PANDEMİK H1N1 İNFLUENZA İNFEKSIYONLU HASTALARIN GENEL ÖZELLİKLERİ VE KLİNİK BULGULARI

Bu çalışmada; hastanemizde pandemik H1N1 influenza nedeniyle takip edilen hastaların klinik, radyolojik ve laboratuvar özelliklerinin değerlendirilmesi amaçlanmıştır. Kasım 2009 ile Aralık 2009 tarihlerini kapsayan dönemde acil servis, göğüs hastalıkları ve infeksiyon hastalıkları polikliniklerine başvuran, Sağlık Bakanlığı kriterlerine göre pandemik H1N1 influenza şüphesi ile kliniğimize yatırılan ve farinks sürüntü örneklerinde real-time reverse transkriptaz, polimeraz zincir reaksiyonu yöntemiyle H1N1 pozitifliği saptanan hastalar çalışmaya alındı. Hastaların laboratuar ve klinik bilgileri SPSS 15 programına yüklendi ve istatistiksel analizleri yapıldı. Yapmış olduğumuz çalışmaya 8'i erkek (%53.3), 7'si kadın (%46.7) toplam 15 hasta dahil edildi. Hastaların 4'ü yoğun bakımda takip edildi, bunlardan biri invaziv mekanik ventilatöre bağlandı. Hastaların 3'ü (%20) gebeydi. Hastaların %66'sında taşipne, %53'ünde dispne, %33'ünde burun akıntısı ve %100'ünde halsizlik şika yeti mevcuttu. Yapılan laboratuvar tetkiklerinde; hastaların %33'ünde hipoksi, %46'sında lökopeni ve trombositopeni, %20'sinde CRP yüksekliği, %46'sında akciğer grafisinde infiltrasyon saptandı. Yoğun bakımda takip edilen hastaların hepsinde lökopeni ve trombositopeni mevcuttu

Anahtar Kelimeler:

Pandemik H1N1influenza, klinik, laboratuvar özellikleri

THE GENERAL FEATURES AND CLINICAL FINDINGS OF PATIENTS WITH PANDEMIC H1N1 INFLUENZA VIRUSE INFECTION

In the study, it was aimed to evaluate the labaratory, clinical and radiological features of patients who were observed with the pandemic H1N1 influenza viruse infection in our hospital. Between November and December 2009, the patients, who have admitted to emergency, chest disease and infectious disease clinics and were hospitalized for suspect of the pandemic H1N1 Influenza Viruse infection according to the Ministry of Health Services criteria and established positive H1N1 viruse by real-time reverse transcriptase polymerase chain reaction test in pharyngeal swab samples, were included to the study. The laboratory and clinical data of patients was uploaded to SPSS 15 software and statistical analyse was performed. A total of 15 patients, in those 8 men (53.3%) and 7 women (46.7%), have been participated in the study. Four patients were observed in the intensive care unit and one of them was supported by invasive mechanical ventilator. Three patients (20%) were pregnant. 66% of patients had complained with tachypnea, 53% had dyspnea, 33% had nasal secretion, and 100% had fatigue. In the laboratory tests, 33% had hypoxia, 46% had leukopenia and thrombocytopenia, 20% had increased C-reactive protein and 26% of patients had infiltration on the chest roentgenography. All of the patients who were observed in the intensive care unit had leukopenia and thrombocytopenia

Keywords:

Pandemic H1N1influenza infection, clinical and laboratory features,

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1. Tuite AR, Greer AL, Whelan M, et al. Estimated epidemiologic parameters and morbidity associa-ted with pandemic H1N1 influenza. CMAJ 2010; 182(2): 131-6.
2. Özbek S. Domuz Kaynakl› ‹nfluenza A (H1N1) Virus Enfeksiyonu: Radyolojik Bak›fl. Selçuk T›p Derg 2010; 26(1): 32-4.
3. Agarwal PP, CintiS, Kazerooni EA. Chest radiographic and CT findings in novel swine origin influenza A (H1N1) virus S-OIV) infection. Am J Roentgenol 2009; 193: 1488-93.
4. Cao B, Li XW, Mao Y, et al. National Influenza A Pandemic (H1N1) 2009 Clinical Investigation Group of China: Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China, N Engl J Med 2009; 361(26): 2507-17.
5. Badur S. H1N1 Epidemiyolojisi ve Virüs. ANKEM Derg 2010; 24: 190-5.
6. Word Health Organization: Situation update in the European Region: overview of influenza surveillance data week 40/2009 to week 07/2010, www.euroflu.org.
7. Salto¤lu N, Balkan ‹‹. H1N1: Klinik Görü- nümler. ANKEM Derg 2010; 24: 196-200.
8. Peiris JS, Poon LL, Guan Y. Emergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans. J Clin Virol 2009; 45: 169-73.
9. Perez-Padilla R, de la Rosa-Zamboni D, Ponce de Leon S, Hernandez E, Quinones-Falconi F, Bautista E. Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico. N Engl J Med 2009; 361: 680-9.
10. TC Sa¤l›k Bakanl›¤› Temel Sa¤l›k Hizmetleri Genel Müdürlü¤ü-Pandemik Koordinasyon Birimi: Pandemi Bilim Kurulu toplant›s› sunumu, Ankara, 24 Aral›k (2009).