Astım Süreci ile İlişkili Güncel Faktörler: Obezite ve Beslenme

Son yıllarda yapılan çalışmalarda, görülme sıklığı giderek artan bir solunum sistemi hastalığı olan astım; beslenme şeklindeki değişimler ve obezite ile sıkça ilişkilendirilmektedir. Astım ve obezite prevalansının paralel olarak artması bu ilişkiye bir gerekçe olarak gösterilmekte ve her iki hastalığa yönelik ortak çalışmalar yapılmaktadır. Obezitenin akciğer kapasitesini düşürmesi, soluk alışverişini zorlaştırması, sistemik ve lokal inflamasyona yol açması her iki hastalığın ortak yönü olduğu hipotezini de desteklemektedir. Günümüzde astım hastalığındaki bu hızlı artış ile bireylerin yaşam tarzındaki değişimlerle de sıkça ilişkilendirilmektedir. Astımla ilişkili olarak birçok diyet hipotezi ortaya atılmakta ve değişen diyet içeriği astıma neden olan en önemli çevresel faktörlerden biri olarak gösterilmektedir. Bu çalışmada yetişkin bireylerde beslenme şekli ve obezitenin astım üzerine etkisi incelenerek konuyla ilgili güncel sonuçların yansıtılması amaçlanmıştır.

Current Factors Related with Asthma Process: Obesity and Nutrition

In recent years studies have shown that asthma, a respiratory disease that is increasingly common, is related with nutritional changes and obesity. The parallel increase in the prevalence of asthma and obesity is one of the reasons for this association. The reduction of lung capacity, difficulty in inspitarion exchange, and systemic-local inflammation increase the number of studies for both diseases. Today, this rapid increase in asthma disease is often associated with changes in the lifestyle of individuals. Many dietary hypotheses are associated with asthma and varying dietary content is shown as one of the most important environmental factors causing asthma. In this study, effects of nutrition and obesity on asthmatic diseases in adult subjects were investigated and it was aimed to keep light on this subject. In this study it was aimed to reflect that the et of nutritional habits and obesity on asthma in adult subjects with current results.

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Rice, J. L., Romero, K. M., Davila, R. M. G., Meza, C. T., Bilderback, A., D’Ann, L. W. (2015). Association between adherence to the Mediterranean diet and asthma in Peruvian children. Lung, 193(6), 893-899.
Warstedt, K., Furuhjelm, C., Fälth‐Magnusson, K., Fagerås, M., & Duchén, K. (2016). High levels of omega‐3 fatty acids in milk from omega‐3 fatty acid‐supplemented mothers are related to less immunoglobulin E‐associated disease in infancy. Acta Paediatrica, 105(11), 1337-1347.
Yieh, L., Hoffmann, S. W., Caughey, A. B., McEvoy, C. T., Dukhovny, D. (2017). 577: Vitamin c supplementation for pregnant smokers to improve lung function at birth and reduce childhood asthma: a decision analysis. American Journal of Obstetrics & Gynecology, 216(1), S340.
Allan, K. M., Prabhu, N., Craig, L. C., McNeill, G., Kirby, B., McLay, J., Devereux, G. (2015). Maternal vitamin D and E intakes during pregnancy are associated with asthma in children. European Respiratory Journal, 45(4), 1027-1036.
Wood, LG., Shivappa, N., Berthon, BS., Gibson, PG., Hebert, JR. (2015). Dietary inflammatory index is related to asthma risk, lung function and systemic inflammation in asthma. Clinical & Experimental Allergy, 45: 177-183.
Zammit, C., Liddicoat, H., Moonsıe, I., Makker, H. (2010). Obesity and respiratory diseases. Int J Gen Med, 3: 335-343.
Göker, M., İlkhan, GD. (2014). Obezite Hipoventilasyon Sendromu. Okmeydanı tıp dergisi 30(Ek sayı 1):15-18.
Murugan, AT., Sharma, G. (2008). Obesity and respiratory diseases. Chron Respir Dis, 5(4): 233–242.
Salepci, BM., Fidan, A., Kıral, N., Parmaksız, E., Saraç, G., Cömert, SŞ., Çağlayan, B. (2012). Obstrüktif uyku apne sendromlu hastalarda koah ile astım sıklığı ve bu hastalıkların obstrüktif uyku apne sendromunun şiddeti ile uyku kalitesine etkisi. Solunum derg, 14: 141-147.
Yuksel, H., Sogut, A., Yilmaz, O., Onur, E., & Dinc, G. (2012). Role of adipokines and hormones of obesity in childhood asthma. Allergy, asthma & immunology research, 4(2), 98-103.
Miyake, Y., Sasaki, S., Tanaka, K., Ohfujı, S., & Hırota, Y. (2009). Maternal fat consumption during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: The Osaka Maternal and Child Health Study. Thorax, 64(9), 815-821.1.
Takemura, Y., Sakurai, Y., Honjo, S., Tokimatsu, A., Gibo, M., Hara, T., & Kugai, N. (2002). The relationship between fish intake and the prevalence of asthma: the Tokorozawa childhood asthma and pollinosis study. Preventive medicine, 34(2): 221-225.
Pu, S., Nakagome. K., Yamada, T., Matsumur, a H., Yokoyama, K., Kaneko, K., & Kurosawa, Y. (2015). Association between fish consumption and prefrontal function during a cognitive task in male Japanese workers: A multi-channel near-infrared spectroscopy study. Plos One, 10(4), 972.
Reisman, J. (2011). Commentary on ‘Dietary marine fatty acids (fish oil) for asthma in adults and children’. Evidence‐Based Child Health: A Cochrane Review Journal, 6(3), 1015-1016.
Chatzi, L., Torrent, M., Romieu, I., Garcia-Esteban, R., Ferrer, C., Vioque, J., & Sunyer, J. (2008). Mediterranean diet in pregnancy is protective for wheeze and atopy in childhood. Thorax, 63(6), 507-513.
Chatzi, L., Apostolaki, G., Bibakis, I., Skypala, I., BibakiLiakou, V., Tzanakis, N., & Cullinan, P. (2007). Protective effect of fruits, vegetables and the Mediterranean diet on asthma and allergies among children in Crete. Thorax, 62(8), 677-683.
Dunder, Tl., Kuikka, L., Turtinen, J., Räsänen, L., & Uhari, M. (2001). Diet, serum fatty acids, and atopic diseases in childhood. Allergy, 56(5), 425-428.
Mayser, P., Mayer, K., Mahloudjian, M., Benzing, S., Kramer, H.J., Schill, W.B., & Grimminger, F.A. (2002). Double-blind, randomized, placebo-controlled trial of n-3 versus n-6 fatty acid-based lipid infusion in atopic dermatitis. Journal of Parenteral and Enteral Nutrition, 26(3), 151-158.
Simopoulos, A.P. (2002). The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomedicine & pharmacotherapy, 56(8), 365-379.
Fogarty, A., Lewis, S., Weiss, S., & Britton J. (2000). Dietary vitamin E, IgE concentrations, and atopy. The Lancet, 356(9241),1573-1574.
Nurmatov, U., Devereux, G., & Sheikh, A. (2011). Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis. Journal of Allergy and Clinical Immunology, 127, 724-733.
Kalayci, O., Besler, T., Kilinc, K., Sekerel, B.E., & Saraclar, Y. (1999). Serum levels of antioxidant vitamins (alpha tocopherol, beta carotene, and ascorbic acid) in children with bronchial asthma. The Turkish Journal of Pediatrics, 42(1), 17-21.
Allen, S., Britton, J.R., & Leonardi-Bee, J.A. (2009). Association between antioxidant vitamins and asthma outcome measures: systematic review and meta-analysis. Thorax, 64 (7),610-619.
Trenca, C.A., Koenig, J.Q., & Williams, P.V. (2001). Dietary antioxidants and ozone-induced bronchial hyperresponsiveness in adults with asthma. An International Journal, 56, 242-249.
Anetor, J.I., Ajose, O.A., Ige, O., Oyeleye, A.O., & Ojo, P.O. (2003). Antioxidant status of adult Nigerian asthmatics: implications for prognosis. Nutrition and health,17(3), 221-229.
Tricon, S., Willers, S., Smit, H.A., Burney, P.G., Devereux, G., Frew, A.J., & Warner, J.O. (2006). Nutrition and allergic disease. Clinical & Experimental Allergy Reviews, 6(5), 117-188a.
Rubin, R.N., Navo, L. & Cassano, P.A. (2004). Relationship of serum antioxidants to asthma prevalence in youth. American journal of respiratory and critical care medicine, 169(3): 393- 398.
Luis, D.A., Armentia A., Aller R., Asensio A., Sedano E., Izaola O., & Cuellar, L. (2005). Dietary intake in patients with asthma: a case control study. Nutrition, 21(3), 320-324.
Burns, J.S., Dockery, D.W., Neas, L.M., Schwartz, J., Coull, B.A., & Raizenne, M. (2007). Low dietary nutrient intakes and respiratory health in adolescents. Chest, 132(1), 238-245.
Allan, K., & Devereux, G. (2011). Diet and asthma: nutrition implications from prevention to treatment. Journal of the American Dietetic Association, 111(2), 258-268.
Kern, P.A., Di Gregorio, G.B., & Lu, T. (2003). Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression. Diabetes, 52(7), 1779-85.
Sood, A., Cui, X., Qualls, C., Beckett, W.S., Gross, M.D., Steffes, M.W., & Jacobs, D.R. (2008). Association between asthma and serum adiponectin concentration in women. Thorax, 63(10), 877–882.
Shin, J.H., Kim, J.H., & Lee, W.Y. (2008). The expression of adiponectin receptors and the effects of adiponectin and leptin on airway smooth muscle cells. Yonsei Med J, 49(5), 804-10.
Martin-Romero C., Santos-Alvarez J., & Goberna R. (2000). Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol, 199(1), 15-24.
Jequier, E. (2002). Leptin signaling, adiposity, and energy balance. Ann N.Y Acad Sci, 967(1), 379-88.
Kershaw, E.E., & Flier, JS. (2004). Adipose tissue as an endocrine organ. J Clin Endocrinol Metab, 89(6), 2548-56.
Machefer, G., Groussard, C., Vincent, S., Zouhal, H., Faure, H., Cillard, & Gratas-Delamarche A. (2007). Multivitamin-mineral supplementation prevents lipid peroxidation during “the Marathon des Sables. Journal of the American College of Nutrition, 26(2), 111-120.
Bradding, P., Roberts, J.A., & Britten KM. (1994). Interleukin4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol, 10(5),471-80.
Maffeis, C., Silvagni D., & Bonadonna R. (2007). Fat cell size, insulin sensitiviy, and inflammation in obese children. J Pediatr, 151(6), 47-652.
Park, H.S., Park, J.Y., & Yu, R. (2005). Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNFalpha and IL- 6. Diabetes Res Clin Pract, 69(1), 29-35.
Visser, M., Bouter, L.M., & Mcquillan G.M. (2001). Lowgrade systemic inflammation in overweight children. Pediatrics, 107:13.
Fredberg, J.J., Inouye, D.S., Mijailovich S.M., & Butler J.P. (1999). Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm. Am J Respir Crit Care Med,159(3), 959–967.
Farah, C.S., & Salome, C.M. (2012). Asthma and obesity: a known association but unknown mechanism. Respirology, 17(3), 412-421.
Lopata, M., & Önal, E. (1982). Mass loading, sleep apnea and the pathogenesis of obesity hypoventilation. Am Rev Respir Dis, 126(4), 640-5.
Laaban, J.P., Orvoen-Frija, E., & Cassuto, D. (1996). Mecanismes de l’hypercapnie diurne dans le syndrome d’apnee du sommeil associe a une obesite massive. Presse Med, 25(1), 12-16.
Ford, E.S. (2005). The epidemiology of obesity and asthma. Journal of Allergy and Clinical Immunology , 115(5): 897-909.
Beuther, D.A., & Sutherland, E.R. (2007). Overweight, Obesity, and Incident Asthma: A Meta-analysis of Prospective Epidemiologic Studies. Am J Respir Crit Care Med, 175(7),661-6.
Tantisira, K.G., & Weiss, S.T. (2001). Complex interactions in complex traits: obesity and asthma. Thorax, 56: 64–73.
Jones, Rl., & Nzekwu, M.M.U. (2006). The effects of body mass index on lung volumes. Chest Journal, 130(3), 827-833.
Salome, C.M., King, G.G., & Berend, N. (2013). Effects of obesity on lung function. Respiratory medicine, 1: 1-5.
Rabec, C., De Lucas, R.P., & Veale, D. (2011). Respiratory complications of obesity. Arch Bronconeumol, 47(5): 252–261.
Behazin, N., Jones, S.B., & Cohen, R.I. (2010) Respiratory restriction and elevated pleural and esophageal pressures in morbid obesity. J. Appl. Physiol, 108(1), 212–18.
Hong, S.J., Lee, M.S., Lee, S.Y., Ahn, K.M., Oh, J.W., Kim, K.E., & Lee, H.B. (2006). High body mass index and dietary pattern are associated with childhood asthma. Pediatric pulmonology, 1(12), 1118-1124.
Altunkaynak, B.Z., & Özbek, E. (2006). Obezite: nedenleri ve tedavi seçenekleri. Van Tıp Dergisi, 13(4), 138-142.
Peng, H., Zhang, Q., Shen, H., Liu, Y., Cha, o X., Tian, H., & Jin, J. (2015). Association between serum soluble corin and obesity in Chinese adults: A cross‐sectional study. Obesity, 23(4), 856-861.
WHO (World Health Organization). 10 Facts on obesity. Erişim Adresi: [ http://www.who.int/features/factfiles/obesity/facts/en/ ]. Erişim Tarihi: 17/10/2016.
Barros, R., Moreira A., Padrão P., Teixeira VH., Carvalho P., Delgado L., & Moreira, P. (2015). Dietary patterns and asthma prevalence, incidence and control. Clinical & Experimental Allergy, 45(11),1673-1680.
Devereux, G., & Seaton A. (2005). Diet as a risk factor for atopy and asthma. Journal of Allergy and Clinical İmmunology, 115(6), 1109-1117.
Thomas, D.A. (2003). Study on the mineral depletion of the foods available to us as a nation over the period 1940 to 1991. Nutrition Health, 17: 85-115.
Lee, S.C., Yang, Y.H., Chuang, S.Y., Lia, S.C., Yang, H.C., & Pan, W.H. (2012). Risk of asthma associated with energy-dense but nutrient-poor pattern in Taiwanesse children. Asia Pac J Clin Nutr, 21(1): 73-81.
Sabuncular, C. (2013). 6-15 yaş grubu çocuklarda astım görülmesi ile Akdeniz tarzı beslenme durumu arasındaki ilişkinin değerlendirilmesi. Beslenme ve Diyetetik Anabilim Dalı, İstanbul, Yüksek Lisans Tezi.
WHO (World Health Organization). (2013). Health topics asthma. Erişim Adresi http://www.who.int/topics/asthma/en/. Erişim Tarihi: 17/10/2016.
Melikoğlu, G., Kurtoğlu, S., & Kültür, Ş. (2015). Türkiye'de Astım Tedavisinde Geleneksel Olarak Kullanılan Bitkiler. Marmara Pharmaceutical Journal, 19 (1), 20-24.