Cem KARAGÖZLÜ, Necati AKBULUT, Mine BAYARER

İnsan beslenmesinde kolostrumun önemi ve kullanım olanakları

Kolostrum doğumdan sonra ilk 24-36 saat boyunca dişi memeliler tarafından Üretilen ilk doğal gıdadır. Sadece protein, karbonhidratlar, yağ, vitamin ve mineraller gibi besinlerin kaynağı değil, aynı zamanda vücudun immun ve büyüme fonksiyonları için gerekli bazı biyolojik aktif molekülleri de içermektedir. Kolostrum dönüştürücü büyüme faktörleri ile insülin benzer büyüme faktOrü 1 ve 2'nin tek doğal kaynağıdır. Bu büyüme faktörlerinin kas ve kıkırdak onarımında önemli rolleri vardır.

The importance of colostrum in human nutrition and its usage possibilities

Colostrum is the first natural food produced by female mammals during the first 24-36h directly after giving birth. It is not only a source of nutrients such as proteins, carbohydrates, fat, vitamins and minerals, but also contains several biologically-active molecules which are essential to the body's immune and growth functions. Colostrum is the only natural source of two major growths a factors namely transforming growth factors and insulin-like growth factors 1 and 2. These growth factors have significant role in muscle and cartilage repair.

PDF

___

Abdel-Wahab, M., El-Shennawy, F., Agha, S., Ragab, E., Fathi, O., Sultan, A., Elghawalby, N. ve Ezzat, F. 1999. Evaluation of cell mediated immunity in advanced pancreatic carcinoma before and after treatment with interleukin-2 (IL-2). Hepatogastroenterology, 46 supplement 1, 1293-1296.
Adam R.C. 1960. Süt I. Ege Üniversitesi Ziraat Fakültesi Yayınlan, 42 sayfa.
Anonim. 1994. NHANES (National Health and Nutritional Examination Survey), 1988-1994. A publication of the Dep. of Health and Human Sevices, National Center for Health Statistics. Available Through National Technical Information Service; 703-605-6000.
Bennan F. 1999. Interleukin-10 and arthritis. Rheumatology (Oxford), 38(4), 293-297.
Bittzan .M., Gold, B.D., Philpott, D.J., Huesca, M., Sherman, P.M., Karen, H., Lissner, R., Lingwood, C.A. ve Karmali, A.M. 1998. Inhibition of H. pylori and H. mustelae binding to lipid receptors by bovine colostrum. J. Infect Dis., 177, 955-961.
Bogstedt A.K. Johansen K. ve Hatta H. 1996. Passive immunity against diarrhea. Acta Paediatr, 8, 125-128.
Buckey, J.D. 2002. Bovine Colostrum: Does it Improve Athletic Performance. Nutrittion, 18(9), 776-777.
Cantagrel, A., Navaux, F.„Loubet-Lescoulie, P., Nourhashemi, F., Enault, G., Abbal, M., Constantin, A., Laroche, M. ve Mazieres, B. 1999. Interleukin-1 beta, interleukin-1 receptor antagonist, Inter-leukin-4 and Interleukin-10 gne polymorphisms: relationship to occurrence and severity of rheumatoid arthritis. Arthritis Rheum., 42(6), 1093-1100.
Chen Y. Shunzhang Y, Li W. 1988. Artificial feeding and hospitalization in the first 18 months of life. Pediatrics, 81, 58-62.
Cohen S. ve Williamson G.M., 1991. Stress and infectious diseas in humans. Psychological Bulletin, 109, 5-24.
Danesch.J., Koreth, J., Youngmann, L., Collins R., Arnold, J.R., Balarajan, Y., McGee, J. ve Roskell,D. 1999. Is Helicobacter pylori a factorin coronary atherosclerosis? J. Clin. Microbiol., 37(5), 1651.
Davidson G.P., Daniels, E., Nunan, H., Moore, A.G., Whyte, P.B.D., Franklin, K., McCloud, P.I. ve Moore, D.J. 1989. Passive immunization of children with bovine colostrum containing antibodies to human rotavirus. Lancet, 23, 709-712.
Duff L.C. Faden, H., Wasielewski, R., Wolf, J. ve Krystofik, D. 1997. Exclusive breastfeeding protects against bacterial colonization and day care exposure to otitis media. Pediatrics, 100, (4):7.
Francis G.L. 1986. Purification and partial sequence analysis of insulin-like growth Factor 1 from bovine colostrum, Biochemical Journal, 233(1), 207-213.
Francis G.L., Upton, F.M., Ballard, F., McNeil, K.A. ve Wallace, J.C. 1988. Insulin-like growth Factors 1 and 2 in bovine colostrum, BiochemicalJournal, 251, 95-103.
Goyco P.G. ve Becekman R.C. 1990. Sudden infant death syndrome. Curr Prob Pediatr., 20, 299-346.
Handa Y., Saitoh T., Kawaguchi M. ve Misaka R., 1999. Helicobacter pylori infection and histological types of gastric cancer. Nippon Shokokiloyo Gakkai Zasshi, 96, 634-643.
Henderson, D.R. ve Mitchell, D. 2000 Colostrum. CNR Publications ISBN -9676514-0-9 Sedona, AZ, USA . pp54.
Huizinga, T.W., van der Linden, M.W., Deneys-Laporte, V. ve Breedvely, F.C. 1999. Interleukin-10 as an explanation for pregnancy-induced flare in systemic lupus erythematosus and remission in rheumatoid arthritis. Rheumatlogy (Oxford) 38(6): 496-498.
Kiecolt-Glaser, J.K. ve Glaser, R. 1991. Stress and immune system: Human studies. In: Tasman and Riba, MB (eds), Annual Review of Psychiatry, 11, 169-180.
Mitra, A.K., Mahalanabis, D., Ashraf, H., Uni-comb, L., Eeckels, R. ve Tzipori, S. 1995. Hyperimmune cow colostrum reduces diarrhea due to rotavirus: a double blind study, cotrolled clinical trial. Acta Paediatrica, 84, 996-1001.
Nitsch A. ve Nitsch F.P.I998. The clincal use of bovine colostrum. Journal of Orthomolecular Medicine, 13(2), 110-118. Nord, J., Ma, P., Di John, D., Tzipori, S. ve Tacket, CO. 1990. Treatment with bovine hyperimmune colostrum of cryptosporidial diarrhea in AIDS patiens. AIDS, 4(6), 581-584.
Pakkanen, R. ve Aalto, 1.1991. Growth factor and antimicrobial factors of bovine colostrum. Int. Dairy Journal., 7, 285-297.
Ritchie J. 1994. Update on the management of intestinal cryptosporidiosis in AIDS. Ann Pharmacother, 28, 767-779.
Rump, J.A., Arndt, R., Arnold, A., Bendick, C, Dichtelmüller, H.,Franke, M., Helm, E.B., Jager, H., Kampmann, B. ve Kolb, P. 1994. Treatment of diarrhea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum. The Clinical Investigator, 70(7) 588-594.
Sabin, A.B. 1962. Antipoliomylitic activity of human and bovine colostrum and milk. Pediatrics, 29, 105-115.
Sandholm, M. ve Honkanen-Buzalski, T. 1980. Colostral trypsin-inhibitor capacity in different animal species'. Acta Veterinaria Scandinavica, 20(4), 469-476.
Scariati, P.D., Grummer-Strawn, L.M. ve Beck Fein, S. 1997. A longitudinal analysis of infant morbidity and the extent of breastfeeding in the United States. Pediatrics, 99(6), 5.
Stewart, A.K., Lassam, N.J., Quirt, I.C., Bailey, D.J., Rotstein, L.E., Krajden, M., Dessureault, S., Gallinger, S., Cappe, D., Wan, Y., Addison, C.L., Moen, R.C., Gauldie, J. ve Graham F.L. 1999. Adeno-vector-mediated gene delivery of inter-Ieukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial. Gene Theory,.6(3), 350-363
Stolte, M. ve Meining A. 1998. Helicobacter pylori and gastric cancer. Oncologist, 3(2), 124-128.
Strachan, D.P., Carrington, D., Mendall, A.M., Ballam, L., Morris J., Butland, B.K., Sweetnam, P.M., Elwood, P.C. ve West, R.R. 1999. Relation of Chlamydia pneumoniae serology to mortality and incidence of ischaemic heart disease over 13 years in the caerphilly prospective heart disease study. British Medical Journal, 318(7190), 1035-1039.
Tacket, CO., Binion, S.B., Bostwick, E., Losonsky, G., Roy, M.J. ve Edelman, R. 1992. Efficacy of bovine milk immunoglobulin concentrate in preventing illness after Shigella flexner challenge. American J. Tropical Medical and Hygiene, 47,276-283.
Tokuyama, Y. ve Tokuyama, H.1993. Purification and identification of TGF-beta-2-relted growth factors in muscle development. Journal of Dairy Research, 60, 99 -109.
Ueda, Y., Yamagishi, H., Tanioka, Y., Fujiwara, H., Fuji, N., Itoh, T., Fujiki, H., Yoshimura, T. ve Oka T, 1999. Clinical application of adoptive immunotherapy and IL-2 for the treatment of advanced digestive tract cancer. Hepatogastroenterology, 46, 1247-1249.
Ungar, B.L.P., Ward, D.J., Fayer, R. ve Quinn C.A. 1990. Cessation of Crytosporidium-associated diarrhea in AIDS patient after treatment with hyperimmune-bovine colostrum. Gastroenterology, 98,486-489.
Uruakpa, F.O., Ismond, M.A.H. ve Akobundu, E.N.T. 2002. Colostrum and its benefits: a review. Nutrition Research, 22, 755-767.
Verhoef, CM., van Roon, J.A., Vianen, M.E., Lafeber, F.P. ve Bijlsma, J.W. 1999. The immune suppressive effect of dexamethasone in rheumatoid arthritis is accompanied by upregulation of interleukin 10 and by differential changes in interferon gamma and interleukin 4 production. Ann. Rheum. Diss., 58(1), 49-54.
Visseren FL; Erkelens DW..1999. Atherosclerosis as an infectious disease. Ned Tijdschr Geneeskd,, 143(6), 291-295.
Warny, M., Fatımi, A., Bostwick, E.F., Laine, C, Lebel, F., LaMont, J.T., Pothoulakis, C. ve Kelly, C.P. 1999. Bovine immunoglobulin concentrate-C/ortrW/m difficile retains C. difficile toxin neutralising activity after passage through the human stomach and small intestine. Gut, 44 (2), 212-217.
Wilder, R.L. ve Elenkov, I.J. 1999. Hormonal regulation of tumor necrosis factor-alpha, interleukin-12 and interleukin-10 production by activated macrophages. A disease-modifying echanism in rheumatoid arthritis and systemic lupus erythematosus. Ann. N Y Academy of Science, 876, 14-31
http://www.svmbiotics.com.(Erisim:Ekim 2004)