Kök Hücreler ve Veteriner Hekimlikte Kullanım Alanları

Kök hücreler kendilerini yenileme özelliğine sahip olup, özel koşullar altında farklı hücre tiplerine dönüşebilmektedir. Kök hücreler farklılaşma özelliklerine göre; totipotent kök hücreler, pluripotent kök hücreler ve multipotent kök hücreler olarak sınıflandırılırken, embriyonik ve embriyonik olmayan kök hücreler olmak üzere iki ana gruba ayrılmaktadır. Bu derlemede kök hücrelerin genel özellikleri ile kök hücre tiplerinden bahsedilerek veteriner hekimlikte kullanım alanları hakkında özlü bilgi verilmesi amaçlanmıştır.

THE STEM CELLS AND THEIR USAGE IN VETERINARY MEDICINE

Stem cells have the ability to regenerate themselves, and when they are induced appropriateoy, can differentiate to many specialized cell types in the body and laboratory environments. Stem cells are classified as totypotent stem cells, pluripotent stem cells and multipotent stem cells based on their differentiation characteristics. In addition, they are divided into two main groups as embryonic and non-embryonic stem cells. In this review, it is aimed to give concise information about veterinary application areas by mentioning the general characteristics and stem cell types of stem cells.

___

  • Bianco P, Cao X, Frenette PS, Mao JJ, Robey PG, Simmons PJ, Wang CY, 2013: The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine. Nature Medicine, 19(1), 35-42. Clevers H, 2015: What is an adult stem cell? Science, 350(6266), 1319-1320. Das J, Nath I, Kumardas R, Routray P, Behera SS, 2012: Autologous stem cell therapy to treat chronic ulcer in heifer- A case study. Veterinary World, 5(12), 771-774. Erol H, Arıcan M, 2008: Atlarda Tendinitisin Kök Hücre İle Sağaltımı I: Kök Hücre Nedir ve Niçin Önemlidir? Veteriner Hekimliğinde Kullanım Alanları Nedir. Veteriner Cerrahi Dergisi, 14(2), 26-31. Gattegno-Ho D, Argyle SA, Argyle DJ, 2012: Stem cells and veterinary medicine: Tools to understand diseases and enable tissue regeneration and drug discovery. The Veterinary Journal, 191, 19–27. Harman RJ, 2013: Stem cell therapy in veterinary dermatology. Veterinary Dermatology, 24, 90–124. Juopperi TA, 2012: Back to basics: Stem cells and veterinary medicine. The Veterinary Journal, 191, 139–140. Kalra K and Tomar P.C, 2014: Stem Cell: Basics, Classification and Applications. American Journal of Phytomedicine and Clinical Therapeutics, 2(7), 919-930. Karaşahin T, 2012: Review Articles Embriyonik Kök Hücreler. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 9(1), 65-71. Kisiday JD, Kopesky PV, Evans CH, Grodzinky AJ, Mcwraith CW, Frisbie DD, 2008: Evoluation of Adult Equine Bone Marrow-and Adipose-Derived Progenitor Cell Chondrogenesis in Hydrogel Cultures. Journal of Orthopaedic Research, 26, 322-331. Kruse C, Danner D, Rapoport H, 2008: Current Stem Cell Technology: Limitations and Realistic Expectations. Engineering in Life Sciences, 8(1), 13–18. Lisker R, 2003: Ethical and Legal Issues in Therapeutic Cloning and the Study of Stem Cells. Archives of Medical Researches, 34, 607–611. Marfe G, Giordano MM, Ranallı M, Cozzoli E, Distefano C, Malafoglia V, Polettini M, Gambacurta A, 2012: Blood Derived Stem Cells: An Ameliorative Therapy in Veterinary Ophthalmology. Journal of Cellular Physiology, 227, 1250–1256. Meyer JR, 2000: Human embryonic stem cells and respect for life. Journal of Medical Ethics, 26(3), 166-170. Perin EC, Geng YJ, Willerson JT, 2003: Adult Stem Cell Therapy in Perspective. Circulation, 107, 935-938. Prockop DJ, 1997: Marrow Stromal Cells As Stem Cells For Nonhematopoietic Tissues. Science, 276(5309), 71-74. Sağsöz H, Ketani MA, 2008: Kök Hücreler. Dicle Üniversitesi Veteriner Fakültesi Dergisi, 1(2), 29-33. Şahin F, Saydam G, Omay SB, 2005: Kök Hücre Plastisitesi ve Klinik Pratikte Kök Hücre Tedavisi. Türk Hematoloji – Onkoloji Dergisi, 15(1), 48-56. Şenkal İV, Akyüz Ü, Yalnız F, Çiftçi F, Yurtsever A, 2011: Mezenkimal kök hücrelerin ratlarda crohn hastalığı modelinde doku hasarı, enflamatuar ve antienflamatuar sitokinlere etkisi. İstanbul Tıp Fakültesi Dergisi, 74(4), 59-63. Şimşek Ö, 2012: Yetişkin Kök Hücrelerin Dünü ve Bugünü. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 7(3), 231-236. Thomson JA, Eldor JI, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM, 1998: Embryonic Stem Cell Lines Derived from Human Blastocysts. Science, 282(5391), 1145-1147. Thore CB, Sudheer S, Janke D, Jagodzinska J, Jung M, Adjaye J, 2008: The Origins of Human Embryonic Stem Cells: A Biological Conundrum. Cells Tissues Organs, 188, 9–22. Udehiya RK, Amarpal, Aital HP, Kinjaydekar P, Pawde AM, Singh R, Sharma GT, 2013: Comparison of autogenic and allogenic bone marrow derived mesenchymal stem cells for repair of segmental bone defects in rabbits. Research in Veterinary Science, 94, 743 752. Ural AU, 2006: Kök Hücreler. Türk Ortopedi ve Travmatoloji Birliği Derneği Dergisi, 5, 140-145. Webster RA, Blaber SP, Herbert BR, Wilkins MR and Vese G, 2012: The role of mesenchymal stem cells in veterinary therapeutics – a review. New Zealand Veterinary Journal, 60(5), 265–272. Yasuaki O, Yasuhide Y, Hiroe O, Mika T, Yoshihiro K, Mari S, Yoko K, Koji H, Shigeru S, Katsuhisa H, Shunsuke Y, Hajime O, 2010: Induction of pluripotent stem cells from human third molar mesenchymal stromal cells. Journal of Biological. Chemistry, 285, 29270-29278. Yılmaz O, Uçar M, 2006: Kök hücre çalışmaları ve terapötik klonlama. Hayvancılık Araştırma Dergisi, 16(1), 26–31.