Şule BİLEN, AKAGÜNDÜZ EGE Ayşegül, Fikri AK

Assessment of prolactin associated platelet activation in ischemic stroke

Amaç: İskemik inme ile prolaktin seviyeleri, prolaktin ilişkili platelet aktivasyonu arasında ilişki olup olmadığı ve iskemik inme etyolojisinde rolleri olup olmadığının araştırılmasını amaçladık. Gereç ve yöntem: Çalışmaya akut iskemik inme tanısı almış olan 57 hasta ile iskemik vasküler hastalık hikayesi olmayan, yaş ve cinsiyet uyumlu 43 kontrol olgusu dahil edildi. Hastaların 12 saat açlığı takiben değerlendirilen prolaktin seviyeleri, platelet sayısı ve platelet aktivasyonunun bir göstergesi olan ortalama platelet hacmi (OPH) kontrol grubunun ölçümleri ile karşılaştırıldı. Bulgular: Hastaların prolaktin seviyeleri anlamlı şekilde yüksekti. Prolaktin seviyeleri ile erken OPH ölçümleri arasında bir ilişki bulunmadı. OPH açısından bir fark yok iken platelet sayısı hasta grubunda anlamlı şekilde yüksekti. Sonuç: Bu çalışmada prolaktinin ortalama platelet hacmi üzerinde bir etkisinin varlığı veya erken iskemik inme ve OPH arasında bir ilişki gösterilememiştir. Ancak iskemik inmeli hastalarda, erken dönemde yüksek prolaktin seviyesi ve yüksek platelet sayısı varlığı iskemik olayların etyolojisinde anlamlı olabilir. Bunun yanı sıra iskemik inmenin erken döneminde yüksek prolaktin seviyesi bulunması iskemik inmenin patogenezinde prolaktin artışının rolü olabileceğini düşündürebilir.

İskemik inmede prolaktin ilişkili platelet aktivasyonunun değerlendirilmesi

Objectives: We aimed to investigate whether there were any relations between prolactin levels, prolactin associated platelet activation and ischemic stroke, and whether they had role in etiology of ischemic stroke. Materials and methods: Totally 57 patients with the diagnosis of acute ischemic stroke and 43 age and sex matched controls with no history of ischemic vascular diseases were included in the study. Prolactin levels, mean platelet volume (MPV) a marker of platelet activation, and platelet count, of the patients, after 12 hours of fasting, compared with the measurements of control group. Results: Patients had significantly higher prolactin levels. A correlation between prolactin levels and early measurements of MPV was not detected. While there was no difference in terms of MPV, the platelet count was significantly higher in the patient group. Conclusions: In the present study, the existence of an effect of prolactin on the mean platelet volume, or a relationship between early ischemic stroke and MPV could not be shown. However, in ischemic stroke patients, in early phase, presence of higher levels of prolactin and platelet count may be meaningful in etiology of ischemic events. Besides, presence of higher prolactin levels in early phase of ischemic stroke may lead to consider the potential role of prolactin elevation in ischemic stroke pathogenesis. J Clin Exp Invest 2012; 3(1): 1-6

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