Mehmet ÇALAN, Aslı GÜLER BAYINDIR, Ozge DOKUZLAR, Pınar YEŞİL, Tuğba ARKAN, TUNCAY KÜME, Ahmet Murat IŞIL, Fırat BAYRAKTAR

RELATIONSHIP BETWEEN CIRCULATING BETATROPHIN LEVELS AND INSULIN RESISTANCE IN PREDIABETIC SUBJECTS

nroduction: Betatrophin [also known as RIFL, lipasin, ANGPTL8, TD26] is newly appreciated for its role as a potent inducer of beta cell proliferation in mice. Its expression is increased upon insulin resistance.We here aimed to determine the serum levels of this hormone in prediabetic subjects and to investigate its relationship with metabolic parameters. Material and Methods: The research was designed as a case-control study, in which 42 subjects with prediabetes and 37 with normal glucose tolerance were consecutively recruited, in an attempt to match the groups for age, sex and body mass index (BMI). Serum betatrophin, insulin, C-peptide, fasting blood glucose, HbA1c, high-sensitivity C-reactive protein, and lipid levels were measured. Insulin resistance was evaluated using the HOMA-IR index. Results: Serum betatrophin levels were significantly higher in prediabetic subjects compared with normal glucose-tolerant subjects (p

PREDİYABETİK HASTALARDA BETATROPHİN DÜZEYİ İLE İNSÜLİN DİRENCİ ARASINDAKİ İLİŞK

Giriş: Betatrophin farelerde beta hücrelerinde proliferasyona neden olmakta ve insulin direnci ile sentezi artmaktadır. Araştırmamızda prediyabetik hastalarda serum betatrophin düzeyini incelemeyi ve betatrophinin metabolik parametreler ile ilişkisini incelemeyi amaçladık. Gereç ve Yöntem: Vaka kontrollü olarak planladığımız araştırmamıza; 42 prediyabetik hasta ve yaşı, çinsiyeti ve vücut kitle indexi (VKİ) uygun olan 37 gönüllü glukoz metabolizması normal olan birey alındı. Araştırmaya dâhil edilen bireylerin betatrophin, insulin, C-peptit, açlık kan glikozu, HbA1c, hs-CRP ve lipid düzeyleri ölçüldü. Bireylerin insulin dirençleri HOMA-IR indexi ile hesaplandı. Bulgular: Serum betatrophin düzeyi prediyabetik bireylerde kontrol grubundaki bireylere göre istatistiksel olarak anlamlı yüksek bulundu (p

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