Kürşat ÖZDİLLİ, Serdar ARİSAN, Damla BÜYÜKTUNÇER

E-cadherin molecular mechanism in prostate cancer

Prostat kanseri oldukça sık teşhis edilen erkek solid tümörlerindendir. 2002 yılında, sağlık istatistiklerine göre 189,000 kiflinin Amerika Birleşik Devletlerinde bu hastalıktan ötürü teflhis edildiği ve 30,200 tanesininde öleceği tahmin edilmektedir. Prostat kanserinde ölüm metastaz ile ilişkili olup, metastaz perinöral invasyon ile ilişkilendirilmektedir. Tümör belirteçleri biyolojik moleküller olup malign durumları ortaya çıkarmaktadır. Özellikle kanser taramalarında tanı ve tedavi açısından potansiyel avantajları söz konusudur. E-cadherin kanser terapilerini takip açısından umut vaadeden bir tümör belirtecidir. Bunun yanı sıra cadherinlerin fonksiyonel tümör oluflumunda araştırılması gündemde olan konulardan bir tanesidir. Özellikle invasiv veya metastatik tümörlerin fenotipik belirlemesinde önem kazanmışlardır. Bundan ötürü e-cadherin aktivitesinin klinik açıdan kullanılabilirliği üzerine birçok araştırma yapılmaktadır.

E-cadherinlerin prostat kanserinde moleküler mekanizması

Prostate cancer is the most commonly diagnosed noncutaneous malignancy in men in USA. In the year 2002, according to the health statistics 189,000 men in the United States are expected to be diagnosed with the disease and 30,200 men are expected to die of it. Mortality in prostate carcinoma is associated with metastasis and metastasis in prostate carcinoma is usually associated with perineural invasion, for it is the preferred mechanism of prostate cancer metastasis. Tumor markers are biological molecules that indicate the presence of malignancy. They are potentially useful in cancer screening, aiding diagnosis, assessing prognosis, predicting in advance a likely response to therapy, and monitoring patients before and after diagnosis. E-cadherin is a promising tumor marker for malignancies in lots of cancer types. Also, the cadherin functional implication in tumor malignancy is an exciting research area in tumor biology, and it is expected to give some insights into how tumors acquire an invasive and metastatic phenotype. Therefore, there are many investigations about E-cadherin activity and its future usage in clinics.

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