Duygu ÇAKIROĞLU, YÜCEL MERAL, UTKU BAKIREL, Didem KAZANCI

Cardiac troponin levels in dogs with dilate cardiomyopathy

Bu çalışmada, DCM’li köpeklerde plazma cTnI ve cTnT konsantrasyonlarının belirlenmesi ve bu tip kalp hastalıklarında bu iki parametrenin öneminin araştırılması amaçlanmıştır. Bu amaçla, belirgin klinik kalp hastalığı semptomlarının yanısıra, elektrokardiyografik ve ekokardiyografik muayenelerle DCM teşhisi konmuş farklı ırklardan 11 köpek kullanıldı. Serum CK, cTnI ve cTnT değerleri arasındaki korelasyon katsayıları önemsiz olarak hesaplandı ve bu değerler arasında önemli bir ilişki saptanmadı. DCM’li 11 köpeğin 10’unda (%90.9) yüksek cTnI seviyeleri gözlenirken, 7’sinde (%63.6) yüksek cTnT seviyeleri belirlenmiştir. Sonuç olarak, kardiyak Troponinlerin, özellikle cTnI’nın hayvanlarda önemli bir kardiyak belirleyici olmaya aday olduğu düşünülmektedir.

Anahtar Kelimeler:

kan plazması, troponin, köpek, teşhis, kreatin kinaz, kardiyomiyopati, kalp hastalıkları

Dilate kardiyomiyopatili köpeklerde kardiyak troponin seviyeleri

This study was designed to determine plasma cTnI and cTnT concentrations in dogs with DCM and to investigate the value of these two parameters in this type of heart disease. For this purpose, 11 dogs with DCM diagnosed, via electrocardiographic and echocardiographic examinations nearby apparent clinical heart disease symptoms were studied. The correlation coefficients between serum CK, cTnI and cTnT values were determined insignificant and no important relationship was calculated between these values. High cTnI levels were determined for 10 of 11 (90.9%) dogs with DCM, while high cTnT levels were determined for 7 of 11 (63.6%) dogs with DCM. It is suggested that cardiac Troponins, especially cTnI is a strong candidate as a cardiac biomarker in animals.

Keywords:

blood plasma, troponins, dogs, diagnosis, creatine kinase, cardiomyopathy, heart diseases,

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