Mehmet Akif TÜRKOĞLU, Mehmet İBİŞ, Hasan Şenol COŞKUN, Veli VURAL, Hakan BOZCUK, Halil ERBİŞ

"Liver-First Approach" as an Unusual Treatment Modality for Rectal Cancer with Synchronus Liver Metastasis: Report of a Case

Genel sağkalım, senkron karaciğer metastazı olan kolorektal kanserli hastalarda sıklıkla metastazların sayısı ve ebatına göre belirlenir. Geleneksel olarak böyle hastalarda standart tedavi, öncelikle primer kolorektal tümör rezeksiyonu daha sonra mümkünse, kemoterapi sonrası karaciğer metastazlarının rezeksiyonudur. Bu yazıda, reverse bir yaklaşım uygulanan senkron karaciğer metastazlı rektal kanser olgusunu sunmaktayız

Eşzamanlı Karaciğer Metastazlı Rektum Kanserinde Nadir Bir Tedavi Yöntemi Olarak "Önce Karaciğer Yaklaşımı": Olgu Sunumu

Overall survival is usually determined by the number and the magnitude of liver metastases in colorectal cancer patients with synchronous hepatic metastases. Traditionally, thestandard treatment of such patients are, firstly colorectal resection of the primary tumor, then if possible, the resection of liver metastases after chemotherapy. Here, we present a case of rectal cancer with synchronus liver metastasis which underwent reverse approach

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Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ, Thun MJ, Cancer statistics, 2005. CA Cancer J Clin. 2005;55:10-30.
Vassiliou I, Arkadopoulos N, Theodosopoulos T et al, Surgical approaches of resectable synchronous colorectal liver metastases: timing considerations. World J Gastroenterol. 2007 7;13:1431-4.
Slesser AA, Bhangu A, Brown G, Mudan S, Tekkis PP. The management of rectal cancer with synchronous liver metastases: a modern surgical dilemma. Tech Coloproctol. 2013; 17: 1-12.
Adam R, Pascal G, Castaing D, Azoulay D, Delvart V, Paule B, Levi F, Bismuth H. Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases? Ann Surg. 2004;240: 1052-61.
Yoshidome H, Kimura F, Shimizu H, Ohtsuka M, Kato A, Yoshitomi H, Furukawa K, Mitsuhashi N, Takeuchi D, Iida A, Miyazaki M. Interval period tumor progression: does delayed hepatectomy detect occult metastases in synchronous colorectal liver metastases? J Gastrointest Surg. 2008;12:1391-8.
Viganò L, Karoui M, Ferrero A, Tayar C, Cherqui D, Capussotti L. Locally advanced mid/low rectal cancer with synchronous liver metastases. World J Surg. 2011;35:2788-95.
Verhoef C, van der Pool AE, Nuyttens JJ, Planting AS, Eggermont AM, de Wilt JH. The "liver-first approach" for patients with locally advanced rectal cancer and synchronous liver metastases. Dis Colon Rectum. 2009;52:23-30.
Mentha G, Roth AD, Terraz S, Giostra E, Gervaz P, Andres A, Morel P, Rubbia- Brandt L, Majno PE. 'Liver first' approach in the treatment of colorectal cancer with synchronous liver metastases. Dig Surg. 2008;25:430-5.
Reddy SK, Zorzi D, Lum YW, Barbas AS, Pawlik TM, Ribero D, Abdalla EK, Choti MA, Morse Kemp Timing of multimodality therapy for resectable synchronous colorectal liver metastases: a retrospective multi-institutional analysis. Ann Surg Oncol. 2009;16:1809-19. MA, White RR, Clary BM.
de Haas RJ, Adam R, Wicherts DA, Azoulay D, Bismuth H, Vibert E, Salloum C, Perdigao F, Benkabbou A, Castaing D. Comparison of simultaneous or delayed liver surgery for limited synchronous colorectal metastases. Br J Surg. 2010;97:1279- 89.
Tsoulfas G, Pramateftakis MG. Management of rectal cancer and liver metastatic disease: which comes first? Int J Surg Oncol. 2012; doi: 10.1155/2012/196908.