Mehmet TÜRKMEN, Belde KASAP, Gamze ÇAPAKAYA, Alper SOYLU, Demet ALAYGUT, Salih KAVUKÇU

Is there a correlation between the size of the BCG scar and renal scar of urinary tract infections in children?

Amaç: Pyelonefrit böbreklerde hücre ölümü ve skar gelişimine neden olmaktadır. Bu çalışmanın amacı, idrar yolu enfeksiyonu geçiren çocuklarda oluşan renal skar ile BCGskar boyutu arasında herhangi bir korelasyon olup olmadığını göstermektir. Bir korelasyon bulunması durumundaBCG skarı idrar yolu enfeksiyonu sonrası gelişen renal skarda belirleyici bir marker olarak kullanılabilecektir. Yöntemler: En az 4 ay önce idrar yolu enfeksiyonu geçirmiş, 99mTcDMSA sintigrafisi çekilmiş olan çocuk hastalar bu çalışmaya alındı Çalışma grubundaki hastaların BCG skarı vertikal ve horizontal çapta ölçüldü. İstatistiksel analiz için en büyük çap dikkate alındı ve ≤5 mm ve >5 mm olarak iki gruba ayrıldı. Hastalar renal skarı olanlar (Grup 1) ve renal skar geliştirmeyenler (Grup 2) olmak üzere iki grupta toplandı. Her iki grup, BCG skar boyutu ≤5 mm veya >5 mm olan gruplar ile karşılaştırıldı. Bulgular: 108 (82 kız) hasta çalışmaya dahil edildi. DM- SA’da skar olan toplam 51 hasta vardı. Skarı olan ve olmayan hastaların ortalama yaşları farklı değildi. (p=0,414) Renal skar bulunan ve bulunmayan gruplar arasında BCG skar boyutu bakımından istatistiksel olarak anlamlı bir fark bulunmadı (p>0,05). Tartışma: İdrar yolu enfeksiyonu geçiren çocuklarda renal skar gelişimi ile BCG skar boyutu arasında bir korelasyon bulunmadı.

Çocuklarda idrar yolu enfeksiyonu sonrası gelişen renal skar ile BCG skarı boyutu arasında bir ilişki var mıdır?

Objective: Pyelonephritis cause cellular death, and de-velopment of scars in kidneys. The aim of this study is todemonstrate a correlation (if any) between renal scar, andsize of the scar induced by BCG vaccine in children whohad experienced urinary tract infections. In case of detec-tion of any correlation, BCG scar formation can be usedas a determinative marker of renal scars, which developfollowing urinary tract infection.Methods: Patients with a history of urinary tract infection at least 4 months old who had undergone 99mTcDMSA scanning were included in this study. Vertical and hori- zontal diameters of BCG scars of the patients in the study group were measured. For statistical analysis the greatest diameter was taken into consideration, and the patients were divided into 2 subgroups based on the greatest di- ameter of their BCG scars (Subgroups 1, ≤5 mm, and 2, >5 mm). The patients were also evaluated in 2 groups as those with (Group 1) or without (Group 2) scars. Both groups were compared with subgroups with the largest scar diameters of ≤ 5mm or >5 mm Results: Study population included 108 (82 girls) pa- tients. DMSA detected scars in a total of 51 patients. Mean ages of the patients with and without scars were not different (p=0.414). No significant difference was found in size of the BCG scars between renal scar positive and negative groups (p>0.05). Conclusion: No correlation was found between develop- ment of renal scar and the size of BCG scar in children after urinary tract infection. J Clin Exp Invest 2013; 4 (1): 8-12

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