Sinem Özlem ENGİNLER, Kıvılcım SÖNMEZ, Ahmet SABUNCU, Seçkin Serdar ARUN

İstanbul Üniversitesi Veterinary Medicine Istanbul University

Bir Köpekte Ovarian Granüloza Hücre Tümörü ve Kompleks Meme AdenokarsinomuOn bir yaşlı boxer köpek rutin kısırlaştırma için Doğum ve Jinekoloji Anabilim Dalı kliniğine getirildi ve histopatolojik olarak granüloza hücre tümörü (GHT) olarak teşhis edilen bir kitle tesadüfen saptandı. Ameliyat esnasında hormonal analiz için kan örneği toplandı ve bu kan örneğinde östrojen konsantrasyonu referans değerlerin altında, progesteron konsantrasyonu ise normal olarak tespit edildi. Köpeğin ilk muayenesi esnasında meme bezlerinde genişlemeler tespit edildi ve herhangi bir vulvar akıntı/şişlik tespit edilmedi. Kısırlaştırmayı takiben bir ay sonra köpek total bilateral mastektomi için kliniğimize tekrar getirildi. Histopatolojik olarak tümörel kitleler kompleks adenokarsinom tip II olarak tespit edildi. Köpekte hem GHT hem de meme tümörü aynı anda bulunduğu halde, GHT'nün köpek meme tümörü gelişimi üzerine etkisi tam anlamıyla anlaşılamadı. Serum östrojen ve progesteron konsantrasyonlarının referans değerlerden yüksek olmamasına bağlı olarak, GHT'nün henüz hormon salgılamadığı düşünüldü. Sonuç olarak, bu olgu GHT'nün köpek meme tümörünün gelişimi üzerine olası etkisinden bahsetmesinden ve köpekte meme tümörü varlığında bu hastalığın göz ardı edilmemesi gerekliliğini önermesinden dolayı önemlidir.

Ovarian Granulosa Cell Tumor and Complex Mammary Adenocarcinoma in a Bitch

An 11-year old boxer bitch was presented to the Department of Obstetrics and Gynaecology clinic for routine ovariohysterectomy and coincidentally an ovarial mass was detected which was diagnosed as granulosa cell tumor (GCT) in pathologic examinations. Blood sample was collected for hormonal analysis during this surgery in which estrogen concentration was under the reference range, progesterone concentration was normal. Mammary gland enlargements were also detected on the dog during initial examination with no other sign regarding to vulvar discharge/swelling. One month later following ovariohysterectomy, the dog was presented again for bilateral total mastectomy. Tumoral tissues were diagnosed as complex adenocarcinoma grade II, histopathologically. The possible interaction and promotional effect of GCT on the development of mammary tumors (MTs) is not yet fully understood. Regarding to serum estrogen and progesterone concentrations were not above the reference ranges suggest us GCT did not secrete hormones yet. In conclusion, this case is important as it reports the possible effect of GCT on the development of MTs and suggests not to ignore this disease in a dog with mammary tumours.

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