Yasin KUTLU, İlkim Deniz TOPRAK, Yasemin GÖKDEN, Hasan ERUZUN, Yücel ARMAN, Şengül AYDIN YOLDEMİR, Zeki TOPRAK, Tufan TÜKEK

İNFLAMATUAR BARSAK HASTALIKLARI AKTİVASYONU İLE sTREM-1 ARASINDAKİ İLİŞKİ

Amaç: İnflamatuar barsak hastalıkları (İBS) tanısında henüz uygun bir biyobelirteç bulunmamıştır. Çalışmamızda STREM-1 molekülünün bir belirteç olarak, İBS tanısında ve hastalık aktivitesini belirlemede uygunluğunu belirlemeyi amaçladık. Gereç ve Yöntem: Toplam 47 ülseratif kolit ve 25 Crohn hastalığı tanılı vaka çalışmaya dahil edildi. Crohn hastalığı için aktiviteyi belirlemede Crohn Hastalığı Aktivite İndeksi (CDAI), ülseratif kolit için ise Truelove-Witts indeksi kullanıldı. Bulgular: Sağlıklı grupla kıyaslandığında, sTREM-1 molekülü, İBS hastalarında anlamlı derecede düşük saptandı. Ülseratif kolit, Crohn hastalığı ve sağlıklı grup arasında sTREM-1 molekülü kıyaslandığında ise fark istatiksel olarak anlamlıydı. Aktif ve remisyonda olan hastalarda sTREM-1 düzeylerinde önemli bir fark bulunmamıştır. sTREM-1 seviyeleri C-reaktif protein, nötrofil- lenfosit oranı ve hemoglobin düzeyleri ile negatif korelasyon gösterdi. Sonuç: sTREM-1 seviyeleri İBS’de sağlıklı bireylere göre daha düşüktür. İBS tanısı için yararlı olabilir. Ancak, İBS’de hastalık aktivitesinin belirlemede doğru bir belirteç gibi görünmemektedir ve bu hastalarda hastalığın aktivitesini değerlendirmek için önerilemez.

Anahtar Kelimeler:

sTREM-1, inflamatuar barsak hastalıkları, Crohn hastalığı, ülseratif kolit

THE RELATIONSHIP BETWEEN sTREM-1 AND ACTIVATION OF INFLAMMATORY BOWEL DISEASES

Objective: In inflammatory bowel disease (IBD), there is no reliable biomarker, yet. We aimed to determine whether Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) could be useful as a marker for the diagnosis and/or the determination of disease activity in patients with IBD. Material and Method: A total of 47 patients with ulcerative colitis (UC) and 25 patients with Crohn’s disease (CD) were prospectively enrolled. Clinical disease activity was analyzed using the Crohn’s Disease Activity Index (CDAI) for CD and the Truelove- Witts index for UC. Results: sTREM-1 levels were significantly lower in patients with IBD compared to healthy controls (p=0.001). In comparison of the levels of sTREM-1 between the different groups (CD, UC, and healthy controls) the difference was statistically significant. No considerable differences in sTREM-1 levels were determined in patients with active versus quiescent disease. The sTREM-1 levels negatively correlated with C-reactive protein, blood neutrophil- lymphocyte ratio, and positively with haemoglobin levels. Conclusion: sTREM-1 levels are decreased in IBD patients compared with the healthy individuals. It may, therefore, be useful for the diagnosis of IBD. However, it does not seem to be a precise marker of disease activity in IBD and cannot be suggested for assessing disease activity in these patients.

Keywords:

sTREM-1, inflammatory bowel diseases, Crohn’s disease, ulcerative colitis,

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