Öznur ASLAN, Kutlay GÜRBULAK, Kazım GÜVENÇ, Yücel ÇAM, Berrin KOCAOĞLU GÜÇLÜ, Fatma UYANIK

Kısırlaştırılan Kedilerde Krom Pikolinatın Ağırlık Artışı, Morfometrik Ölçümler ile Kan Lipid ve Leptin Seviyelerine Etkisi

Çalışmanın amacı, kısırlaştırılmış kedilerde krom pikolinatın (CrPic) morfometrik parametreler, ağırlık artışı ile serum lipit ve leptin seviyeleri üzerine etkisinin belirlenmesidir. Kısırlaştırılıp, 2 ay adaptasyon süresini takiben çalışmaya dahil edilen 32 (22 dişi ve 10 erkek) adet, yaşları 1-5 arasında değişen ve ağırlık ortalaması 3021 ± 453 g olan kediler 4 gruba ayrıldı. Kontrol grubu olarak tutulan kediler (Kontrol I), günlük enerji gereksinimi (60 kcal ME/kg) hesaplanarak ticari kuru mama ile beslendi. Ad-libitum beslenen diğer gruptaki kedilere sırasıyla CrPic kapsülden 0 (Kontrol II), 200 ya da 600 µg Cr/gün, 16 hafta süreyle uygulandı. En fazla ağırlık artışının belirlendiği Kontrol II’de, deri kalınlığı, abdominal çevre ve leptin düzeyinde düşük oranda bir artış gözlenirken, vücut kitle indeksi (BMI) ve göğüs çevresindeki artış önemli bulundu (P<0.05). CrPic verilen gruplarda ise bu değişkenlerdeki azalma önemli değildi. Plazma leptin seviyesi ile vücut ağırlığı (r = 0.510, P<0.01) ve aterojenik indeks (AI) arasında pozitif korelasyon (r = 0.479, P<0.05) belirlenirken, Cr arasında negatif korelasyon (r = -0.445, P<0.05) belirlendi. Kontrol II’de trigliserit (TG), total kolesterol (TC), düşük dansiteli lipoprotein (LDL), LDL ve yüksek dansiteli lipoprotein (HDL) oranı ve AI değerleri en yüksek seviyede olmakla birlikte, gruplar arasında fark gözlenmedi. Krom ilavesinin de bu parametrelere önemli bir etkisinin olmadığı saptandı. Serum Cr ve total kolesterol düzeyleri arasında negatif ilişki belirlendi (r = -0.468, P<0.05). Sonuç olarak, kısırlaştırıldıktan sonra ad-libitum beslenen tüm gruplarda canlı ağırlık, BMI, deri altı yağ doku ve plazma leptin seviyesinde artış belirlenirken, krom ilavesinin bu parametrelere önemli bir etkisinin olmadığı belirlendi.

Anahtar Kelimeler:

Kedi, Krom, Morfometrik ölçüm, Leptin, Lipit

Effects of Chromium Picolinate on Weight Gain, Morphometric Measurements and, Blood Lipid and Leptin Levels in Gonadectomized Cats

The aim of this study was determined to the effects of chromium picolinate (CrPic) on morphometric measurements, weight gain, and serum lipid and leptin levels in gonadectomized cats. Thirty two (22 female, 10 male), aged 1-5 years, weighing 3021 ± 453 g, were evenly distributed into four groups following a two month adaptation period after gonadectomy. Cats in one group was kept as control (Control I) and fed commercial dry cat food at the amount providing the daily requirements of 60 kcal ME/kg body weight. Cats in the remaining groups fed ad-libitum and supplemented daily with either 0 (Control II), 200 or 600 µg Cr/day as CrPic capsules for 16 weeks. The most marked increase in weight gain was determined in Control II in which significant increase was observed in chest circumference and body mass index (BMI) (P<0.05) whereas slightly increased levels were reported in Skinfold thickness, abdominal circumference and leptin levels. On the other hand, in the CrPic groups (200 and 600 µg/day) the reported decrease in these variables were not significant. Positive correlations were found between weight gain and plasma leptin (r = 0.510, P<0.01) and leptin and atherogenik indeks (AI) (r = 0.479, P<0.05) while Cr negatively correlated with leptin (r = -0.445, P<0.05). Although differences between groups were not significant, the highest values were determined in Control II regarding triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL), LDL to high density lipoprotein (HDL) ratio and AI. It was determined that chromium supplementation did not have significant effect on these parameters. Negative relationship was determined between serum Cr and TC (r = -0.468, P<0.05). In conclusion, in all groups ad-libitum feeding after gonadectomy resulted to increased weight gain, BMI, subcutaneous fat deposition and plasma leptin level. There is no effect in these parameters of chromium supplementation.

Keywords:

Cat, Chromium, Morphometric measurements, Leptin, Lipid,

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