Effects of an acute exercise up to anaerobic threshold on serum anabolic and catabolic factors in trained and sedentary young males

Amaç: Bu çalışmanın amacı antrene ve sedanter genç erkeklerde anaerobik eşiğe kadar yapılan aerobik egzersizin etkilerini araştırmaktır. Yöntemler: Katılımcıların kan örneklerinde İnterlökin-6 (IL-6), oksidanlar ve kortizol gibi katabolik faktörler ile testosterone, büyüme hormonu ve insülin benzeri büyüme faktörü-1 gibi anabolik faktörlerin düzeyleri ölçülmüştür. Bulgular: Anaerobik eşiğe kadar yapılan koşu egzersizinin her iki grupta da oksidanları arttırdığı fakat IL-6 düzeylerini etkilemediği görülmüştür. Ayrıca oksidanlar antrene grupta 24 saat içinde bazal düzeylere inmiştir. Kortizol miktarı egzersizden 24 saat sonra her iki grupta da bazal düzeyin dahi altına düşmüştür. Anabolik hormonlar ise, özellikle antrene grupta olmak üzere her iki grupta da egzersizden sonra artış göstermiştir. Sonuç: Antrene gençler egzersize, aynı yaş grubundaki sedanterlere göre daha hızlı anabolik ve katabolik adaptasyon göstermektedirler.

Antrene ve sedanter genç erkeklerde anaerobik eşiğe kadar yapılan akut egzersizin serum anabolik ve katabolik faktörlerine etkileri

Objective: The aim of the present study was to evaluate the effects of aerobic running exercise up to anaerobic threshold in trained (T) and sedentary (S) young males. Methods: The catabolic factors such as interleukin-6 (IL-6), oxidants and cortisol and the anabolic factors such as testosterone, growth hormone (GH) and insulin-like growth factor (IGF-I) were evaluated in blood serum of subjects. Results: It was found that running up to anaerobic threshold led to a significant increase in oxidants but not IL-6 in both groups. Indeed, oxidants returned to basal levels in 24 h in the T group. Cortisol decreased even below the basal levels 24 h after exercise in both groups. Anabolic hormones increased in both groups especially in the trained subjects after exercise. Conclusion Trained young people showed faster anabolic and catabolic adaptation to aerobic exercise comparing to age-matched sedentaries.

___

  • 1.Ahtiainen JP, Pakarinen A, Kraemer WJ, Hakkinen K. Acute Hormonal Responses to Heavy Resistance Exercise in Strength Athletes versus Nonathletes. Can J Apply Physiol 2004; 29: 527- 43.
  • 2.Narin SO, Pinar L, Erbas D, Ozturk V, Idiman F. The effects of exercise and exercise-releated changes in blood nitric oxide level on migraine headache. Clin Rehab 2003; 17: 624-30.
  • 3.Tanaka K, Matsaura Y, Kumagai S, Matsuzuka A, Hirakoba K, Asano K. Relationships of anaerobic threshold and onset of blood lactate accumulaton with endurance performance. Eur J Apply Physiol Occup Physiol 1983; 52: 51-6.
  • 4.Meckel Y, Eliahim A, Seraev M, Zaldivar F, Cooper DM, Sagiv M, et al. The effect of a brief sprint interval exercise on growth factors and inflammatory mediators. Strength Cond Res 2009; 23: 225-30.
  • 5.Pedersen BK, Ostrowski K, Rohde T, Bruunsgaard H. The cytokine response to strenuous exercise. Can J Physiol Pharmacol. 1998;76:505-11.
  • 6.Bodell PW, Kodesh E, Haddad F, Zaldivar FP, Cooper DM, Adams GR. (2009) Skeletal muscle growth in young rats is inhibited by chronic exposure to IL-6 but preserved by concurrent voluntary endurance exercise. J Appl Physiol; 106: 443-53.
  • 7.Niess AM, Sommer M, Schneider M, Angres C, Tschositsch, Golly IC, et al. Physical exercise-induced ekspression of inducible nitric oxide synthase and heme oxygenase-1 in human leukocytes: effects of RRR-alpha-tocopherol supplementation. Antioxid Redox Signal 2000; 2: 113-26.
  • 8.Pedersen BK, Steensberg A, Fischer C, Keller C, Keller P, Plomgaard P, et al. The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor? Proceed Nutrition Society 2004; 63: 263-7.
  • 9.Steensberg A, Fischer CP, Keller C, Moller K, Pedersen BK. IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab 2003; 285: 433-7.
  • 10.Hug M, Mullis PE, Vogt M, Ventura N, Hoppeler H. Training modalities over-reaching and over-training in athletes, including a study of the role of hormones. Best Pract Res Clin Endocrinol Metab. 2003; 17: 191-209.
  • 11.Frystyk J. Exercise and growth hormone-insulin-like growth factor axis. Med Sci Sports Exerc 2010; 42: 58-66.
  • 12.Vellosa CP. Regulation of muscular Mass by Growth Hormone and IGF-1. Br J Pharmacol 2008; 154: 557-68.
  • 13.Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, et al. Physical Activity and Public Health: Updated Recommendation for Adults from American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc 2007; 39: 1423- 34.
  • 14.Arai MH, Duarte AJS, Natale VM. The effects of long-term endurance training on the immune and endocrine systems of elderly men: the role of cytokines and anabolic hormones. Immun Ageing 2006; 3: 9.
  • 15.Léger LA, Mercier D, Gadoury C, Lambert J. The multistage 20 metre shuttle run test for aerobic fitness. J Sports Sci 1988; 6: 93– 101.
  • 16.Wasserman K, Beaver WL, Whipp B. Mechanism and Patterns of Blood Lactate Increase During Exercise in Men. Med Sci Sports Exerc 1986; 18: 344-52.
  • 17.Kurtel H, Granger DN, Tso P, Grisham MB. Vulnerability of intestinal interstitial fluid to oxidant stress. Am J Physiol Gastrointest Liver Physiol 1992; 263: 573-8.
  • 18.Woods JA, Vieira VJ, Keylock KT. Exercise, inflammation and innate immunity. Immunol Allergy Clin N Am 2009; 29: 381-93.
  • 19.Fujita J, Tsujinaka T, Ebisui C, Monden M. Role of interleukin-6 in skeletal muscle protein breakdown and cathepsin activity in vivo. Eur Surg Res 1996; 28: 361-6.
  • 20.LeMaitre JP, Harris S, Fox KA, Denvir M. Change in circulating cytokines after 2 forms of exercise training in chronic stable heart failure. Am Heart J 2004; 147:100-5.
  • 21.Nicklas BJ, Ambrosius W, Messier SP, Miller GD, Penninx BW, Loeser RF, et al. Diet-induced weight loss, exercise, and chronic inflammation in older obese adults: a randomized controlled clinical trial. Am J Clin Nutr 2004; 79: 544-51.
  • 22.Department of Health and Human Services (DHHS). Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion. Physical Activity and Health: A Report of Surgeon General. Atlanta GA: DHHS; 1996.
  • 23.Fischer CP. Interleukin-6 in acute exercise and training: what is the biological relevance? Exerc. Immunol. Rev. 2006; 12: 6-33.
  • 24.Markovitch D, Tyrrell RM, Thompson D. Acute moderate-intensity exercise in middle-aged men has neither an anti- nor proinflammatory effect. J Appl Physiol 2008; 105:260-5.
  • 25.Davies KJA, Quintanilha TA, Brooks GA, Packer L. Free radical and tissue demage produced by exercise. Biochem Biophys Res Comm 1982; 107: 1198-205.
  • 26.Ji LL. Oxidative stres during exercise: Implication of antioxidant nutriens. Free Radical Biol Med 1995; 18(6): 1079-86.
  • 27.Häkkinen K, Pakarinen A. Acute hormonal responses to two different fatiguing heavy-resistance protocols in male athletes.J Appl Physiol. 1993;74):882-7.
  • 28.Cappola AR, Xue QL, Ferruci L, Guralnik JM, Volpato S, Fried LP. Insulin-like growth factor-I and interleukin-6 contribute synergistically to diability and mortality in older women. J Clin Endocrinol Metab. 2003; 88: 2019-25.
  • 29.Schwarz AJ, Brasel JA, Hintz RL, Mohan S, Cooper DM. Acute Effect of Brief Low-and High-Intensity Exercise on Circulating Insulin-like Growth Factor (IGF) I, II and IGF-Binding Protein 3 and its Proteolysis in Young Healthy Men. J Clin Endocrinol Metab 1996 Oct; 81: 3492-7.
Gazi Medical Journal-Cover
  • Yayın Aralığı: Yılda 4 Sayı
  • Yayıncı: Gazi Üniversitesi Tıp Fakültesi
Sayıdaki Diğer Makaleler

Bir çocuk olguda ebv enfeksiyonuna bağlı gelişen akut kolesistit

Gülsüm İclal BAYHAN, Çiğdem ÜNER, Muhammet Furkan BAKKAL, Gönül TANIR

Onbir yaşına kadar gözden kaçan siyanoz

Ayhan PEKTAŞ, Serdar KULA, Abdullah İrfan TAŞTEPE2, Fatma Sedef TUNAOĞLU, Ayşe Deniz OĞUZ, Semiha TERLEMEZ

Incidental situs inversus totalis detected by ga-68 dota-tate pet/ct

Emre DEMİRCİ, Metin HALAC, Sait SAGER, Sabire AKSOY YILMAZ, Sertac ASA

Laurance-moon-bardet-biedl sendromlu bir hastanın dental tedavisinde monitörize anestezi bakımı

Sıla ŞAHİN, Ayşe Hande ARPACI

Evaluation of clinical features of 238 cases with febrile convulsion

Yusuf AYDIN, Ebru YILMAZ, Deniz YILMAZ, Mesut KOÇAK, Ali Osman KÖKSAL, Osman ÖZDEMİR, Aslıhan YILMAZ ARASLI

Comparison of erythrocyte sedimentation rate results of test-1 and automatic westergren device with reference westergren method

Kadir Okhan AKIN, Gülcan GÜNTAŞ, Ayşegül KAYMAK ÖZTÜRK, Nedim AKKAYA, Çiğdem SÖNMEZ

Mother approaches to children with fever

Fatma Tuba YILDIRIM, Burcu ÖZKAN, Özgen HÜR, Mesut KOÇAK, Şanlıay ŞAHİN, Ali Osman KÖKSAL, Mehtap ACAR, Şerife YILMAZ, Osman ÖZDEMİR, Aslıhan YILMAZ ARASLI

Clinical speciality of 500 headache patients: Documentations of headache center

Levent E. İNAN, Serap ÜÇLER, Hilal TOGAN, Özlem COŞKUN

Effects of an acute exercise up to anaerobic threshold on serum anabolic and catabolic factors in trained and sedentary young males

Çiğdem ÖZER, Şehri ELBEG, Gamze ERİKOGLU, Lamia PINAR, Zeynep TUNA, Latife Arzu ARAL, Ayşegül ATAK, Nevin GÜZEL ATALAY

A metastatic parachordoma case

Ajlan ATASOY, Sener CİHAN, Birsen Songul CİHAN, Tugba Fahriye KOS, Nalan BABACAN AKGUL