Ümit TÜRSEN, Tamer İrfan KAYA, Pınar İNAN, Güliz İKİZOĞLU

Sistemik lupus eritematozuslu bir olguda vulvar invaziv skuamöz hücreli karsinom

Sistemik lupus eritematosus maligniteyi de içeren geniş spektrumda bulgu ve çeşitli organ tutulumları ile seyreden bir kronik otoimmün hastalıktır. Bugüne kadar otoimmün hastalıklarda artmış malignite bildiren yayınlar olmakla beraber normal popülâsyonla aralarında anlamlı bir fark olmadığım bildiren yayınlar da vardır. Burada 52 yaşında, 20 yıllık SLE öyküsü bulunan bir bayan hastada vulvar invaziv skuamöz hücreli karsinom birlikteliği gösteren bir vaka bildirdik. Önceden sadece 4 SLE olgusunun vulvar veya vajinal kanserle ilişkisi literatürde bildirilmiştir. Bu olgu literatürde daha önce bildirilmiş olan 25 yaşındaki SLE hastasından sonra ikinci ayrıntılı örnek olması nedeni ile önem teşkil etmektedir.

A case of systemic lupus erythematosus associated with vulvar invasive squamous cell carcinoma

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease whose long-term sequelae may include many types of comorbidity, including neoplasia. The association between SLE and malignancy has as yet not been established and it is still debatable whether SLE patients have an increased incidence of cancer overall compared to the general population. However, several studies have demonstrated a possible relationship between SLE and several neoplasia. We report a case of invasive vulvar squamous cell carcinoma occurring in a 52-year-old SLE patient. Only four cases of vaginal/vulvar cancer associated with SLE have previously been mentioned in the literature. To the best of our knowledge, this is the second detailed case report in the literature of vulvar invasive squamous cell carcinoma in a SLE patient.

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