R-ORANI, COVID-19 TEDAVİSİNDE AKUT KARACİĞER HASARININ BİR GÖSTERGESİ OLABİLİR Mİ?

Amaç: Çalışmanın amacı, COVID-19 hastalarında R oranının bir gösterge olup olamayacağını belirlemektir. Gereç ve Yöntem: Tüm hastaların (n=314) ilk kan serumunda alkalen fosfataz (ALP) ve alanin aminotransferaz (ALT) ölçülerek R değerleri belirlendi ve gruplandı. Daha sonra tespit edilen parametreler arasındaki korelasyonlar incelenerek ve farklılıklar cinsiyete göre analiz edildi. Ayrıca hastalar referans aralığın ALT ve ALP üst değerlerine göre karşılaştırıldı. Alfa değeri <0,05 olarak kabul edildi. Bulgular: Tüm hastalarda, ALT ve ALP normal referans aralıklarının oldukça üzerinde tespit edildi (p=0,000). R-değeri oranı, ALT ve ALP ile önemli ölçüde ilişkiliydi (p<0,001). R grupları istatistiksel olarak anlamlı ve yaşla ters orantılıydı (p=0,049). Kadınlarda ≥5 R oranının erkeklere göre daha yüksek olduğu tespit edildi. Sonuç: Bulgularımıza göre COVID-19 tanısı alan hastalarda ölçülen ALT ve ALP normalden çok daha yüksekti. Araştırmamızın bir başka ilginç sonucu da hastalarımızın çoğunda R-oranının ≤2 olarak bulunmasıydı. Akut karaciğer hasarının bir göstergesi olarak kabul edilen R≤2 bulgusu, COVID-19 için bu değerin izlenmesinin önemli bir gösterge olabileceğini düşündürmektedir.

Anahtar Kelimeler:

SARS-CoV-2, COVID-19, R-Oranı, ALT, ALP

COULD THE R-RATIO BE AN INDICATOR OF ACUTE LIVER INJURY FOR THE TREATMENT OF COVID-19?

Objective: The aim of the study was to determine whether the R-ratio could be an indicator in COVID-19 patients. Material and Method: Alkaline phosphatase (ALP) and alanine aminotransferase (ALT) were measured in the first blood serum of all patients (n=314), and R-values were determined and grouped. Then, the correlations between the detected parameters were examined and the differences were analyzed by gender. Patients were compared according to the ALT and ALP upper values of the reference interval. Alpha value was accepted as <0.05. Results: In all patients, ALT and ALP were detected well above normal reference ranges (p=0.000). The R-value ratio was significantly associated with ALT and ALP (p<0.001). R-groups were statistically significant and inversely proportional to age (p=0.049). It was detected that the R-ratio of ≥5 was higher in women than in men. Conclusion: According to our findings, ALT and ALP measurements in patients diagnosed with COVID-19 were much higher than normal. Another interesting result of our research was that the R-ratio was found to be ≤2 in the majority of our patients. The R≤2 finding, which is accepted as an indicator of acute liver injury, suggested that tracking of this value for COVID-19 could be an important indicator.

Keywords:

SARS-CoV-2, COVID-19, R-Ratio, ALT, ALP,

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