Approach to a Patient with Multiple Lung and Brain Carcinomas
Şiddetli öksürük ve nefes darlığı yakınması ile çoklu akciğer ve beyin metastazları olan 55 yaşındaki erkek hastayı sunduk. Öyküsünde herhangi bir sistemik hastalığı yoktu. Biyokimyasal tetkikleri normaldi. Akciğerin sol üst lobunda asemptomatik primer büyük hücreli karsinoma; sağ üst lobda ise az differansiye squomoz hücreli karsinom bilgisayarlı tomografi ve bronkoskopik biyopsi ile tespit edildi. Hastaya primer akciğer karsinomu için radyoterapi ve kemoterapi uygulandı. Magnetik Rezonans görüntüleme ile beyin de çoklu metastazlar görüntülendi. Sol temporal lobda 3 cm, sağ temporal lobda 3,5 cm metastatik tümör görüldü. Diğer bölglerde metastaza rastlanılmadı. Tümörlere yönelik; öncelikle sağ frontotemporal sonrada sol temporal yaklaşım ile total mikrorocerrahi rezeksiyon uygulandı.Hasta şifa ile taburcu edildi.
Çoklu Akciğer ve Beyin Metastazları olan Hastaya Yaklaşım
We report a case of lung cancer with multiple metastases to the brain. A 55year-old man suffered onset severe cough and dyspnea. He had no history of any systemic disease. Standard blood work-up was normal. Computed tomographic and bronchoscopic biopsy identified an asymptomatic primary pulmonary large cell neuroendocrine carcinoma in the left upper lobe of the lungs and less differentiated squamous cell carcinoma right upper lobe of the lungs. He also received chemotherapy and radiation therapy to treat the primary lung cancer. Magnetic resonance imaging of the brain revealed multiple intracranial tumors, including 3 cm metastatic mass in left temporal lobe and 3,5 cm metastatic mass in right frontal lobe. There were no metastatic findings in any other organs. First of all, the patient underwent a right frontotemporal approach with total microsurgical resection and after time underwent a left temporal approach with total microsurgical resection . He made good recovery and discharged.
___
- Mintz BJ, Tuhrim S, Alexander S, et al. Intracranial metastases in the initial staging of bronchogenic carcinoma. Chest 1984; 86: 850-3.
- Taimur S, Edelman MJ. Treatment options for brain metastases in patients with non-small-cell lung cancer. Curr Oncol Rep 2003;5: 342-6.
- Lamm AF, Elaimy AL, Mackay AR, Fairbanks RK, Demakas JJ, Cooke BS, Lee CM, Taylor BS, Lamoreaux WT. Long-Term Survival of a Patient with Brainstem and Recurrent Brain Metastasis from Stage IV Nonsmall Cell Lung Cancer Treated with Multiple Gamma Knife Radiosurgeries and Craniotomies: A Case Report and Review of the Literature. Case Rep Oncol Med. 2012; 2012: 621-41.
- Malacarne P, Santini A, Maestri A. Response of brain metastases from lung cancer to systemic chemotherapy with carboplatin and etoposide. Oncology 1996;53: 210-3.
- Bruner, J.M., Tien, R.D.: Secondary tumors. In: Bigner DD, McLendon RE, Bruner JM (eds). Russell and Rubinstein's Pathology of Tumors of the Nervous System, 6th edn, Vol. 2. London: Arnold, 1998; 419-50.
- Ryan G, Ball D, Bishop J, et al. (1994) A phase II study of combined chemotherapy and radiation for brain metastases from nonsmall- cell lung carcinoma of the lung. Lung Cancer 11 (Suppl1):176
- Quantin X, Khial F, Reme-Saumon M, et al. Concomitant brain radiotherapy and vinorelbine-ifosfamide-cisplatin chemotherapy in brain metastases of non-small cell lung cancer. Lung Cancer 1999; 26: 35-9.
- Harita S, Mizuta A, Kuyama S, Kikuchi T.Long-term survival following concurrent chemoradiotherapy in patients with non-small-cell lung cancer with concomitant brain metastases only. Int J Clin Oncol. 2005; 10:63-8.