EKSTRAPULMONER TÜBERKÜLOZDA CİNSİYET FARKLILIĞI
Ekstrapulmoner tüberkülozun (EPT) klinik görünümlerinde cinsiyet farklılığını araştırmak amaçlanmıştır. Ocak 2000-Ocak 2004 tarihleri arasında dispanserimizde tedavi ve izlemi yapılan 137 EPT'li olgunun kayıtları retrospektif olarak incelendi. Olgularımızın 71 (%51.82)'i erkek 66 (%48.17)'sı kadın olup, erkeklerin yaş ortalaması 35.25± 16.02, kadınların yaş ortalaması 38.95±17.82 idi. Her iki cinste de en sık görülen EPT formları plevra ve lenf bezi tüberkülozu iken, plevra tüberkülozu erkeklerde (%67.60-%40.90, p=0.002), lenf bezi tüberkülozu kadınlarda (%31.81-%11.26, p=0.017) daha yüksek oranlarda saptandı. Akciğer tüberkülozu birlikteliği erkeklerde daha fazlaydı (%21.21-%8.45). Her iki cinste en sık izlenen semptomlar gece terlemesi, öksürük ve göğüs ağrısı idi. Erkeklerde göğüs ağrısı (p=0.046) ve balgam çıkarma (p=0.021), kadınlarda lenfadenopatiye bağlı ele gelen şişlik (p=0.003) yakınması daha fazlaydı. Temas öyküsü kadınlarda (%27.27- %21.12), daha fazla iken, tüberküloz geçirme öyküsü yalnız erkeklerde (%8.45) vardı. Kadınlarda ve erkeklerde, EPT'nin klinik görünümlerinde belirgin farklılıklar vardı. Her iki cinste de plevra tüberkülozu en sık EPT formu iken lenf bezi tüberkülozu kadınlarda erkeklere göre yaklaşık üç kat fazla saptandı.
GENDER DIFFERENCES IN EXTRAPULMONARY TUBERCULOSIS
To e valuate gender differences in the clinical manifestations of extrapulmonary tuberculosis (EPT). Records of 137 cases with EPT reviewed retrospectively which were treated and followed up in our dispensary between January 2000- December 2003. 71 of our cases were male, 66 were female and the mean age was 35.25±16.02 in males and 38.95±17.82 in females. While the most common EPT forms were pleural and lymph node tuberculosis in both sexes, pleural tuberculosis was more in males (67.60%-40.90%, p=0.002), and lymph node tuberculosis was more in females (31.81%-11.26%, p=0.017). Accompanying lung tuberculosis was more in males (21.21%-8.45%). The most common symptoms in both sexes were night sweating, cough and chest pain. Chest pain (p=0.046) and sputum expectoration (p=0.021) were more in males, palpable lymphadenopathy(p=0.003) was more in females. While the history of contact was more in females, history of tuberculous disease was found only in males. There were significant clinical differences between females an d males. While the most common form of EPT was pleural tuberculosis in both genders, lymph node tuberculosis was found approximately three times more in females.
___
- 1. Lauzardo M, Askhin D. Phthisiology at the
down of the century. A review of tuberculosis
and prospects for its elimination. Chest
2000; 117: 1455-73.
- 2. Yang Z, Kong Y, Wilson F, et al. Identification
of risk factors for extrapulmonary tuberculosis.
Clin Infect Dis 2004; 38: 199-205.
- 3. American Thoracic Society. Diagnostic
standards and classification of tuberculosis
in adults and children. Am J Respir Crit Care
Med 2000; 161: 1376-95.
- 4. Gender and Tuberculosis. World Health
Organization 2003. Accepted from http://
www.who.int/gender/documents/en/TB.
factsheet.pdf
- 5. Frank G. Lung disease in women. Winter
2002; 6(1): 40-3.
- 6. Martinez AN, Rhee JT, Small PM, Behr MA.
Sex differences in the epidemiology of
tuberculosis in San Francisco. Int J Tuberc
lung Dis 2000; 4(1): 26-31.
- 7. Salim Hamid MA, Declarcq E, Deun AV, Saki
KAR. Gender differences in tuberculosis: a
prevalence survey done in Bangladesh. Int J
Tuberc lung Dis 2004; 8(8): 952-7.
- 8. Özkara fi. K›l›çaslan Z, Öztürk F, Seymeno¤lu
S ve ark. Bölge verileriyle Türkiye’de tüberküloz.
Toraks Dergisi 2002; 3(2): 178-87.
- 9. Akto¤u S, Yorganc›o ¤lu A, Ç›rak K, Dereli fi.
Clinical spectrum of pulmonary and pleural
tuberculosis: a report of 5480 cases. Eur
Respir J 1996; 9: 2031-5.
- 10. Balbay Ö, Ifl›khan V, Annakaya AN ve ark.
Düzce T›p Fakültesi Dergisi 2004; 2: 5-14.
- 11. Caracta CF. Gender differences in pulmonary
disease. The Mount Sinai Journal of
Medicine 2003; 70(4): 215-24.
- 12. Holmes CB, Hausler H, Nunn P. A review of
sex differences in the epidemiology of tuberculosis.
In J Tuberc Lung Dis 1998; 2: 96-
104.
- 13. Boore MJ, Harries AD, Godschalk P, et al.
Gender differences in relation to sputum
submission and smear positive pulmonary
tubercolosis in Malawi. In J Tuberc Lung Dis
2000; 4(9): 882-4.
- 14. Thorson A, Diwan VK. Gender inequatities in
tuberculosis: aspects of infection, notificztion
rates and compliance. Curr Opin Pulm
Med 2001; 7(3): 165-9.
- 15. Uplekar MW, Rangen S, Weiss MG, et al.
Attention to gender issues in tuberculosis
control. Tuber Lung Dis 2001; 5(3): 220-4.
- 16. Hudelson P. Gender differentials in tuberculosis:
the role of socio-economic and cultural
factors. Tuber lung Dis 1996; 77(5): 391-400.
- 17. Begum V, de Colombani P, Das Gupta S, et
al. Tuberculosis and patient gender in
Bangladesh: sex differences in diagnosis
and treatment outcome. J Tuberc Lung Dis
2001; 5(7): 604-10.
- 18. Gonzales OY, Adams G, Teeter LD, et al.
Extrapulmonary manifestations in a large
metropolitan area with a low incidence of
tuberculosis. Int J Tuberc Lung Dis 2003; 7
(12): 1178-85.
- 19. Hesselink DA, Yoo SM, Verhoeven GT, et al.
A high prevalence of culture-positive
extrapulmonary tuberculosis in a large Duth
teaching hospital. Netherlands The Journal
of Medicine 2003; 67(3): 65-70.
- 20. Beek LAM, Werf MJ, Richter C, Borgdorff
MW. Extrapulmonary tuberculosis by nat›onal›ty,
the Netherlands, 1993-2001. Emerging
Infectious Diseases 2006: 12(9): 1375-82.
- 21. Saman Y, Krayem A, Haider M, et al
Treatment outcome of tuberculosis among
Saudi nationals: role of drug resistance and
compliance. Clin Microbiol Infect 2003; 9:
289-94.
- 22. Tatar D, Coflkunol ‹, Ayd›n M ve ark. ‹zmir
Eflrefpafla Verem Savafl Dispanserinde 1995-
2000 y›llar› aras›nda izlenen ekstrapulmoner
tüberküloz olgular›n›n retrospektif analizi.
Akci¤er Arflivi 2001; 3: 107-12.
- 23. Forssbohm M, Zwahlen M, Loddenkemper
R,. Rieder HL. Demographic haracteristics of
patients with extrapulmonary tuberculosis in
Germany. Eur Respir J 2008; 31: 99-105.
- 24. Rieder HL, Snider DE Jr, Cauthen GM.
Extrapulmonary tuberculosis in the United
States. Am Rev Respir Dis 1990; 41: 347–
51.
- 25. Tam CM, Leung CC, Noertjojo K, Chan SL,
Chan-Yeung M. Tuberculosis in Hong Kongpatient
characteristics and treatment
outcome. Hong Kong Med J 2003; 9: 83-90
- 26. Özbay B, Uzun K. Extrapulmonary tuberculosis
in high prevalence of tuberculosis
and low prevalence of HIV. Clin Chest Med
2002; 23: 351-4.
- 27. Peto HM, Pratt RH, Harrington TA, LoBua PA,
Armstrong LR. Epidemiology of
extrapulmonary tuberculosis in the United
States, 1993-2006. Clin Infect Dis 2009 Nov
1; 49(9): 1350-7.
- 28. Fiske TC, Griffin MR, rin H, Warkentin J,
Lisa K, Arbogast PG, Sterling TR. Black race,
sex, and extrapulmonary tuberculosis risk:
an observational study. BMC infectious
Diseases 2010; 10-23.