Birol BAYTAN, Adalet Meral GÜNEŞ, Melike Sezgin EVİM, Selin YAKARIŞIK, Rahime TÜTEN

Artmış Vitamin B12 Düzeyi

Vitamin B12 vücutta bütün hücreler için gereklidir. Vitamin B12 düzeyinindüşüklüğü kadar yüksekliği de anlamlıdır. Özellikle hematolojik hastalıklarda,solid tümörlerde, otoimmün hastalıklarda, renal hastalıklarda ve enfeksiyonhastalıklarında yüksek serum kobalamin düzeyleri saptanmıştır ve bu yükseklikbazı hastalıklarda prognozla ilişkili bulunmuştur. Serum vitamin B12 yüksekliğidikkate alınmalı ve bu konuda daha fazla çalışma yapılmalıdır.

Elevated Vitamin B12 Levels

Vitamin B12 is essential to all cells in the body. Both high levels and low levels ofvitamin B12 are significant. High serum cobalamin (vitamin B12) levels are foundparticularly in hematological disorders, solid tumors, autoimmune diseases, renaldiseases and infectious diseases; and this elevation is associated with prognosisin some of these diseases. High levels of serum vitamin B12 should be taken intoconsideration and more studies should be performed on this issue.

PDF

___

1. Andres E, Serraj K, Zhu J, Vermorken AJ. The pathophysiology of elevated vitamin B12 in clinical practice. QJM 2013;106:505-15.
2. Fedosov SN. Metabolic signs of vitamin B12 deficiency in humans: computational model and its implications for diagnostics. Metabolism 2010;59:1124-38.
3. Özcan M, Selim Hematoloji Ulusal Tanı ve Tedavi Grubu. B12 Vitamin Eksikliği Tanı ve Tedavi Kılavuzu 2011;1:3-10.
4. Carmel R, Green R, Rosenblatt DS, Watkins D. Update on cobalamin, folate, and homocysteine. Hematology Am Soc Hematol Educ Program 2003:62-81.
5. Watkins D, Whitehead VM, Rosenblatt DS. Megaloblastic anemia. In Orkin SH, Nathan DG, Ginsburg D, Look AT, Fisher DE, Lux SE, Eds. Nathan and Oskis Hematology of infancy and chilhood. Saunders Elsevier, Philadelphia, 2009:467-520.
6. Quadros EV. Advances in the understanding of cobalamin assimilation and metabolism. Br J Haematol 2010;148:195-204.
7. Vlasveld LT, Bos GM, Ermens AA, Bakker JA, Lindemans J. Hyperhomocysteinemi and functional cobalamin deficiency due to granulocytosis-induced alterations in thecobalamin-binding protein. Haematologica 2006;91:394-6.
8. Gauchan D, Joshi N, Gill AS, Patel V, Debari VA, Guron G, et al. Does an elevated serum vitamin B(12) level mask actual vitamin B(12) deficiency in myeloproliferative disorders? Clin Lymphoma Myeloma Leuk 2012;12:269-73.
9. Chiche L, Jean R, Romain F, Roux F, Thomas G, Canavese S, et al. İmplications cliniques de la decouverte dune hypervitaminemie B12 en medecine interne. Rev Med interne 2008;29:187-94.
10. Faurschou M, Nielsen OJ, Jensen MK, Hasselbalch HC. High prevalence of hyperhomocysteinemia due to marginal deficiency of cobalamin or folate in chronic myeloproliferative disorders. Am J Hematol 2000;65:136-40.
11. Baker H, Leevy CB, DeAngelis B, Frank O, Baker ER. Cobalamin (vitamin B12) and holotranscobalamin changes in plasma and liver tissue in alcoholics with liver disease. J Am Coll Nutr 1998;17:235-8.
12. Fremont S, Champigneulle B, Gerard P, Felden F, Lambert D, Gueant JL, et al. Blood transcobalamin levels in malignanat hepatoma. Tumor Biol 1991;12:353-9.
13. Callaghan FM, Leishear K, Abhyankar S, Demner-Fushman D, McDonald CJ. High vitamin B12 levels are not associated with increased mortality risk for ICU patients after adjusting for liverfunction: a cohort study. ESPEN J 2014;9:76-83.
14. Arendt JF, Pedersen L, Nexo E, Sorensen HT. Elevated plasma vitamin B12 levels as a marker for cancer: a population-based cohort study. J Natl Cancer Inst 2013;105:1799-805.
15. Aleksic D, Djokic D, Golubicic I, Jakovljevic V, Djuric D. The importance of the blood levels of homocysteine, folic acid and vitamin B12 in children with malignant diseases. J Buon 2013;18:1019-25.
16. Collin SM, Metcalfe C, Refsum H, Lewis SJ, Zuccola L,Smith GD, at al. Circulating folate, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiol Biomarkers Prev 2010;19(6):1632-42.
17. Chiristensen PA, Bryskov J, Gimsing P, Petersen J. Vitamin B12 binding proteins (transcobalamin and haptocorrin) in serum and synovial fluid of patients with rheumatoid arthritis and traumatic synovitis. Scand J Rheumatol 1983;12:268-72.
18. Arnalich F, Zamorano AF, Benito-Urbina S, Gijon-Banos J, De Miguel E, Pena JM, et al. Increased apotranscobalamin II levels in rheumatoid arthritis. Br j Rheumatol 1990;29:171-3.
19. Kalyocu U, Buyukasik Y, Akdoğan A, Karadag O, Bilgen SA, Kiraz S, et al. Increased serum vitamin B12 levels are associated with adult-onset Stills disease with reactive macrophage activation syndrome. Joint Bone Spine 2010;77:131-4.
20. Beckett AG, Matthews DM, Vitamin B12 in diabetes mellitus. Clin Sci 1962;23:361-70.
21. Ebesunun MO, Obajobi EO. Elevated plasma homocysteine in type 2 diabetes mellitus: a risk factor for cardiovascular diseases. Pan Afr Med J 2012;12:48.
22. Areekul S, Churdchu K, Cheeramakara C, Wilairatana P, Charoenlarp P. Serum transcobalamin II levels in patients with malaria infection. Southeast sian J Trop Med Public Health 1995;26:46-50.
23. Cheeramakara C, Thanomsak W,Songmeang k, Nontprasert A, Sanghirun C, Suthisai N, et al. Elevation of serum transcobalamin II in patients with scrub typhus. Southeast Asian J Trop Med Public Health 2005;36:113-7.
24. Tang AM, Smit E. Selected vitamins in HIV infection: a review. AIDS Patient Care STDs 1998;12:263-73.
25. Malik ZA, Abadi J, Sansary J, Rosenberg M. Elevated levels of vitamin B12 and folate in in vertically infected children with HIV-1. AIDS 2009 28;23:403-7.