Dimitrinka ZAPRYANOVA, Nikolina RUSENOVA, Georgi BEEV, Parvan PARVANOV, Teodora MIRCHEVA, Stefan DENEV, Dian GEORGIEV

Changes in the activity of aspartate- and alanine aminotransferase in dogs with experimentally induced staphylococcus aureus infection

Bu çalışmanın amacı köpeklerde deneysel Staphylococcus aureus enfeksiyonunda aspartat aminotransferaz (AST) ve alanin aminotransferaz (ALT) plazma knosantrasyonlarını değerlendirmektir. AST, ALT ve solunum oranı (RR), nabız oranı (PR) ve vücut iç sıcaklığı (IBT) arasındaki ilişki ayrıca değerlendirildi. Bakteri süspansiyonu (of 3.1x109 cfu/mL) 9 adet melez 2 yaşlı erkek köpeğe subkutan yolla enjekte edilirken 6 adet diğer köpek negatif kontrol olarak kullanıldı. Konsantrasyonlar 0, 6, 24, 48 ve 72 saat ile 7, 14, 21. günlerde uygulamadan önce ticari kitler kullanılmak suretiyle belirlendi. Aminotrasferaz konsantrasyonları kontrole oranla enfekte köpeklerde daha yüksekti. AST 7. ve 14. günlerde, ALT ise 72. saatte en yüksek konsantrasyonlarda belirlendi. ALT ile AST konsantrasyonları arasında ve RR ile IBT arasında güçlü ilişki belirlendi. Transaminaz aktivitelerinin köpeklerde deneysel olarak oluşturulan Syafilokokal enfeksiyonu ile az derecede etkilendiği gözlemlendi.

Köpeklerde deneysel oluşturulan staphylococcus aureus enfeksiyonunda aspartat ve alanin aminotransferaz aktivitelerindeki değişimler

The main purpose of this study was to evaluate the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) plasma concentrations in dogs with experimentally-induced Staphylococcus aureus infection. Correlations between AST, ALT and Respiratory Rate (RR), Pulse Rate (PR) and Internal Body Temperature (IBT) were also calculated. Bacterial suspension with density of 3.1x109 cfu/mL was subcutaneously injected to 9 mongrel 2 years old male dogs whereas 6 other dogs served as negative controls. The concentrations were determined using commercial kits before application (0 h), 6, 24, 48, 72 h and 7, 14, 21 days after. The aminotransferase concentrations were higher in infected dogs than in the controls - AST peaked on days 7 and 14, and ALT - at the 72nd h. Strong positive correlations were recorded between ALT and AST concentrations and between RR and IBT. It was observed that the transaminases activities were slightly affected by the experimentally induced staphylococcal infection in dogs.

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