The evaluation of Accu-Chek Inform II® and Hexokinase Method in Emergency Departments for Glucose Measurement

Amaç: Acil servisler ve yoğun bakım ünitlerinde kan şekeri düzeyinin, hızlı ve doğru tayinin, hastaların tanısı, tedavisi ve takibinde kritik bir öneme sahip olması nedeniyle hasta başı test sistemi (POC) glukometrelerin kullanımı, giderek önem kazanmaktadır. Bizim bu çalışmada amacımız, acil servis hastalarında hastane tipi glukometre sonuçları ile referans metod heksokinaz ile çalışılan kan şekeri sonuçları arasındaki uyumluluğu değerlendirmektir. Materyal ve metod: 104 hastanın glukoz düzeyi heksokinaz yöntemi ile Abbott Arcitecht C16000 cihazı ve Accucheck Inform II® ile ölçüldü. Sistemler arasındaki uyumluluğa Bland- Altman ve Passing-Bablok regresyon analizi ve Error Grid analizi ile bakıldı. Bulgular: 104 hastann yaş ortalaması 43.6 ± 15.7 yıldı. Accucheck Inform II cihazında ve referans yöntem ile elde edilen ortalama glukoz seviyeleri sırasıyla 180.67mg/dL ± 12.57 ve 194.26mg/dL ± 14.55 idi. Gruplar arasında istatsitiksel anlamlı fark bulunmadı (P>0.05). Her iki sistemin korelasyonunda R2 değeri 0.967 (%95 CI, 0.952-0,977) olarak izlenirken regresyon denklemi Y=9,46+0.88213X olarak hesaplandı. Error grid analizinde hastaların %89'u A, % 9'u B, %2 'si C bölgesi'nde izlenmiştir. Sonuç: Referans yöntem ile karşılaştırıldığında hastane tipi glukpmetre sistemi sonuçlarının hastaların % 97'sinde uyumlu ve klinik sonuçlarına etkilerinin güvenli olduğunu bulunmuştur.

Acil Servislerde Kan Glukoz Sonuçlarının Glukometre ve Referans Heksokinaz Yöntemi ile Karşılaştırılması

Objective: Glycemic control has a critical role especially in surgical and medical intensive care units and emergency departments (ED), so point-of- care (POC) glucose monitoring has become increasingly important. The aim of our study was to compare the glucose levels of emergency patients, measured with the Accu-Chek Inform II® and hexokinase reference method. Methods: One-hundred-four patients' glucose levels were studied with hexokinase method in Abbott Architect C16000 device and Accu-Chek Inform II®. The results were analyzed with Error Grid method. Agreement between the systems was assessed using Bland- Altman and Passing-Bablok regression analysis. Results: Among 104 patients, the mean participant age was 43.6 ± 15.7 years. Mean glucose levels measured with Accu-Chek Inform II® glucose and reference method were 180.67mg/dL ± 12.57 and 194.26mg/dL ± 14.55, respectively. There was no statistically significant difference between the groups (P>0.05). These two systems' R2 value was found to be 0.967 (95% CI, 0.952-0,977). The regression equation was Y=9,46+0.88213X. The error grid analysis showed that 98% of the results fell in the Zone A (89%) and Zone B (9%). Two percent of the results was located in Zone C. Conclusion: The performance of the Accu-Chek Inform II® System was found to be reliable according to currently used reference methods in central laboratories.

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