Nizamettin Gunbatar, Mehmet Salih KAYA, Tahir KAHRAMAN, Fahri BAYİROGLU

Paradoxical Advantage of Middle Aged Sedentary over Young Sedentary on Starting Exercise in Terms of GH/IGF-1 System

The aim of this study was to investigate the effects of the submaximal running exercise on the GH/IGF-1 axis in the middle aged sedentary nonobese and preobese males. 24 healthy volunteer males were divided into 2 groups and then 2 subgroups according to their age ranges (20-25 and 35-43) and Body Mass Indexes (BMI) (nonobese- NO and preobese- PO) respectively. All subjects underwent a submaximal running exercise for 30 minutes a day/ 4 days a week and for a period of 6 weeks. Serum GH, IGF-1, IGFBP-3, and insulin levels were measured in all subjects before and after the exercise program. IGFBP-3 levels were found to be statistically decreased in the PO middle aged and NO young groups whereas IGF-1 levels were statistically increased in NO young group after the exercise treatment. Surprisingly PO and NO middle aged groups’ Insulin and GH responses against exercise were quite opposite of those observed in young groups. In the light of the findings, it could be suggested that the middle aged group’s response against exercise on the base of GH/IGF-1 system was more effective than the young group, was found to be quite interesting.

Keywords:

Exercise preobese, middle aged, sedentary, GH/IGF-1 system,

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1. Utter AC, Whitcomb DC, Nieman DC, Butterworth DE. and Vermillion SS. 2000. Effects of exercise trainning on gallbladder function in an obese female population. Medicine Science in Sports Exercise. 32:141-145.
2. Pedersen BK, Saltin B. 2015. Exercise as medicine–evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports. 25(S3):1–72.
3. Poehlman ET and Copeland KC. 1990. Influence of physical activity on insulin-like growth factor-1 in healthy younger and older men. J Clin Endocrinol Metab. 82:2177-2181.
4. Mitchell JH, Tate C, Raven P, Cobb F, Kraus W, Moreadith R, O'Toole M, Saltin, B and Wenger N. 1992. Acute response and chronic adaptation to exercise in women.Med Sci Sports Exerc. 24:258-265.
5. Lalia AZ, Dasari S, Johnson ML, et al. 2016. Predictors of whole-body insulin sensitivity across ages and adiposity in adult humans. J Clin Endocrinol Metab. 101:626-634.
6. Byrne H, Caulfield B, De Vito G. 2018. Self-directed exercise programmes in sedentary middle-aged individuals in good overall health; a systematic review. Prev Med.114:156-163.
7. Byrne H, Caulfield B, De Vito G. 2017. Effects of Self-directed Exercise Programmes on Individuals with Type 2 Diabetes Mellitus: A Systematic Review Evaluating Their Effect on HbA1c and Other Metabolic Outcomes, Physical Characteristics, Cardiorespiratory Fitness and Functional Outcomes. Sports Med. 47(4):717-733.
8. Seals DR, Hagberg JM, Hurley BF, Ehsani AA. and Holloszy JO. 1984. Endurance training in older men and women, I. Cardiovascular responses to exercise. J Appl Physiol. 57:1024-1029.
9. American College of Sports Medicine Position Stand. 1998. The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults. Med Sci Sports Exerc. 30:975-991.
10. Mukherjee A, Shalet SM. 2009. The value of IGF1 estimation in adults with GH deficiency. Eur J Endocrinol. 161(1):33-9.
11. Sartorio A, Morpurgo P, Cappiello V, Agosti F, Marazzi N, Giordani C, Rigamonti AE, Muller EE, Spada A. 2008. Exercise-induced effects on growth hormone levels are associated with ghrelin changes only in presence of prolonged exercise bouts in male athletes. J Sports Med Phys Fitness. 48(1):97-101.
12. Grandys M, Majerczak J, Kuczek P, Sztefko K, Duda K, Zoladz JA. 2017. Endurance training-induced changes in the GH-IGF-I axis influence maximal muscle strength in previously untrained men. Growth Horm IGF Res. 32:41-48.
13. Ahtiainen JP, Pakarinen A, Kraemer WJ, Häkkinen K. 2004. Acute hormonal responses to heavy resistance exercise in strength athletes versus nonathletes. Can J Appl Physiol. 29(5):527-43.
14. Sheikholeslami-Vatani D, Ahmadi S, Salavati R. 2016. Comparison of the Effects of Resistance Exercise Orders on Number of Repetitions, Serum IGF-1, Testosterone and Cortisol Levels in Normal-Weight and Obese Men. Asian J Sports Med. 7(1):30503.
15. Thomas GA, Kraemer WJ, Comstock, BA, Lewis CD, Volek JS, Denegar CR. and Maresh CM. 2012. Effects of resistance exercise and obesity level on ghrelin and cortisol in men. Metabolism. 61:860-868.
16. Gregory SM, Spiering BA, Alemany JA, Tuckow AP, Rarick KR, Staab JS, Hatfield DL, Kraemer WJ, Maresh CM and Nindl BC. 2013. Exercise-induced insulin-like growth factor I system concentrations after training in women. Med Sci Sports Exerc. 45:420-8.
17. Mohajeri Tehrani MR, Tajvidi M, Kahrizi S and Hedayati M. 2015. Does endurance training affect IGF-1/IGFBP-3 and insulin sensitivity in patients with type 2 diabetes. J Sports Med Phys Fitness. 55:1004-12.
18. Copeland JL, Chu SY and Tremblay MS. 2004. Aging, physical activity, and hormones in women-a review. J Aging Phys Act. 12:101-16.
19. Silverman HG and Mazzeo RS. 1996. Hormonal responses to maximal and submaximal exercise in trained and untrained men of various ages.J Gerontol A Biol Sci Med Sci. 51:30-7.
20. Yamaguchi T, Saiki A, Endo K, Miyashita Y and Shirai K. 2011. Effect of exercise performed at anaerobic threshold on serum growth hormone and body fat distribution in obese patients with type 2 diabetes. Obesity Research & Clinical Practice. 5:9-16.
21. Kanaley JA, Frystyk J, Moller N, Dall R, Chen JW, Nielsen SC, Christiansen JS, Jorgensen JO and Flyvbjerg A. 2005. The effect of submaximal exercise on immuno- and bioassayable IGF-I activity in patients with GH-deficiency and healthy subjects. Growth Horm IGF Res.15:283-90.
22. Chadan SG, Dill RP, Vanderhoek K and Parkhouse WS. 1999. Influence of physical activity on plasma insulin-like growth factor-1 and insulin-like growth factor binding proteins in healthy older women. Mech Ageing Dev. 109:21-34.
23. Nelson RK, Horowitz JF. 2014. Acute exercise ameliorates differences in insulin resistance between physically active and sedentary overweight adults. Appl Physiol Nutr Metab. 39(7):811-8.