N. Yakut ÖZGÜR, Hüseyin YILMAZ, Süleyman K. TEKELİ

Akut faz proteinleri ve infeksiyöz hastalıklardaki önemi

Akut faz yanıt, organizmada infeksiyon, yangı ve doku hasarı (eklem hastalıkları) olduğu durumlarda oluşmaktadır. Eğer infeksiyon ve yangı uzun süre devam ederse sonuçta amiloidozis şekillenmektedir. Amiloidozis başta köpek ve kedilerde olmak üzere bazen atlarda ve koyunlarda da görülmektedir. Akut faz yanıtta, kanda akut faz proteinlerinin (C-reaktif protein, haptoglobin, serum amyloid A, fibrinojen ve seruloplazmin) düzeyleri artmaktadır. Bu proteinlerin kandaki miktarının ölçümü ile organizmada infeksiyon, yangı, doku hasarı ve amiloidozisin tanısı konulabilir. Eğer infeksiyonlarda sağaltım denenmiş ise sağaltımda başarılı olunup olunmadığı da ortaya konula¬bilir. Mezbahalarda infekte karkasların ortaya çıkarılmasında da bu proteinlerin ölçümü yarar sağlamaktadır. Bu derlemenin amacı, Veteriner sahada bu konuda yapılan çalışmaların özünü vermek ve akut faz proteinlerinin ölçülmesine yönelik çalışmaların hayvan hastalıklarında da kullanılmasının yararlı olacağını vurgulamaktır.

Acute phase proteins and it'simportance in infectious diseases

Acute phase response occurs in infection, inflamation and tissue damage (joint diseases). Chronic infections and inflamations results in amyloidosis which is mainly seen in dogs and cats, and occasionally in horses and sheep. In acute phase response, the level of acute phase proteins in blood such as C-reactive pro¬tein, haptoglobin, serum amyloid A, fibrinogen and ceruloplasmin increases. Therefore, the meas¬urement of the level of acute phase proteins in blood during infection, inflamation and tissue dam¬age is important for the diagnosis. If the treatment has been tried, the success of the treatment can also be evaluated. In addition, infected carcasses in the slaughterhouses can be detected by meas¬uring the acute phase proteins before slaughtering. The aim of this rewiev is to summarize the studies in Veterinary field in acute phase pro¬teins. We believe that it will be useful to start using the measurement of acute phase proteins in diagnosis of diseases in domesticated animals.

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