Fatih CANAN, Gjergji SINANI, Ünsal AYDINOĞLU

Transient normoprolactinemic galactorrhea induced by fluoxetine

Antidepresanlara bağlı hormonal yan etkiler sık görülmemektedir. Galaktore, antidepresanlara bağlı yan etkilerarasında nadiren bildirilmiştir. Antidepresanlar, hipotalamustaki postsinaptik 5-Hidroksitriptamin (5-HT) reseptörlerini doğrudan uyararak veya tuberoinfindibuler dopaminerjik nöronları 5-HT üzerinden dolaylı olarak inhibe ederek prolaktin seviyelerinde artışa ve sonuçta galaktoreye neden olabilirler. Ancak antidepresan tedavisi sırasında normal prolaktin seviyelerine rağmen galaktore gelişebilir.Bu çalışmada fluoksetin tedavisi ile ilişkili normoprolaktinemik galaktore gelişen bir kadın olgu sunulacaktır. Buolgu sunumu ile selektif serotonin gerialım inhibitörlerine bağlı galaktorenin tanımlanmamış mekanizmalarının varlığı üzerine vurgu yapılacaktır.

Fluoksetine bağlı, geçici normoprolaktinemik galaktore

Hormonal side effects of antidepressants are infrequent.Galactorrhea is rarely reported among antidepressantrelated side effects. Antidepressants can directly stimu-late postsynaptic 5- Hydroxytryptamine (5-HT) receptorsin the hypothalamus or indirectly inhibit the tuberoinfun-dibular dopaminergic neurons through 5-HT, which mayincrease prolactin levels and later cause galactorrhea.However, galactorrhea may develop despite normal prolactin levels during antidepressant treatment. We presenta case of normoprolactinemic galactorrhea in a woman,related with fluoxetine treatment. This report highlightsthe presence of unidentified mechanisms of selectiveserotonin reuptake inhibitor induced galactorrhea.

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