ankaferd Blood Stopper (ABS) and tripeptide copper complex (TCC) on wound healing in rats. A total of 24 outbred, male, Sprague-Dawley rats were randomly divided into (1) ABS, (2) TCC, and (3) control groups. Bilateral experimental wounds were created near the caudal border of the scapula. Each wound in the respective treatment group was treated daily with sponges soaked in ABS solution, topical TCC gel, or saline. On days 0, 7, 14 and 21, unhealed wound area was measured and biopsy samples were taken for histopathological analysis (except day 0). Median time for the first observable granulation tissue was not significantly different in the ABS, TCC, and control groups (5.8, 5.5, and 6.7 days, respectively) (P>0.05). Filling of the open wound with granulation tissue to skin level was significantly slower in the control group than in the ABS and TCC groups (18, 9, and 11 days, respectively). The mean unhealed wound area was significantly smaller and the mean percentage of total wound healing was significantly higher in the ABS- and TCC-treated wounds than in the control wounds on day 7, 14, and 21 (P<0.05); the average time for healing was also significantly shorter in the treatment groups than in the control group (17.4, 16.8 vs. 23.6 days, respectively) (P<0.05). Our results suggest that topical application of ABS and TCC have beneficial effects on wound healing.

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