Fumarik asit, maleik asit ve bunların karışımlarının 2-propanol ortamında potansiyometrik titrasyon metoduyla tayini

Birbirlerinin cis-trans izomeri olan fumarik ve maleik asit ve bunların karışımları, 2-propanol ortamında, 25°C sabit sıcaklıkta ve azot atmosferinde, tetrabutil amonyum hidroksitle potansiyometrik olarak titre edildi. Titrasyon eğrilerinden karışım analizleri yapıldı ve sonuçlar %95 güven seviyesinde hesaplandı. Elde edilen sonuçlar ile, potansiyometrik susuz ortam titrasyonlarının, maleik asit, fumarik asit ve karışımlarının analizleri için uygun bir metot olduğu gösterildi.

Determination of fumaric acid and maleic acid and their mixtures in 2-propanol using potentiometric titration method

Various mixtures of fumaric and maleic acids, cis-trans izomers of each other, were prepared in 2-propanol and potentiometrically titrated using tetrabuthyl ammonium hydroxide, under nitrogen atmosphere and 25°C constant temperature. Mixture analyses were performed from the titration curves and the results presented in 95% confidence level. Illustrated that the method was reliably applicable for the analysis the above mixture.

___

(1)Hawley, G. G., The Condensed Chemical Dictionary, Tenth Edition, by Van Nostrand Reinhold Com. Inc., 481-482, 638., 1981
(2)Tüzün, C, Organik Kimya, Okan Yayın Dağıtım, Ankara, 298-300, 1988
(3)Kirk-Othmer., Encyclopedia of the Technology, 680-696, 1952
(4)Skoog, D. A., West, D. M., Holler, F. J., Analitik Kimya Temelleri 1., Kılıç. E., Köseoğlu F., Bilim Yayıncılık, Ankara, 48-50, Ek 3, 1999
(5)Gündüz, T., Susuz Ortam Reaksiyonları, Gazi Kitabevi, Ankara, 24-25, 1998
(6)Meurs, N. V and Dahmen, A. M. F., "The conductometric titration of carboxylic and phenolic acids in non-aqueous solutions I. Preliminary experiment", I Analitica Chimica Acta, 19,64-73, 1958
(7)Meurs, N. V and Dahmen, A. M. F., "The conductometric titration of carboxylic and phenolic acids in non-aqueous solutions, II. Study of the titration of dibasic acids", Analitica Chimica Acta, 21, 10-16,1959
(8)Dietz, E. A., Singley, K. F., "Determination of fumaric acid, maleic acid, and phthalic acid in brcundwater and soil", Journal of Liquid Chromatography, 17, 1637-1651, 1994
(9)Liu, A. H., Wang, E. K., "Determination of catechol derivaties on pretreatment and copolymer coated glassy-carbon eletode", Talanta, 41, 147-154,1994
(10)Szczepaniak, W., Ren, M., "Determination of trace amounts of impurities in Pharmaceutical preparations by differantial-pulse polarografi, 1. Determination of diisooctyl maleate in the pharmaceutical sodium 1, 4- bis(2-ethylhexyl) sulphosuccinate and of maleic acid in fumaric acid", Analytica Chimica Acta, 273, 335-338, 1993
(11)Craston, D.H., Saeed, M., "Analysis of carboxcylic and related acids in the environment by capillary electrophoretic techniques", Journal of Chromatography A, 827:1, 1-12,1998
(12)Poels, I., Schasfoort, R.B.M., Picioreanu, S., "An ISFET-baset anion sensor for the potentiometric detection of organic acids in liquid chromatography", Sensors and Actuators B: Chemical, 67:3, 294-299,2000
(13)Zhang, Y., Wei, W., Yao, S.Z., "Determination of divalent carboxcylic acids in traditional Chinese herbal and patent medicines using HPLC with double cell quartz crystal detector", Journal of Pharmaceutical and Biomedical Analysis, 23:2-3, 387-393, 2000
(14)Almuaibed, A. M.,"Microscale on-line production and determination of malic acid using flow injection analysis, immobilized fumrase and malate de hydrogenase with chemiluminescence detection", Analytica Chimica Acta, 428:1, 1-6, 2001