Gulbin SENNAZLI, Ozge ERDOGAN-BAMAC, GÜLAY YÜZBAŞIOĞLU ÖZTÜRK, Lora KOENHEMSI

A Case of Polyostotic Fibrous Dysplasia in a Spider Monkey (Ateles paniscus)

This paper presents the gross and histopathologic findings of polyostotic fibrous dysplasia which is rarely seen in non-human primates. A 3-year-old female spider monkey (Ateles paniscus) was referred to the clinics of our faculty with the complaints of severe dyspnea, lethargy and cough and was diagnosed with dilated cardiomyopathy following the radiographic examination. However, the monkey died due to depression of respiration before treatment was done. Necropsy was performed on the request of the owner. Dilated cardiomyopathy and irregularly shaped tumoral masses with diameters of 0.5-1.0 cm in the right and left ribs were detected. Following the histopathological examination, the lesions were diagnosed as fibrous dysplasia.

Bir Örümcek Maymununda (Ateles paniscus) Poliostotik Fibröz Displazi Olgusu

Bu bildiri, insan olmayan primatlarda nadir olarak görülen polyostotik fibröz displazinin makroskobik ve histopatolojik bulgularını sunmaktadır. Üç yaşındaki dişi örümcek maymunu (Ateles paniscus) şiddetli dispne, letarji ve öksürük şikayetleri ile fakültemiz kliniklerine getirilmiştir. Yapılan radyografik muayene neticesinde dilate kardiyomiyopati teşhisi konulmuştur. Ancak, herhangi bir tedavi uygulanmadan önce, solunum yetmezliği sonucunda ölüm gerçekleşmiştir. Hasta sahibinin isteği üzerine uygulanan nekropside, dilate kardiyomiyopatinin yanısıra, sağ ve sol kostalarda çapları 0.5-1.0 cm arasında değişen, düzensiz şekilli tümoral kitleler tespit edilmiştir. Histopatolojik inceleme sonucunda lezyonlar fibröz displazi olarak teşhis edilmiştir.

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1. Fitzgerald W, Slocombe R, Caiafa A: Fibrous dysplasia of mandibular bone in a dog. J Vet Dent, 19 (2): 77-81, 2002. DOI: 10.1177/ 089875640201900203

2. DiCaprio MR, Enneking WF: Fibrous dysplasia. Patophysiology, evaluation, and treatment. J Bone Joint Surg Am, 87 (8): 1848-1864, 2005. DOI: 10.2106/JBJS.D.02942

3. Hartley I, Zhadina M, Collins MT, Boyce AM: Fibrous dysplasia of bone and McCune-Albright syndrome: A bench to bedside review. Calcif Tissue Int, 104, 517-529, 2019. DOI: 10.1007/s00223-019-00550-z

4. Riminucci M, Liu B, Corsi A, Shenker A, Spiegel AM, Robey PG, Bianco P: The histopathology of fibrous dysplasia of bone in patients with activating mutations of the Gsα gene: Site-specific patterns and recurrent histological hallmarks. J Pathol, 187, 249-258, 1999. DOI: 10.1002/(SICI)1096-9896(199901)187:2<249::AID-PATH222>3.0.CO;2-J

5. Dorfman HD: New knowledge of fibro-osseous lesions of bone. Int J Surg Pathol, 18 (Suppl. 3): 62S-65S, 2010. DOI: 10.1177/1066896910369924

6. Robinson C, Collins MT, Boyce AM: Fibrous dysplasia/McCuneAlbright syndrome: Clinical and translational perspectives. Curr Osteoporos Rep, 14, 178-186, 2016. DOI: 10.1007/s11914-016-0317-0

7. Charpurlat RD, Orcel P: Fibrous dysplasia of bone and McCuneAlbright syndrome. Best Pract Res Clin Rheumatol, 22 (1): 55-69, 2008. DOI: 10.1016/j.berh.2007.11.004

8. Wilson RB: Monostotic fibrous dysplasia in a dog. Vet Pathol, 26, 449450, 1989. DOI: 10.1177/030098588902600513

9. Raval SH, Joshi DV, Patel BJ, Sutariya P, Patel JG, Parmar SN: Monostotic fibrous dysplasia in the nasal sinus of Marwari mare: A case report. Indian J Vet Pathol, 39 (4): 358-359, 2015. DOI: 10.5958/0973970X.2015.00088.7

10. Soltero-Rivera M, Engiles JB, Reiter AM, Reetz J, Lewis JR, Sánchez MD: Benign and malignant proliferative fibro-osseous and osseous lesions of the oral cavity of dogs. Vet Pathol, 52 (5): 894-902, 2015. DOI: 10.1177/0300985815583096

11. Bauer C, Dunn BG, Brothman AR, Dick Jr EJ, Christensen C, Voges A, Moore CM: Polyostotic fibrous dysplasia in a cynomolgus macaque (Macaca fascicularis). Comp Med, 62 (2):142-148, 2012.

12. Duncan JR, Lederer HA, Ramsey FK, Tyler DE: Fibrous dysplasia in a monkey. Iowa State Univ Vet, 25, 81-82, 1962.

13. Williams WM, Lombard LS, Firfer HS: Fibrous dysplasia in a monkey and a kudu. J Am Vet Med Assoc, 147, 1049-1052, 1965.

14. Slayter MV, Boosinger TR, Pool RR, Dammrich K, Misdorp W, Larsen S: Histological classification of bone and joint tumors of domestic animals. In, World Health Organization. 2nd Series, Vol. 1, 9-11, Armed Forces Institute of Pathology, American Registry of Pathology, Washington DC, 1994.

15. Thompson KG, Dittmer KE: Tumors of bones. In, Meuten DJ (Ed): Tumors in Domestic Animals. 5th ed., 356-424, John Wiley&Sons, Inc., 2017.

16. Mahadevappa A, Patel S, Ravishankar S, Manjunath GV: Monostotic f ibrous dysplasia of the rib: A case report. Case Rep Orthop Res, 1-5, 2012. DOI: 10.1155/2012/690914

17. Traibi A, El Oueriachi F, El Hammoumi M, Al Bouzidi A, Kabiri EH: Monostotic fibrous dysplasia of the ribs. Interact Cardiovasc Thorac Surg, 14, 41-43, 2012. DOI: 10.1093/icvts/ivr048

18. Maki M, Saitoh K, Horiuchi H, Morohoshi T, Fukayama M, Machinami R: Comparative study of fibrous dysplasia and osteofibrous dysplasia: Histopathological, immunohistochemical, argyrophilic nucleolar organizer region and DNA ploid analysis. Pathol Int, 51, 603-611, 2001. DOI: 10.1046/j.1440-1827.2001.01252.x