Harun AĞCA, Arzu Etem AKAĞAÇ, Güliz Doğan TOKLU

Brusellozda spesifik olmayan laboratuvar testlerinin tanıdaki önemi

Amaç: Brusella enfeksiyonlarının ayırt edici klinik özelliği olmadığından, ateşle seyreden hastalıklarla karışır. Bu çalışmada, brusellozlu hastalarda tanıya spesifik olmayan laboratuvar testlerinin tanıdaki değerini saptamak amaçlanmıştır. Gereç ve yöntem: Aralık 2010-Mayıs 2011 tarihleri arasında Uşak Devlet Hastanesi Merkez Laboratuvari’na gelen, klinik olarak brusellozla uyumlu, Standart Tüp Aglütinasyon (STA) testi ve Coombslu STA testi çalışılan hasta örnekleri geriye dönük olarak tarandı. Kontrol grubu olarak Aralık 2010-Mayıs 2011 tarihleri arasında laboratuvara başvuran, STA testi sonucu negatif olan, bruselloz tanısı olmayan 62 hasta rastgele belirlendi. Bulgular: Hasta grubunun 54’ünde (%87.0) CRP yüksekliği, 44’ünde (%70.9) ESH yüksekliği, 22’sinde (%35.4) AST yüksekliği, 7’sinde (%11.2) ALT yüksekliği, 19’unda (%30.6) Ferritin yüksekliği, 8’inde (%12.9) anemi saptandı. Kontrol grubunun 7’sinde (%11.2) CRP yüksekliği, 10’unda (%16.1) ESH yüksekliği, 1’inde (%1.6) AST yüksekliği, 1’inde (%1.6) ALT yüksekliği, 6’sında (%9.6) anemi saptanırken, ferritin düşüklüğü saptanan hasta olmadı. Sonuç: Sonuç olarak, brusellozda tanıya spesifik testlerin yanında, çalışmamızda istatistiksel olarak anlamlı bulunan CRP, ESH, ALT, AST ve ferritin yüksekliğinin de tanıyı destekleyici testler olarak kullanılabileceği sonucuna varılmıştır.

Importance of nonspecific laboratory tests in Brucella diagnosis

Objectives: Brucella infection doesn’t have spesific clinical evidences, for this reason it can be confused with febrile diseases. In this study we aimed investigating the importance of diagnosis with nonspesific laboratory tests in brucellosis. Materials and methods: We retrospectively screened clinically compatible with brucellosis, standard tube agglutination (STA) and STA tests with coombs of patients sera which came to Uşak State Hospital Central Laboratory between December 2010-May 2011. As control group, we determined random 62 patients attended to the laboratory between December 2010-May 2011 with STA test results are negative and not diagnosed brucellosis. Results: C-reactive protein elevated in 54 patients (87.0%), ESR elevated in 44 patients (70.9%), AST elevated in 22 patients (35.4%), ALT elevated in 7 patients (11.2%), ferritin elevated in 19 patients (30.6%), 8 patients had anemia (12.9%) of patient group. In control group, 7 patients elevated CRP (11.2%), 10 patients elevated ESR (16.1%), 1 patient elevated AST (1.6%), 1 patient elevated ALT (1.6%), 6 patients had anemia (9.6%) and decrease in ferritin level wasn’t detected. Conclusion: We concluded statistically significant high level of CRP, ESR, ALT, AST and ferritin support the test results too beside the spesific brucellosis tests. J Clin Exp Invest 2012; 3(1): 87-90

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