___

• • Akar, F., Uludag, O., Aydin, A., Aytekin, Y. A., Elbeg, S., Tuzcu, M., & Sahin, K. (2012). High-fructose corn syrup causes vascular dysfunction associated with metabolic disturbance in rats: protective effect of resveratrol. Food and Chemical Toxicology, 50(6), 2135–2141.
• • Alsemeh, A. E., Samak, M. A., & El-Fatah, S. S. A. (2020). Therapeutic prospects of hydroxytyrosol on experimentally induced diabetic testicular damage: potential interplay with AMPK expression. Cell and Tissue Research, 380(1), 173–189.
• • Babacanoglu, C., Yildirim, N., Sadi, G., Pektas, M. B., & Akar, F. (2013). Resveratrol prevents high-fructose corn syrup-induced vascular insulin resistance and dysfunction in rats. Food and Chemical Toxicology, 60, 160–167.
• • Backhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005). Host-bacterial mutualism in the human intestine. Science, 307(5717), 1915–1920.
• • Balakumar, M., Raji, L., Prabhu, D., Sathishkumar, C., Prabu, P., Mohan, V., & Balasubramanyam, M. (2016). High-fructose diet is as detrimental as high-fat diet in the induction of insulin resistance and diabetes mediated by hepatic/pancreatic endoplasmic reticulum (ER) stress. Molecular and Cellular Biochemistry, 423(1-2), 93–104.
• • Bouhafs, L., Moudilou, E. N., Exbrayat, J. M., Lahouel, M., & Idoui, T. (2015). Protective effects of probiotic Lactobacillus plantarum BJ0021 on liver and kidney oxidative stress and apoptosis induced by endosulfan in pregnant rats. Renal Failure, 37(8), 1370–1378.
• • Brady, H. J. M., & Gil-Gomez, G. (1998). Molecules in focus - Bax. The pro-apoptotic Bcl-2 family member, Bax. International Journal of Biochemistry and Cell Biology, 30(6), 647–650.
• • Caldas, A. D., Porto, A. L., Motta, L. D., & Casulari, L. A. (2009). Relationship between insulin and hypogonadism in men with metabolic syndrome. Arquivos Brasileiros de Endocrinologia e Metabologia, 53(8), 1005–1011.
• • Chaki, S. P., Misro, M. M., Gautam, D. K., Kaushik, M., Ghosh, D., & Chainy, G. B. (2006). Estradiol treatment induces testicular oxidative stress and germ cell apoptosis in rats. Apoptosis, 11(8), 1427– 1437.
• • Choi, Y., Abdelmegeed, M. A., & Song, B. J. (2017). Diet high in fructose promotes liver steatosis and hepatocyte apoptosis in C57BL/6J female mice: Role of disturbed lipid homeostasis and increased oxidative stress. Food and Chemical Toxicology, 103, 111–121.
• • Cory, S., Huang, D. C., & Adams, J. M. (2003). The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene, 22(53), 8590–8607.
• • Coussens, M., Maresh, J. G., Yanagimachi, R., Maeda, G., & Allsopp, R. (2008). Sirt1 deficiency attenuates spermatogenesis and germ cell function. PLoS One, 3(2), e1571.
• • Cregan, S. P., Dawson, V. L., & Slack, R. S. (2004). Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene, 23(16), 2785–2796.
• • Dandona, P., & Dhindsa, S. (2011). Update: Hypogonadotropic hypogonadism in type 2 diabetes and obesity. Journal of Clinical Endocrinology and Metabolism, 96(9), 2643–2651.
• • Dhindsa, S., Miller, M. G., McWhirter, C. L., Mager, D. E., Ghanim, H., Chaudhuri, A., & Dandona, P. (2010). Testosterone concentrations in diabetic and nondiabetic obese men. Diabetes Care, 33(6), 1186–1192.
• • Du, Z., Qiu, Z., Wang, Z., & Wang, X. (2018). The inhibitory effects of soybean isoflavones on testicular cell apoptosis in mice with type 2 diabetes. Experimental and Therapeutic Medicine, 15(1), 305–309.
• • Ebrahimi, F., Schuetz, P., Mueller, B., Urwyler, S. A., Donath, M. Y., & Christ-Crain, M. (2017). Effects of IL-1 [beta] on the hypothalamic-pituitary- gonadal axis in men with obesity and metabolic syndrome-A randomized, double-blind, placebo-controlled trial. Paper presented at the 19th European Congress of Endocrinology. Endocrine Abstracts (2017) 49 EP687.
• • Faid, I., Al-Hussaini, H., & Kilarkaje, N. (2015). Resveratrol alleviates diabetes-induced testicular dysfunction by inhibiting oxidative stress and c-Jun N-terminal kinase signaling in rats. Toxicology and Applied Pharmacology, 289(3), 482–494.
• • Girard, S. A., Bah, T. M., Kaloustian, S., Lada-Moldovan, L., Rondeau, I., Tompkins, T. A., . . . Rousseau, G. (2009). Lactobacillus helveticus and Bifidobacterium longum taken in combination reduce the apoptosis propensity in the limbic system after myocardial infarction in a rat model. British Journal of Nutrition, 102(10), 1420–1425.
• • Green, D. R., & Llambi, F. (2015). Cell Death Signaling. Cold Spring Harbor Perspectives in Biology, 7(12), a006080.
• • Hayashi, K., Kojima, R., & Ito, M. (2006). Strain differences in the diabetogenic activity of streptozotocin in mice. Biological and Pharmaceutical Bulletin, 29(6), 1110–1119.
• • Hendijani, F., & Akbari, V. (2018). Probiotic supplementation for management of cardiovascular risk factors in adults with type II diabetes: A systematic review and meta-analysis. Clinical Nutrition, 37(2), 532–541.
• • Honda, K., Moto, M., Uchida, N., He, F., & Hashizume, N. (2012). Antidiabetic effects of lactic acid bacteria in normal and type 2 diabetic mice. Journal of Clinical Biochemistry and Nutrition, 51(2), 96–101.
• • Hotel, A. C. P., & Cordoba, A. (2001). Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Prevention, 5(1), 1–10.
• • Hu, Q. H., Zhang, X., Pan, Y., Li, Y. C., & Kong, L. D. (2012). Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats. Biochemical Pharmacology, 84(1), 113–125.
• • Huang, L., Zhao, Z., Duan, C., Wang, C., Zhao, Y., Yang, G., . . . Li, S. (2019). Lactobacillus plantarum C88 protects against aflatoxin B 1-induced liver injury in mice via inhibition of NF-κB–mediated inflammatory responses and excessive apoptosis. BMC Microbiology, 19(1), 170.
• • Koh, P. O. (2007a). Streptozotocin-induced diabetes increases apoptosis through JNK phosphorylation and Bax activation in rat testes. Journal of Veterinary Medical Science, 69(9), 969–971.
• • Koh, P. O. (2007b). Streptozotocin-induced diabetes increases the interaction of Bad/Bcl-XL and decreases the binding of pBad/14- 3-3 in rat testis. Life Sciences, 81(13), 1079–1084.
• • Korkmaz, O. A., Sadi, G., Kocabas, A., Yildirim, O. G., Sumlu, E., Koca, H. B., . . . Akar, F. (2019a). Lactobacillus helveticus and Lactobacillus plantarum modulate renal antioxidant status in a rat model of fructose-induced metabolic syndrome. Archives of Biological Sciences, 71(2), 265–273.
• • Korkmaz, O. A., Sumlu, E., Koca, H. B., Pektas, M. B., Kocabas, A., Sadi, G., & Akar, F. (2019b). Effects of Lactobacillus Plantarum and Lactobacillus Helveticus on Renal Insulin Signaling, Inflammatory Markers, and Glucose Transporters in High-Fructose-Fed Rats. Medicina (Kaunas, Lithuania), 55(5), 207.
• • Kwon, J., Kim, B., Lee, C., Joung, H., Kim, B.-K., Choi, I. S., & Hyun, C.- K. (2020). Comprehensive amelioration of high-fat diet-induced metabolic dysfunctions through activation of the PGC-1α pathway by probiotics treatment in mice. PLoS One, 15(2), e0228932.
• • Ley, R. E., Backhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005). Obesity alters gut microbial ecology. Proceedings of the National Academy of Sciences of the United States of America, 102(31), 11070–11075.
• • Liu, H., Zhang, S., Liu, C., Wu, J., Wang, Y., Yuan, L., . . . Zhuang, D. (2018). Resveratrol ameliorates microcystin-LR-induced testis germ cell apoptosis in rats via SIRT1 signaling pathway activation. Toxins, 10(6), 235.
• • Liu, Q., Liu, Y., Li, F., Gu, Z., Liu, M., Shao, T., . . . Feng, W. (2020). Probiotic culture supernatant improves metabolic function through FGF21-adiponectin pathway in mice. The Journal of Nutritional Biochemistry, 75, 108256.
• • Lowry, O. H., Rosebrough, N. J., Farr, A. L., & Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193(1), 265–275.
• • Lu, X. L., Zhao, C. H., Yao, X. L., & Zhang, H. (2017). Quercetin attenuates high fructose feeding-induced atherosclerosis by suppressing inflammation and apoptosis via ROS-regulated PI3K/AKT signaling pathway. Biomedicine and Pharmacotherapy, 85, 658–671.
• • Markowiak, P., & Slizewska, K. (2017). Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients, 9(9), 1021.
• • McBurney, M. W., Yang, X., Jardine, K., Hixon, M., Boekelheide, K., Webb, J. R., . . . Lemieux, M. (2003). The mammalian SIR2α protein has a role in embryogenesis and gametogenesis. Molecular and cellular biology, 23(1), 38–54.
• • Meydanli, E. G., Gumusel, A., Ozkan, S., Tanriverdi, G., Balci, M. B. C., Develi Is, S., . . . Bekpinar, S. (2018). Effects of resveratrol on highfructose- induced testis injury in rats. Ultrastructural Pathology, 42(1), 65–73.
• • Mohammadi, G., Dargahi, L., Naserpour, T., Mirzanejad, Y., Alizadeh, S. A., Peymani, A., & Nassiri-Asl, M. (2019). Probiotic mixture of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 attenuates hippocampal apoptosis induced by lipopolysaccharide in rats. International Microbiology, 22(3), 317–323.
• • Morrison, C. D., & Brannigan, R. E. (2015). Metabolic syndrome and infertility in men. Best Practice & Research: Clinical Obstetrics & Gynaecology, 29(4), 507–515. • Nna, V. U., Bakar, A. B. A., Ahmad, A., & Mohamed, M. (2018). Diabetes- induced testicular oxidative stress, inflammation, and caspase-dependent apoptosis: the protective role of metformin. Archives of Physiology and Biochemistry, 1–12.
• • Park, D. Y., Ahn, Y. T., Huh, C. S., McGregor, R. A., & Choi, M. S. (2013). Dual probiotic strains suppress high fructose-induced metabolic syndrome. World Journal of Gastroenterology, 19(2), 274–283.
• • Passos, J. F., Saretzki, G., Ahmed, S., Nelson, G., Richter, T., Peters, H., . . . von Zglinicki, T. (2007). Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biology, 5(5), e110.
• • Pektas, M. B., Koca, H. B., Sadi, G., & Akar, F. (2016). Dietary Fructose Activates Insulin Signaling and Inflammation in Adipose Tissue: Modulatory Role of Resveratrol. BioMed Research International, 2016, 8014252.
• • Pektas, M. B., Sadi, G., & Akar, F. (2015). Long-Term Dietary Fructose Causes Gender-Different Metabolic and Vascular Dysfunction in Rats: Modulatory Effects of Resveratrol. Cellular Physiology and Biochemistry, 37(4), 1407–1420.
• • Pektas, M. B., Yucel, G., Koca, H. B., Sadi, G., Yildirim, O. G., Ozturk, G., & Akar, F. (2017). Dietary Fructose-Induced Hepatic Injury in Male and Female Rats: Influence of Resveratrol. Drug Research (Stuttg), 67(2), 103–110.
• • Plaza-Diaz, J., Ruiz-Ojeda, F. J., Vilchez-Padial, L. M., & Gil, A. (2017). Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases. Nutrients, 9(6), 555.
• • Rastrelli, G., Filippi, S., Sforza, A., Maggi, M., & Corona, G. (2018). Metabolic syndrome in male hypogonadism. In Metabolic Syndrome Consequent to Endocrine Disorders (Vol. 49, pp. 131–155): Karger Publishers.
• • Rosa, D. D., Grzeskowiak, L. M., Ferreira, C. L., Fonseca, A. C., Reis, S. A., Dias, M. M., . . . Peluzio Mdo, C. (2016). Kefir reduces insulin resistance and inflammatory cytokine expression in an animal model of metabolic syndrome. Food & Function, 7(8), 3390–3401.
• • Sadi, G., Ergin, V., Yilmaz, G., Pektas, M. B., Yildirim, O. G., Menevse, A., & Akar, F. (2015). High-fructose corn syrup-induced hepatic dysfunction in rats: improving effect of resveratrol. European Journal of Nutrition, 54(6), 895–904.
• • Shahin, S., Singh, S. P., & Chaturvedi, C. M. (2018). 2.45 GHz microwave radiation induced oxidative and nitrosative stress mediated testicular apoptosis: Involvement of a p53 dependent bax-caspase- 3 mediated pathway. Environmental Toxicology, 33(9), 931–945.
• • Simoes, V. L., Alves, M. G., Martins, A. D., Dias, T. R., Rato, L., Socorro, S., & Oliveira, P. F. (2013). Regulation of apoptotic signaling pathways by 5alpha-dihydrotestosterone and 17beta-estradiol in immature rat Sertoli cells. Journal of Steroid Biochemistry and Molecular Biology, 135, 15–23.
• • Song, L., Chen, T. Y., Zhao, X. J., Xu, Q., Jiao, R. Q., Li, J. M., & Kong, L. D. (2019). Pterostilbene prevents hepatocyte epithelial-mesenchymal transition in fructose-induced liver fibrosis through suppressing miR-34a/Sirt1/p53 and TGF-β1/Smads signalling. British journal of pharmacology, 176(11), 1619–1634.
• • Song, W., Liu, M. G., Zhang, J. B., Zhang, J. J., Sun, M. M., & Yu, Q. K. (2016). Mechanism of action of EBV, Bcl-2, p53, c-Myc and Rb in non-Hodgkin’s lymphoma. European Review for Medical and Pharmacological Sciences, 20(6), 1093–1097.
• • Sumlu, E., Bostanci, A., Sadi, G., Alcigir, M. E., & Akar, F. (2020). Lactobacillus plantarum improves lipogenesis and IRS-1/AKT/eNOS signalling pathway in the liver of high-fructose-fed rats. Archives of Physiology and Biochemistry, 1–9.
• • Tsai, E. C., Matsumoto, A. M., Fujimoto, W. Y., & Boyko, E. J. (2004). Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat. Diabetes Care, 27(4), 861–868.
• • Tsounapi, P., Saito, M., Dimitriadis, F., Koukos, S., Shimizu, S., Satoh, K., . . . Sofikitis, N. (2012). Antioxidant treatment with edaravone or taurine ameliorates diabetes-induced testicular dysfunction in the rat. Molecular and Cellular Biochemistry, 369(1-2), 195–204.
• • Vachharajani, V. T., Liu, T., Wang, X., Hoth, J. J., Yoza, B. K., & McCall, C. E. (2016). Sirtuins link inflammation and metabolism. Journal of Immunology Research, 8167273.
• • Wang, H. F., Tseng, C. Y., Chang, M. H., Lin, J. A., Tsai, F. J., Tsai, C. H., . . . Tsai, C. C. (2012). Anti-inflammatory effects of probiotic Lactobacillus paracasi on ventricles of BALB/C mice treated with ovalbumin. Chinese Journal of Physiology, 55(1), 37–46.
• • Wang, X.-l., Wu, L.-y., Zhao, L., Sun, L.-n., Liu, H.-y., Liu, G., & Guan, G.-j. (2016). SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis. Biomedicine & Pharmacotherapy, 83, 41–50.
• • Wang, Y., Wu, Y., Wang, Y., Xu, H., Mei, X., Yu, D., . . . Li, W. (2017). Antioxidant Properties of Probiotic Bacteria. Nutrients, 9(5), 521.
• • Xu, Y., Lei, H., Guan, R., Gao, Z., Li, H., Wang, L., . . . Xin, Z. (2014). Studies on the mechanism of testicular dysfunction in the early stage of a streptozotocin induced diabetic rat model. Biochemical and Biophysical Research Communications, 450(1), 87–92.
• • Yadav, H., Jain, S., & Sinha, P. R. (2007). Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats. Nutrition, 23(1), 62–68.
• • Yildirim, O. G., Sumlu, E., Aslan, E., Koca, H. B., Pektas, M. B., Sadi, G., & Akar, F. (2019). High-fructose in drinking water initiates activation of inflammatory cytokines and testicular degeneration in rat. Toxicology Mechanisms and Methods, 29(3), 224–232.
• • Zhao, L., Gu, Q., Xiang, L., Dong, X., Li, H., Ni, J., . . . Chen, G. (2017). Curcumin inhibits apoptosis by modulating Bax/Bcl-2 expression and alleviates oxidative stress in testes of streptozotocin-induced diabetic rats. Therapeutics and Clinical Risk Management, 13, 1099– 1105.
• • Zhao, Y., Tan, Y., Dai, J., Li, B., Guo, L., Cui, J., . . . Cai, L. (2011). Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice. Toxicology Letters, 200(1-2), 100–106.
• • Zhao, Y., Tan, Y., Dai, J., Wang, B., Li, B., Guo, L., . . . Cai, L. (2012). Zinc deficiency exacerbates diabetic down-regulation of Akt expression and function in the testis: essential roles of PTEN, PTP1B and TRB3. Journal of Nutritional Biochemistry, 23(8), 1018–1026.