Tuğba ARKAN, Mehmet ÇALAN, Dilek ÇIMRIN, Pınar YEŞİL, Fırat BAYRAKTAR

COMPENSATORY INCREASED IRISIN LEVELS IN GESTATIONAL DIABETES MELLITUS

Introduction: Irisin, a newly discovered hormone, is secreted by skeletal muscles into circulation. It is proposed to regulate energy homeostasis and hold therapeutic potential in diabetes and obesity. Irisin increases thermogenic energy expenditure via increasing uncoupling protein 1 (UCP1) expression. We aimed to investigate the association of irisin and uncoupling protein 1 (UCP1) with gestational diabetes mellitus (GDM). Material and Methods:The research was designed as a cross-sectional and observational study conducted in a university hospital. A total of 61 pregnant women (30 GDM; 31 non-GDM) along with 41 age-matched nonpregnant controls participated in the study. Plasma irisin, serum UCP1, insulin, fasting blood glucose (FBG) and lipids were measured. Results:Irisin levels were significantly higher and UCP1 levels lower in the GDM group, compared with both the non-GDM and the control groups (P

GESTASYONEL DIYABETES MELLITUSTA İRİSİNİN KOMPENZATUVAR OLARAK ARTMASI

Giriş: İrisin kastan dolaşıma salgılanan yeni keşfedilmiş bir hormondur. İrisinin enerji dengesinin sağlanmasında rol aldığı düşünülmektedir, bu nedenle diyabet ve obezitenin tedavisinde etkili olma potansiyeli olan bir hormondur. İrisin uncoupling protein 1 ekpresyonunu artırarak ısı yolu ile enerji tüketimini artırmaktadır. Bizde araştırmamızda gestasyonel diyabetes mellituslu (GDM) kadınlarda irisin ve uncoupling protein 1 arasındaki ilişkiyi inceledik. Gereç ve Yöntem: Araştırmamız kesitsel ve gözlemselbir araştırma olarak planlandı. Araştırmamıza toplamda 61 gebe kadın (30 GDM, 31 GDM olmayan kadın)ve 41 benzer yaşta gebe olmayan kadın kontrol grubu olarak alındı. Bireylerin plazma irisin, serum UCP1, insulin, açlık kan şekeri ve lipid düzeyleri ölçüldü. Bulgular: GDM’li kadınlarda gestasyonel diyabeti olmayan kadınlara ve gebe olmayan kadınlara göre irisin düzeyi istatistiksel olarak anlamlı yüksek, UCP1 düzeyi ise istatistiksel olarak anlamlı düşük saptandı (P

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