OCHRATOXIN A CONTAMINATION IN VINEGAR

OCHRATOXIN A CONTAMINATION IN VINEGAR

Ochratoxin A (OTA) is a mycotoxin that is often produced by mold species such as Aspergillus ochraceus, A. carbonarius, A. niger and Penicillium verrucosum. Ochratoxin-producing molds widely grow up and form toxins in raisins, figs, coffee beans and grains. In this study, the presence of OTA in home-made vinegars was examined with high performance liquid chromatography (HPLC). 88% of vinegar samples were OTA negative. In one of the samples examined, the amount of OTA is above 2 μg/L, which is the limit value. OTA is a mycotoxin with nephrotoxic properties. OTA, which enters the body, is absorbed from the intestines and enters the blood and accumulates by transporting blood to tissues and organs. The organ most affected by OTA is the kidneys, which may lead to a kidney disease called nephropathy. The results obtained in this study showed that there was a low amount of OTA in vinegars made at home. Since the presence of OTA in vinegar may pose a health risk, the necessary precautions should be taken by examining the factors affecting the formation of OTA.

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  • [1] Frisvad, J. C., Thrane, U., Samson, R. A., & Pitt, J. I. (2006). Important mycotoxins and the fungi which produce them. In Advances in food mycology (pp. 3-31). Springer, Boston, MA.
  • [2] Heperkan, D. (2014). Okratoksin A. Gıdalarda mikotoksinler. Heperkan, D. (Ed) 67-94. İzmir. Sidas Medya Ltd. Şti. Pp. 168.
  • [3] Pfohl-Leszkowicz, A., Petkova-Bocharova, T., Chernozemsky, I. N., & Castegnaro, M. (2002). Balkan endemic nephropathy and associated urinary tract tumours: a review on aetiological causes and the potential role of mycotoxins. Food additives & contaminants, 19(3), 282-302.
  • [4] Jadot, I., Decleves, A.-E., Nortier, J., & Caron, N. (2017). An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature. International Journal of Molecular Sciences, 18(2), 297.
  • [5] IARC (International Agency for Research on Cancer). (1993). IARC monographs on the evaluation of carcinogenic risks to humans. Some natural occurring substances: Food items and constituents, heterocyclic aromatic amines and mycotoxin. Lyon: 56:489-521.
  • [6] Munoz, K., Blaszkewicz, M., Campos, V., Vega, M., & Degen, G. H. (2014). Exposure of infants to ochratoxin A with breast milk. Archives of toxicology, 88(3), 837-846.
  • [7] Munoz, K., Cramer, B., Dopstadt, J., Humpf, H.U., & Degen, G. H. (2016). Evidence of ochratoxin A conjugates in urine samples from infants and adults. Mycotoxin Research, 33(1), 39–47.
  • [8] Piacentini, K. C., Ferranti, L. S., Pinheiro, M., Bertozzi, B. G., & Rocha, L. O. (2019). Mycotoxin contamination in cereal-based baby foods. Current Opinion in Food Science, 30, 73-78.
  • [9] Heperkan, D., Güler, F. K., & Oktay, H. I. (2012). Mycoflora and natural occurrence of aflatoxin, cyclopiazonic acid, fumonisin and ochratoxin A in dried figs. Food Additives & Contaminants: Part A, 29(2), 277-286.
  • [10] Khaneghah, A. M., Fakhri, Y., Abdi, L., Coppa, C. F. S. C., Franco, L. T., & de Oliveira, C. A. F. (2019). The concentration and prevalence of ochratoxin A in coffee and coffee-based products: A global systematic review, meta-analysis and meta-regression. Fungal biology, 123(8), 611-617.
  • [11] Eltem R., Aksoy, U., Altındisli A., Sarigul, N., Taskin, E., Askun, T., Ates, M., Meyvaci, B., Arasiler, Z., Turgut, H. & Kartal, N. (2003). Determination of OTA formation in seedless raisins in Aegean Region. National Mycotoxin Symposium Proceeding. Heperkan, D., Dalkilic, G, Senyuva, H. (Eds). 18-19 September, Istanbul. 23-45.
  • [12] Perrone, G., De Girolamo, A., Sarigiannis, Y., Haidukowski, M. E., & Visconti, A. (2013). Occurrence of ochratoxin A, fumonisin B2 and black aspergilli in raisins from Western Greece regions in relation to environmental and geographical factors. Food Additives & Contaminants: Part A, 30(7), 1339-1347.
  • [13] Stefanaki, I., Foufa, E., Tsatsou-Dritsa, A., & Dais, P. (2003). Ochratoxin A concentrations in Greek domestic wines and dried vine fruits. Food Additives & Contaminants, 20(1), 74-83.
  • [14] Domijan, A. M., & Peraica, M. (2005). Ochratoxin A in wine. Archiv za Higijenu Rada I Toksikologiju/Archives of Industrial Hygiene and Toxicology, 56(1), 17-20.
  • [15] Var, I., & Kabak, B. (2007). Occurrence of ochratoxin A in Turkish wines. Microchemical Journal, 86(2), 241–247.
  • [16] Turkish Food Codex Notification of Contaminants (2011). 2.2.6 Wine and fruit wines” Maximum limits in wine and fruit wine. p.3.