Esat NAMAL, Bülent AŞKAROĞLU, Betül YILDIZ, Özgül PAMUKÇU CERCİZ, Pelin ALTINOK SÜT

Kolon Kanserli Hastalarda Post-Operatif Adjuvan Kemoterapide Kapesitabinin Tolerabilitesi: Tek Merkezli Çalışma

X-ACT (Xeloda in Adjuvant Colon Cancer Therapy) Çalışması’na göre kapesitabin kolon kanserlerinde adjuvan kemoterapide standart bir tedavi haline gelmiş bulunmaktadır. Ancak, biz kendi pratiğimizde kapesitabinin daha sık yan etkisi bulunduğunu gözlemlemekteyiz. Çalışmamızda karşılaştığımız yan etki profilini sunarak kapesitabin kullanımının klinik pratikte farklı sonuçlarla karşımıza gelebileceğini göstermeyi hedefledik. Çalışmamızda, kolon kanserli 89 hastamızın küratif rezeksiyon sonrası kapesitabin ile postoperatif 8 siklus adjuvan kapesitabin kemoterapisi sırasında gelişen yan etkileri ve buna bağlı tedavi sonlandırılma gereksinimlerini retrospektif olarak inceledik. Çalışmaya alınan 89 hastanın 82’si tedavi sikluslarını tamamlamış olup 3'ü 6 siklus; 2’si ise 3 siklus sonunda tedaviyi bırakmışlardır. Başlangıç dozu her hasta tarafından tolere edilmiş ancak tüm hastalarda tedavi süresince doz azaltımına gidilmiştir. Çalışmamızda, kapesitabinin önerilen dozlarını toksisite nedeniyle hiçbir hastamızın tolere edemediği ortaya konmuştur. X-ACT Çalışması’nda kapesitabinin daha az yan etki ile ilişkilendirilmiş olmasına karşın bizler çalışmamızda bu durumun aksini gözlemlemiş bulunmaktayız.

Anahtar Kelimeler:

kapesitabin, kolon, kanser

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