Atilla ÇAYIR, Sadi VİDİNLİSAN, Tuncer GÜRLER, Reha CENGİZLER, Eda ÖZAYDIN, Gülsen KÖSE

Lamotrigine-inducet hypersensitivity syndrome: Case report

Antikonvülzan hipersensitivite sendromu (AHS ); aromatik antiepileptik ilaçlarla olduğu bildirilen, hayatı tehdit eden, idiosenkratik, doza bağımlı olmayan bir ilaç reaksiyonudur. Ateş, döküntü, lenfadenopati. karaciğer ve akciğer tutulumuyla hipersensitivite sendromu tanısı alan 11 yaşında kız hastayı sunuyoruz. Belirti ve bulguların zamanında fark edilmesi, ilacın kesilmesi, destek tedaviler ve yakın izlem AHS'un tedavisinde çok önemli olmakla beraber hastamızda olduğu gibi multiorgan tutulumu olan ciddi vakalarda sistemik kortikosteroidlerin ve intravenöz immun-globulinin kullanılması iyi bir tedavi seçeneği olarak görülmektedir. Antiepileptik tedavi başlandıktan sonra yakın laboratuar ve klinik izlemin ve ilaçların yan etkileri hakkında ailelerin bilgilendirilmesinin önemini bir kez daha vurgulamak için olgumuzu sunuyoruz.

Lamotrijinle indüklenen hipersensitivite sendromu: Olgu sunumu

Anticonvulsant hypersensitivity syndrome (AHS) is a life-threatening, idiosyncratic, non-dose related adverse reaction reported to occur with aromatic anticpileptic drugs. We present an 11-year-old girl diagnosed with hypersensitivity syndrome with a fever, rash, lymphadenopathy, and hepatic and pulmonary involvement. Although timely recognition of the signs and symptoms, discontinuation of the drug, supportive care, and close observation are crucial in the management of AHS, the use of systemic corticosteroids and intravenous immunoglobulin seems to be a good option for severe cases with multiorgan involvement as in our patient. We present our case to emphasize once more the importance of close laboratory monitoring and clinical follow-up after starting antiepileptic drugs and also informing the families about the adverse effects of drugs.

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