Santral venöz kateterizasyonun önemli komplikasyonlarından biri de venöz trombozdur. Nadiren superior vena kava sendromu (SVKS) ile birlikte olabilir. Bu olgu sunumunda 54 yaşında acile siyanozla gelip solunum sıkıntısı nedeniyle yoğun bakıma alınıp port kateter venöz trombozu sonrası SVKS tanısı konan bir olguyu sunmayı amaçladık. 

One of the major complications of central venous catheterization is venous thrombosis. It can be rarely combined with superior vena cava syndrome (SVCS).  In this case report we aimed to present a 54-year old male patient who admitted emergency service and were taken to intensive care due to respiratory distress after venous thrombosis. The patient who underwent chemotherapy due to colon carcinoma had respiratory distress and cyanosis in his head and neck. Magnetic resonance angiography showed extensive thrombosis in his bilateral jugular veins, and the tissue plasminogen activator was administered by intraclot injection. After fibrinolytic therapy the patient’s symptoms and the signs of SVCS disappeared. Thrombolysis performed by interventional radiology is an effective method in the treatment of SVCS.