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Silikozis Tanılı Seramik İşçilerinde Kan Tiroid Hormon Düzeyinin Değerlendirilmesi

Amaç:Bu çalışmada silikozis tanılı seramik işçileriyle silika maruziyeti olup silikozis gelişmeyen seramik işçilerinin, tiroid hormon düzeylerini değerlendirmeyi amaçladık. Materyal ve metod:Seramik endüstrisinde çalışan ve muayene için Ankara Meslek Hastalıkları Hastanesine başvuran 134’ü kontrol 260 vaka dahil edildi. Vakalara ait laboratuvar verileri, radyolojik raporlar, demografik özellikler, sigara öyküsü ve detaylı iş anamnezi retrospektif olarak hasta dosyalarından taranıp kaydedildi. Bulgular:Çalışmaya 126 silikozis ve 134 kontrol vakası dahil edildi. Silikozisli grup yaş ortalaması 38.6±6.7, kontrol grubu yaş ortalaması 35.2 (±5.6) olarak tespit edildi. Silikozisli grubun çalışma süresi 12 yıl (1-25), kontrol grubunun çalışma süresi 9 yıl (2-32) olarak tespit edildi. Silikozisli grupta sigara kullanma süresi 10 yıl (0-30), kontrol grubunda ise 7 yıl (0-30) olarak tespit edildi. Her iki grupta yaş, çalışma süresi ve sigara kullanma süreleri arasında anlamlı farlılık tespit edildi, p değeri sırasıyla (p=0.001, p<0.001, p=0.018). Silikozisli grupta FEV1pred, FVCpred, ve FEV1/FVC oranları kontrol grubuna göre düşük bulundu fakat bu değerler istatistiki anlamlı farklı değildi. Silikozisli grupta sT3=2.99±0.33 pg/ml, sT4=0.88 (0.67-0.94), TSH=1.28 (0.15-6.24), sT3/sT4=3.51±0.51 değerleri kontrol grubundan daha düşük olarak tespit edildi. Silikozisli ve kontrol grubunda sT3 ve sT4 düzeyleri arasında anlamlı farklılık tespit edildi (p<0.001, p=0.045). Sonuç:Bu çalışma silikozisli vakalarda kontrol grubuna göre, tiroid hormon düzeyi düşüklüğünü gösteren ilk çalışma olma özelliğini taşımaktadır. Silikozis düşünülen vakaların rutin klinik tanı süreçlerinde olası tiroid hormon bozukluğu da düşünülmelidir.

Anahtar Kelimeler:

Silikozis, Seramik işçisi, Pnömokonyoz, Serbest T3, Serbest T4

Evaluation of Blood Thyroid Hormone Level in Ceramic Workers Diagnosed with Silicosis

Abstract Background: In this study, it was aimed to evaluate the thyroid hormone levels of ceramic workers with silicosis and ceramic workers without silicosis. Methods: 260 cases (134 controls) who were employed in the ceramic industry and who applied to Ankara Occupational and Enviromental Diseases Hospital to be examined were included in the study. Laboratory data, radiological reports, demographic characteristics, smoking history and detailed work history were retrospectively reviewed and recorded from patient files. Results: The mean age of the silicosis group was 38.6±6.7 years and the mean age of the control group was 35.2±5.6. The working period of silicosis group was 12 years (1-25) and the control group was 9 years (2-32). The duration of smoking in the silicosis group was 10 years (0-30) and in the control group 7 years (0-30). A significant difference was found between age, duration of study and duration of smoking in both groups, and p value was respectively (p=0.001, p <0.00, p=0.018). FEV1pred, FVCpred, and FEV1/FVC ratios were lower in the silicosis group compared to the control group but these values were not statistically different. In the silicosis group sT3=2.99±0.33 pg/ml, sT4=0.88 pg/ml (0.67-0.94), TSH=1.28 mcIU/ml (0.15-6.24), sT3/sT4=3.51±0.51 were found to be lower than the control group. A significant difference was found between sT3 and sT4 levels in silicosis and control groups (p<0.001, p=0.045). Conclusion: In this study, sT3 and sT4 were significantly lower in the patients with silicosis than in the control group. Possible thyroid hormone disorders should be considered in routine clinical diagnosis processes of patients with silicosis.

Keywords:

Silicosis, Pneumoconiosis, Free T3, Free T4,

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