Fatih AKIN, Harun PERU, Ahmet ÖZEL, Ahmet Midhat ELMACI, Diclehan ORHAN

Early onset of IgA nephropathy presenting with nephrotic syndrome

5 yasında erkek hasta hastanemize vucudunda sislik nedeniyle basvurdu. İdrar analizinde mikroskopik hematüri ve nefrotik düzeyde proteinüri saptandı. Kan basıncı normal sınırlardaydı. Kompleman 3 ve 4 düzeyleri normal, ANA negatifti. Hastaya 4 hafta süreyle prednizolon tedavisiverilmesine rağmen proteinürisi sebat ettiği için perkütan böbrek biyopsisi yapıldı. Biyopsi IgA nefropatisi ile uyumluydu. Tedaviye siklofosfamid eklendi. Proteinuri 12 haftalık siklofosfamid tedavisinden sonra düzeldi. Bu IgA nefropati olgusu erken yasta nefrotik sendrom kliniği ile ortaya çıkması sebebiyle rapor edilmistir.

Erken yaşta nefrotik sendrom kliniği ile ortaya çıkan IgA nefropatisi

A 5-year-old boy was admitted to our hospital with the complaint of swelling of his whole body. Urine analysis revealed nephrotic range proteinuria and microscopic hematuria. He was normotensive. Complement C3 and C4 levels were normal. Antinuclear antibodies (ANA) were negative. A percutaneous renal biopsy was performed because of the persistent proteinuria despite a full course of 4 weeks of steroid treatment. The renal biopsy was consistent with IgA nephropathy. Then cyclophosphamide was added to the treatment. Proteinuria disappeared after 12 weeks of cyclophosphamide treatment. This case of IgA nephropathy is reported because of the early age of onset and because of presenting with nephrotic syndrome.

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