İlknur MUTLU, Gamze Sinem ÇAĞLAR, Müşerref Banu YILMAZ, Mine KİSELİ, Aslı Yarcı GÜRSOY, Emre GÖKSAN PABUÇCU

İleri Yaşta Dehidroepiandrosteron ile Spontan Gebelik: Üç Olgu Sunumu ve Literatür

Son yıllarda dehidroepiandrosteronun düşük over rezervli hasta grubunda infertilite tedavisine yanıtı arttırdığı saptanmıştır. Bu olgu serisinde, 35 yaşından büyük ve kötü over rezervi, yüksek 3. gün FSH'sı ve düşük antral folikül sayısı ile kanıtlanmış üç hastada kısa süreli dehidroepiandrosteron kullanımı ile spontan gelişen ve sağlıklı biçimde terme ulaşan gebelik olguları ve geçirilmektedir. Dehidroepiandrosteron ile yapılan çok geniş randomize çalışmalar bulunmasa da literatürdeki olgu sunumları ve burada sunulan vakalar, bu androjenin düşük over rezervli hastalarda spontan gebelik şansını arttırdığını kanıtlamaktadır. Gebeliklerin ileri anne yaşına rağmen sağlıklı canlı doğum ile sonuçlanmaları da oosit kalitesini iyileştirdiği fikrini desteklemektedir

Spontaneous Pregnancy with Dehydroepiandrosterone in Advanced Age Patients: Three Case Reports and Literature Review

It has been reported recently that dehydroepiandrosterone (DHEA) supplementation in older patients with low ovarian reserve increases the response to infertility treatment. Three women of age >35 years with low ovarian reserve parameters including high FSH, low AFC have been treated with DHEA for various time intervals are reported here. They conceived spontaneously after a few months of treatment which resulted in healthy newborns. Although there are not many randomized controlled trials about the value of DHEA treatment in infertile patient population, previous case reports support that DHEA increases spontaneous pregnancy rates. Considering healthy livebirths of the relatively older age of the mentioned cases, DHEA might be improving also oocyte quality as an additional impact

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