Abdolah MIRZAEI, Hasan SHARIFIYAZDI, Tahereh ARAROUTI

Assessment of single nucleotide polymorphism in the 5'-flanking region of insulin-like growth factor-I (IGF-I) gene as a potential genetic marker for fertility in Holstein dairy cows

İnsulin benzeri büyüme faktörü-I (IGF-I) inek fertilitesinde kritik bir rol oynayan en önemli metabolik faktörlerden birisidir. Son yıllarda IGF-I geninin 5’- kodlanmayan bölgesinde (5’-UTR) 512. nükleotid pozisyonundaki (C/T dönüşümü) nokta mutasyonu oldukça ilgi çekmiştir. Bu tip mutasyon ile süt ineği serumundaki IGF-I konsantrasyonu arasında önemli bir ilişki bulunduğu bildirilmiştir. Bu nedenle İran Siyah Alaca sütçü ineğine ait bazı reprodüktif parametreler ile IGF-I geninin 5'-UTR bölgesinde 512. nükleotidindeki polimorfizm arasındaki ilişkiyi inceledik. Kan örnekleri, daha önceki laktasyonlarında istenilen düzeyde fertilite gösteren (SPC

Siyah Alaca sığırlarında insülin benzeri büyüme faktörü -I (IGF-I) geninin 5'- sınırdaş bölgesindeki tek nükleotid polimorfizminin fertilite için potansiyel genetik markır olarak değerlendirilmesi

Insulin-like growth factor-I (IGF-I) is one of the most important metabolic factors that plays a critical role in cow fertility. Recently, point mutation of IGF-I gene at nucleotide position 512 (C/T transition) within the 5′-untranslated region (5'-UTR) has attracted the most attention. It has previously been demonstrated that there was an important relationship between this type of mutation and IGF-I concentration in dairy cows serum. Hence, we investigate the relationship between polymorphism within 512 of the 5'-UTR of IGF-I gene and some reproductive parameters in Iranian Holstein dairy cows. Blood samples were collected from 60 multiparous cows with a history of desirable fertility (SPC

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