Kantaron Ekstresinin Gentamisinin Neden Olduğu Ototoksisite Üzerinde Koruyucu Etkisi

Amaç: Hypericum perforatum tarla, yol ve orman kıyılarında, tepelerde veçayırlarda Temmuz'dan Eylül'e kadar çiçeklenen ve ülkemizde, sarı kantaron,kanotu, kılıçotu, mayasilotu ve yaraotu gibi adlara sahip ve bazı hastalıklarakarşı yöresel insanlar tarafından kullanılan bitkidir ve yapılan çalışmalardaanti inflamatuar ve antioksidant etkinliği gösterilmiştir. Bu nedenle kantaronbitkisinin gentamisin ile oluşturulan ototoksisite üzerinde koruyucu etkinliğiolup olmayacağını planladık.Yöntem: Bu amaçla ferelere 9 gün 100 mg/kg gentamisin ve gentamisinlebirlikte 70 mg/kg kantaron ekstresi verildi. 9. ve 10. günlerde gentamisinin vekantaron ekstraktının farelerin motor koordinasyonunu üzerine etkisinideğerlendirmek için rotarod testi uygulandı.Bulgular: Gentamisin uygulaması farelerin düşüş süresini azalttı. Gentamisinile birikte kantaron ekstaktı verilmesi bu süreyi uzattı.Sonuç: Çalışmamız gentamisinin neden olduğu ototoksisiteyi önlemedeyararlı olacağını göstermiştir.

Protective Effect Of Hypericum Perforatum Extract On Gentamicin Induced Ototoxicity

Objective: Hypericum perforatum, which have various names locally such as "sarı kantaron, kanotu, kilicotu, mayasilotu, yaraotu", is a plant which blooms between july and september at farms, borders of roads and woods, top of hills and grasslands, whose anti-inflammatory and antioxidant effects are shown in various studies. Due to this reason, we planned a study to examine the protective effects of Hypericum perforatum on ototoxicity caused by gentamicin. Methods: For this purpose, 100 mg/kg gentamicin and 70 mg/kg Hypericum perforatum extract are administered to mice for 9 days. On the 9th and 10th days rotarod performance was assessed to evaluate the Gentamicin and Hypericum Perforatum extract on motor coordination of mice. Results: Gentamicine treatment decreased fall latency of mice and Gentamicine together Hypericum Perforatum extract treatment increased fall latency of mice. Conclusion: Our study showed that Hypericum Perforatum extract will be usefull to prevent gentamicin induced ototoxicity.

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