Elit taekwondocularda c vitamini uygulamasının IFN-γ, TNF-α, IL-2 ve IL-6 düzeylerine etkisi

Amaç: Bu çalışmanın amacı, taekwondo sporu yapan bireylerde C vitamini uygulamasının sitokin salınımı üzerindeki etkilerinin araştırılmasıdır. Gereç ve Yöntem: Bu araştırma Selçuk Üniversitesi Beden Eğitimi ve Spor Yüksekokulunda okuyan yaş ortalaması; 20.67±0.24 yıl, vücut ağırlığı ortalaması; 65.45±1.69 kg olan 10 adet erkek elit taekwondocu üzerinde gerçekleştirildi. Deneklere 4 hafta süreyle günde oral olarak 300 mg C vitamini tablet şeklinde verildi ve 4 haftalık vitamin ilavesi öncesi ve sonrası olmak üzere iki kez yorgunluk oluşuncaya kadar tükenme egzersizi yaptırıldı. Dört hafta süren uygulama öncesinde ve sonrasında deneklerden istirahat ve yorgunluk olmak üzere 4 kez kan örnekleri alındı. Alınan kan örneklerinde serumda interferon gama (IFN-γ), tümör nekrosiz faktör-alfa (TNF-α), interlökin-2 (IL-2) ve interlökin-6 (IL-6) düzeyleri ELISA test kitleri kullanılarak tayin edildi. Bulgular: IFN-γ, TNF-α ve IL-2 düzeyleri hem uygulama öncesi hem de sonrası anlamlı bir farklılık göstermedi (p>0.05). Uygulamadan önceki egzersiz periyodunda serum IL-6 düzeylerinde dinlenme periyoduna göre anlamlı artış vardı (p

Objective: The aim of this study was to investigate the effects of vitamin C application on secretion of cytokine in individuals who do taekwondo sport. Materials and Methods: This research was carried out on 10 elite taekwondo athletes who were studying in Selçuk University, School of Physical Education and Sports. Their mean age; 20.67±0.24 years and mean body weight was; 65.45±1.69 kg. Every day 300 mg vitamin C was given to the participants orally during 4 weeks and exhaustive exercise was done until fatigue occurs before and after vitamin E treatment. Before and following the 4 week implementation period, blood samples were taken 4 times from the participants as at rest and fatigue. Interferon gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α), interleukin -2 (IL-2) and interleukin -6 (IL6) levels were determined by ELISA test kits on taken blood samples. Results: There were no significant differences on the levels of IFN-γ, IL-2 and TNF-α both before and after implementation. There was significant increase on the levels of serum IL-6 at exercise period in comparison with resting period (P

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