Mehmet TOPUZ, Burak DİKİCİ, Mehmet GAVGALI, Hakan YILMAZER

3D BIYO-YAZICILARDA KULLANILAN HİDROJELLER ÜZERİNE BİR İNCELEME

Biyo-yazıcı işlemi, farklı tıbbi alanlarda (doku mühendisliği, rejeneratif tıp veya diğer biyolojik çalışmalar) tıbbi yapıları imal etmek için hücreler ve biyomateryaller gibi biyolojik yapıların üretilmesi için bilgisayar destekli bir transfer işlemi olarak tanımlanmaktadır. Üç boyutlu (3D) bio-yazıcı teknolojisi, özellikle karaciğer, böbrekler, akciğerler ile vücuttaki diğer canlı organlar ile diğer organların yazdırılmasında kullanılır. Hidrojeller, yüksek biyo-uyumlulukları nedeniyle doku mühendisliği için hücre yüklemek için 3D biyo-yazıcıda yaygın olarak kullanılmaktadır. Buna ek olarak, hidrojeller vücutta bulunan yumuşak dokuları simüle etmesi, suda yüksek oranda şişebilme kaabiliyeti ve doğal yumuşak dokularınki ile benzer mekanik özelliklere sahip olmasından dolayı birçok araştırmacı hidrojel ile ilgilenmiştir ve onlara olan ilgi her geçen gün artmaktadır. Genellikle (i) doğal hidrojeller ve (ii) sentetik hidrojel olarak iki gruba ayrılırlar. Bu çalışmada hem doğal hem de sentetik hidrojeller hakkında literatürdeki önemli belgeler derlenmiş olup ek olarak, hidrojellerin 3D biyo-yazıcı işlemi detaylı bir şekilde tartışılmıştır.

Anahtar Kelimeler:

3D Yazıcı, Bio-yazıcı, Hidrojeller

A REVIEW ON THE HYDROGELS USED IN 3D BIO-PRINTING

The bio-printing process describes as a computer-aided transfer process for printing of biological structures such as cells and biomaterials to fabricate medical constructions for different medical fields (tissue engineering, regenerative medicine, or other biological studies). Especially, three-dimension (3D) bio-printing technology is used to print living organs like livers, kidneys, lungs, and any other organs in the body. Hydrogels have been widely used in 3D bio-printing to load cell for tissue engineering due to their high biocompatibility. In addition, hydrogels simulate the soft tissues which present in the body, swollen in water at high levels and have similar mechanical properties to those of natural soft tissues, many researchers have been interested in hydrogels and their reputations are increasing day by day. They are generally divided into two groups as (i) natural hydrogels and (ii) synthetic hydrogels. Key documents in the literature about both natural and synthetic hydrogels have been reviewed in this study. Also, 3D bio-printing process of the hydrogels has been discussed as detailly.

Keywords:

3D Printer, Bio-printing, Hydrogels,

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