Mustafa BÜYÜKMUMCU, MUZAFFER ŞEKER, A. Kağan KARABULUT, Taner ZİYLAN, İSMİHAN İLKNUR UYSAL

İnsan fötuslarında damar gelişimlerinin mikrodiseksiyonla incelenmesi

Amaç: Bu çalışmada insan fötuslarının 2. ve 3. trimester süresince arcus aortae, Aorta thoracica, Aorta abdominalis ve dallarının gelişim ve morfolojisine yönelik normal morfometrik değerlerin elde edilmesi amaçlanmıştır. Yöntem: Gelişim yaşı CRL aracılığı ile belirlenen 60 abort insan fötusunda 2. ve 3. trimester'de büyük damarların büyüme ve gelişimleri incelendi. Fötuslar % 10 formalin içinde korundu. Her bir vakada rutin diseksiyon kuralları uygulandı. Kalınlık ölçümlerinde damarların dış çap ölçümleri esas alındı. Kalp ve büyük damarların ince diseksiyonundan sonra damarların kalınlık ve uzunluk ölçümleri kumpas aracılığı ile belirlenerek sonuçlar yaş ve cinsiyete göre değerlendirildi. Bulgular: 2. trimesterde aorta bölümlerine ait kalınlık ve uzunluk değerleri yönünden her iki cinsiyet arasında farklılık tespit edilemezken 3. trimesterde tüm parametrelerde farklılık belirlendi (P

Anahtar Kelimeler:

Koroner damarlar, Diseksiyon, Fetal kalp, Fetal organ olgunlaşması, Fetüs, Gebelik yaşı, Büyüme, Fetal gelişim, Kan damarları, Aort

The investigation of the vessels development in human fetuses by microdissection

Objective: The purpose of the present study was to establish normal values for aortic arch, thoracic aorta and abdominal aorta growth and morphology in the human fetus throughout the second and third trimesters. Methods: We studied the growth and development of the great vessels in the 60 human aborted fetuses (35 fetuses; 17male, 18 female in second trimester and 25 fetuses;10 male, 15 female in third trimester). Developmental age was determined by CRL. All of the fetuses preserved in 10% formalin. In each of the total 60 cases, a complete autopsy was performed. The diameter measurement of the vessels is external diameter. After the fine dissection of the heart and great vessels the subdivision of aorta was measured by a compass and their results analyzed statistically regarding the sex and age. Results: There was no statistically significant difference on the values of the subdivisions and branches of the aorta between the sexes in the second trimester. Statistically significant differences were determined in the third trimester regarding to the subdivisions and some of the branches of the aorta. Conclusions: The normal values of the developing aorta in human fetuses obtained in the present study and the ratios amongst them can be useful tool for determining the changes of the dimensions of the aorta in different gestational period which can also be used for the diagnosis of the congenital vascular diseases.

Keywords:

Coronary Vessels, Dissection, Fetal Heart, Fetal Organ Maturity, Fetus, Gestational Age, Growth, Fetal Development, Blood Vessels, Aorta,

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