Birinci trimester serum ürik asit düzeyi ölçümü ile gebelikteki glukoz intoleransı tahmin edilebilir mi?

Amaç: Bu çalışmada 1. Trimester serum ürik asit düzeyi ölçümünün gebelikteglukoz intoleransını tahmin etmedeki rolünü incelemeyi amaçladıkMateryal ve metod: Fatih Üniversitesi Tıp Fakültesi Kadın Hastalıkları veDoğum Polikliniğine rutin antenatal takip için başvuran 1. trimesterdekihastalar çalışmaya dahil edildi. Tüm hastaların serum ürik asit düzeyleriölçüldü. Gebeliğin 24-28. haftaları arasında hastalara önce 50 gr glukozyükleme testi (GCT) yapıldı ve 1.saat kan şekeri ≥140 mg/dl olan hastalara100 gr glukoz tolerans testi uygulandı. 50 gr GCT sonucu ≥140 mg/dl olanfakat 100 gr glukoz tolerans testi normal olan hastalar glukoz intoleransıolarak tanımlandı. Serum ürik asit düzeyi ile GCT düzeyleri arasındaki ilişkilineer regresyon analizi ile hesaplandı.Bulgular: Çalışmaya toplam 62 hasta dahil edildi. Hastaların ortalama yaşı29,3±3,6 yıl, gebelik haftası 7.1 (2) hafta, ürik asit 3,1±0,7 mg/dl ve GCT121,0±25,3 mg/dl idi. Hastalar GCT 130 mg/dl değeri sınır kabul edilerek 2gruba ayrıldı ve ürik asit seviyeleri kıyaslandı. GCT değerleri 130 mg/dlinaltında olanlarda ortalama ürik asit düzeyleri 3,0±0,7 mg/dl iken, 130 mg/dlve üzerinde olanlarda 3,3±0,9 mg/dl olarak saptandı ancak aradaki farkistatistiksel olarak anlamlı değildi (p=0,277). Korelasyon analizinde ürik asitseviyeleri ile GCT değerleri arasında minimal korelasyon saptandı ancak ilişkiistatistiksel olarak anlamlı değildi (R=0,147, p=0,255).Sonuç: Hasta populasyonumuzda, birinci trimester serum ürik asit düzeyleriile GCT değerleri arasında anlamlı korelasyon saptanmamıştır.

Can glucose ıntolerance be predicted by first trimester serum uric acid measurement?

Aim: We aimed to evaluate the role of first trimester serum uric acide level to predict glucose intolerance in pregnancy. Method: Patients who admitted to Fatih University Faculty of Medicine for routine antenatal follow-up at first trimester were included in the study. Serum uric acid levels were measured at first trimester. Glucose challenge test-50g (GCT) was performed between 24-28 gestational weeks. Glucose tolerance test-100g was performed if one hour GCT value was ≥140 mg/dl. Women who had abnormal GCT but normal glucose tolerance test were defined as glucose intolerance. Corelation between serum uric acid level and GCT was calculated by lineer regression analysis. Results: Sixty-two patients were included in the study. The mean age, gestational age, serum uric acid level and GCT values were 29.3±3.6 years, 7.1 (2) weeks, 3.1±0.7 mg/dl and 121.0±25.3 mg/dl, respectively. The mean uric acid level of patients with

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