Katyonik Boyanın Anyonik Hidrojel Üzerinde Adsorbsiyonu ve Antibakteriyel Özelliklerle İlaç Uygulamasında İkinci Kullanımı

Bu çalışmada, serbest radikal kopolimerizasyonu ile 2,3-epoksipropilmetakrilat ve 2-akrilamido-2-metil-1propansülfonik asit içeren yeni bir uyarana duyarlı p (EPMA-co-AMPS) hidrojeller hazırlandı. Elde edilen hidrojellerin şişme özelliklerinin yanında yüzey morfolojisi, kimyasal ve mekanik özellikleri SEM, FTIR ve TPA kullanılarak tamamen karakterize edilmiştir. İlk olarak, çevresel uygulamalarda sulu çözeltiden katyonik boyaların uzaklaştırılması için hidrojeller kullanılmıştır. Hidrojellerin adsorpsiyon izotermleri ve kinetikleri, sırasıyla Langmuir denklemi ve yalancı-ikinci mertebeden denklem ile iyi bir uyum içindedir. Ayrıca, p (EPMA-co-AMPS) hidrojellerin adsorpsiyon kapasitesi, halihazırda bildirilmiş olan diğer adsorbanlarla karşılaştırıldığında rekabet etmektedir. İkinci olarak, biyomedikal uygulamalarda kontrollü ilaç salımı çalışmaları için hidrojelin bir ilaç taşıyıcısı olarak kullanımı araştırılmıştır. Son olarak, ilaç-yüklü hidrojeller Gram‐pozitif bakterilere (Bacillus cereus) ve Gram‐negatif bakterilere (Salmonella typhimurium) karşı antibakteriyel aktiviteler için test edilmiş ve antibakteriyel aktivite göstermiştir. Bu çalışmadan elde edilen sonuçlar, hazırlanan hidrojelin çeşitli uygulamalar için umut verici materyaller olabileceğini göstermektedir.

Adsoption of Cationic Dye on Anionic Hydrogel and Its Second Use for Drug Delivery with Antibacterial Properties

In this work, a novel stimuli-responsive p(EPMA-co-AMPS) hydrogels containing 2,3-epoxypropylmethacrylate and 2-acrylamido-2-methyl-1-propanesulfonic acid were prepared through free radical copolymerization. In addition to the swelling properties of the obtained hydrogels, surface morphology, chemical and mechanical properties are fully characterized using SEM, FTIR and TPA. Firstly, resulted hydrogels were carried out for removal of cationic dyes from aqueous solution in environmental applications. The adsorption isotherms and kinetics of hydrogels were in good agreement with Langmuir equation and the pseudo-second-order equation, respectively. In addition, the adsorption capacity of p(EPMA-co-AMPS) hydrogels compete with other currently reported adsorbents. Secondly, the use of hydrogel for controlled drug release studies in biomedical applications has been investigated as a drug carrier. Finally, drug-loaded hydrogels were tested for antibacterial activities against Gram‐positive bacteria (Bacillus cereus) and Gram‐negative bacteria (Salmonella typhimurium) and demonstrated antibacterial activity. Results obtained from this study suggest that the resulted hydrogel could be promising materials for various applications.

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